Biology, Journal Year: 2025, Volume and Issue: 14(3), P. 314 - 314
Published: March 20, 2025
Spinal cord injury (SCI) is a life-altering condition that leads to severe neurological deficits and significantly impacts patients’ quality of life. Despite advancements in medical care, current treatment options remain largely palliative, with limited ability promote meaningful functional recovery. Induced pluripotent stem cells (iPSCs) have emerged as promising avenue for regenerative medicine, offering patient-specific, cell-based therapeutic potential SCI repair. This review provides comprehensive overview recent iPSC-based approaches SCI, detailing the strategies used generate neural cell types, including progenitor cells, oligodendrocytes, astrocytes, microglia, their roles promoting neuroprotection regeneration. Additionally, we examine key preclinical clinical studies, highlighting recovery assessments discussing both standardized debated evaluation metrics. Furthermore, address critical challenges related safety, tumorigenicity, immune response, survival, integration, overcoming inhibitory microenvironment injured spinal cord. We also explore emerging biomaterial scaffolds, gene editing, rehabilitation may enhance applicability therapies. By addressing these refining translational strategies, interventions hold significant revolutionize improve outcomes affected individuals.
Language: Английский