European Consensus on Malabsorption—UEG & SIGE, LGA, SPG, SRGH, CGS, ESPCG, EAGEN, ESPEN, and ESPGHAN. Part 1: Definitions, Clinical Phenotypes, and Diagnostic Testing for Malabsorption DOI Creative Commons
Marco Vincenzo Lenti, Heinz F. Hammer, Ilja Tachecí

et al.

United European Gastroenterology Journal, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

Malabsorption is a complex and multifaceted condition characterised by the defective passage of nutrients into blood lymphatic streams. Several congenital or acquired disorders may cause either selective global malabsorption in both children adults, such as cystic fibrosis, exocrine pancreatic insufficiency (EPI), coeliac disease (CD) other enteropathies, lactase deficiency, small intestinal bacterial overgrowth (SIBO), autoimmune atrophic gastritis, Crohn's disease, gastric bowel resections. Early recognition key for tailoring proper diagnostic work-up identifying malabsorption. A patient's medical pharmacological history essential risk factors. examinations endoscopy with biopsies, non-invasive functional tests radiological imaging are useful diagnosing Because its high prevalence, CD should always be looked cases no obvious explanations high-risk individuals. Nutritional support management patients malabsorption; different options available, including oral supplements, enteral parenteral nutrition. In short syndrome, teduglutide proved effective reducing need nutrition, thus improving quality life these patients. Primary care physicians play central role early detection involved multidisciplinary teams overall this European consensus, involving ten scientific societies several experts, we have dissected all issues around malabsorption, definitions testing (Part 1), categories special populations, nutritional assessment management, primary perspective 2).

Language: Английский

Chronic Gastrointestinal Disorders and miRNA-Associated Disease: An Up-to-Date DOI Open Access
Alessandro Giammona, Bruno G. Galuzzi, Elena Imperia

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(1), P. 413 - 413

Published: Jan. 6, 2025

Chronic gastrointestinal disorders such as inflammatory bowel diseases (IBDs) and irritable syndrome (IBS) impose significant health burdens globally. IBDs, encompassing Crohn’s disease ulcerative colitis, are multifactorial characterized by chronic inflammation of the tract. On other hand, IBS is one principal tract functional abdominal pain altered habits. Although precise etiopathogenesis these remains unclear, mounting evidence suggests that non-coding RNA molecules play crucial roles in regulating gene expression associated with inflammation, apoptosis, oxidative stress, tissue permeability, thus influencing progression. miRNAs have emerged possible reliable biomarkers, they can be analyzed biological fluids patients at a low cost. This review explores IBDs IBS, focusing on their involvement control hallmarks. By an extensive literature employing bioinformatics tools, we identified frequently studied concerning diseases. Ultimately, specific could proposed diagnostic biomarkers for IBS. Their ability to secreted into biofluids makes them promising candidates non-invasive tools. Therefore, understanding molecular mechanisms through ways which regulate immune responses provide new insights pathogenesis open avenues miRNA-based therapeutic interventions.

Language: Английский

Citations

1
European Consensus on Malabsorption—UEG & SIGE, LGA, SPG, SRGH, CGS, ESPCG, EAGEN, ESPEN, and ESPGHAN. Part 1: Definitions, Clinical Phenotypes, and Diagnostic Testing for Malabsorption DOI Creative Commons
Marco Vincenzo Lenti, Heinz F. Hammer, Ilja Tachecí

et al.

United European Gastroenterology Journal, Journal Year: 2025, Volume and Issue: unknown

Published: March 25, 2025

Malabsorption is a complex and multifaceted condition characterised by the defective passage of nutrients into blood lymphatic streams. Several congenital or acquired disorders may cause either selective global malabsorption in both children adults, such as cystic fibrosis, exocrine pancreatic insufficiency (EPI), coeliac disease (CD) other enteropathies, lactase deficiency, small intestinal bacterial overgrowth (SIBO), autoimmune atrophic gastritis, Crohn's disease, gastric bowel resections. Early recognition key for tailoring proper diagnostic work-up identifying malabsorption. A patient's medical pharmacological history essential risk factors. examinations endoscopy with biopsies, non-invasive functional tests radiological imaging are useful diagnosing Because its high prevalence, CD should always be looked cases no obvious explanations high-risk individuals. Nutritional support management patients malabsorption; different options available, including oral supplements, enteral parenteral nutrition. In short syndrome, teduglutide proved effective reducing need nutrition, thus improving quality life these patients. Primary care physicians play central role early detection involved multidisciplinary teams overall this European consensus, involving ten scientific societies several experts, we have dissected all issues around malabsorption, definitions testing (Part 1), categories special populations, nutritional assessment management, primary perspective 2).

Language: Английский

Citations

0