The role of immunomodulators in severe mental disorders: future perspectives DOI

Bernhard T. Baune,

Sarah E. Fromme

Current Opinion in Psychiatry, Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 30, 2024

The immune system is of pivotal importance with regard to the development and maintenance mental illness. Aberrant cytokine levels are significant markers, research increasingly focusing on complement gut-brain axis. efficacy safety immunomodulatory interventions currently subject clinical studies. Hence, this review timeline relevant evaluate latest evidence value treatments from studies over past 18 months in schizophrenia, bipolar disorder unipolar depression.

Language: Английский

Ketamine treatment for anhedonia in unipolar and bipolar depression: a systematic review DOI
Aleksander Kwaśny, Julia Kwaśna, Alina Wilkowska

et al.

European Neuropsychopharmacology, Journal Year: 2024, Volume and Issue: 86, P. 20 - 34

Published: June 24, 2024

Language: Английский

Citations

6
Genetic causal relationship between multiple immune cell phenotypes and major depression disorder: a two sample bidirectional mendelian randomization study DOI
Xie Wang, Hong Chen, Juan Zhang

et al.

Current Psychology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 7, 2025

Language: Английский

Citations

0
Schaftoside Reduces Depression- and Anxiogenic-like Behaviors in Mice Depression Models DOI Creative Commons

Hu Yue,

Yaoxue Gan,

Lei Jia

et al.

Brain Sciences, Journal Year: 2025, Volume and Issue: 15(3), P. 238 - 238

Published: Feb. 24, 2025

Background: Major depressive disorder is a common mental health issue characterized by persistently low mood and high morbidity mortality. The major pathophysiology neuroinflammation, as evidenced elevated cytokine levels. Patients often fail to achieve full remission with the use of currently available antidepressants, prompting search for new treatment options. Schaftoside (SS), flavonoid found in traditional Chinese herbs, has both antioxidant anti-inflammatory properties. However, its antidepressant effects are poorly understood. Methods: Male C57BL/6 mice underwent chronic unpredictable mild stress (CUMS) lipopolysaccharide (LPS) induce depression- anxiety-like behaviors. SS was administered at 40, 80, 160 mg/kg 28 days. effect on depression-like behaviors assessed using behavioral assays, ELISA used measure pro-inflammatory cytokines serum hippocampus. Results: significantly decreased immobility forced swim tail suspension tests, increased sucrose preference test, reduced feeding latency novelty-suppressed test. These findings indicate improved depression showed that lowered interleukin-1 beta (IL-1β), IL-6, tumor necrosis factor-alpha levels hippocampus CUMS mice. Conclusions: Our study indicates anxiolytic effects, possibly through neuroinflammatory processes, making it promising therapeutic candidate depression, thus deserves further investigation into mechanisms clinical efficacy.

Language: Английский

Citations

0
Effects of esketamine on postoperative pain and inflammatory factors in children undergoing tonsillectomy and adenoidectomy DOI

yuchang zhu,

Xujian Wang, Lifeng Wang

et al.

Minerva Anestesiologica, Journal Year: 2025, Volume and Issue: 91(1-2)

Published: March 1, 2025

BACKGROUND: This study aimed to observe the effect of esketamine on postoperative pain and inflammatory factors in children undergoing tonsillectomy adenoidectomy.METHODS: Eighty scheduled for adenoidectomy were randomly divided into two groups using a random number table: an group (S-ketamine group, N.=40) control (control N.=40). The primary outcome was score, measured Face, Legs, Activity, Cry, Consolability (FLACC) scale score. Secondary outcomes include emergence agitation score (Pediatric Anesthesia Emergence Delirium [PAED]), operation time, recovery postanesthesia care unit (PACU) stay adverse reactions within 48 h after operation, plasma C-reactive protein (CRP) interleukin-6 (IL-6) concentrations.RESULTS: At T1, T2, T3, T4, T5, FLACC scores S-ketamine significantly lower than those (15 min: 2.4±0.7 vs. 3.4±0.8, P<0.01; 1 h: 1.7±0.6 2.2±0.7, 6 1.5±0.6 2.0±0.5, 12 1.8±0.7, P<0.05; 24 1.4±0.6 1.7±0.6, P<0.05). PAED at T1 T2 4.0±0.9 6.4±1.3, 2.1±0.5, P<0.01). Compared with T0, CRP IL-6 concentrations T3 increased (P<0.01), but increase smaller that (IL-6: 111.8±19.2 145.8±22.5, CRP: 1.2±0.5 1.5±0.5, other similar between groups.CONCLUSIONS: Esketamine used pediatric can effectively reduce FLACC, levels without increasing reactions.

Language: Английский

Citations

0
Effect of intraoperative intravenous esketamine on postoperative delirium in older patients undergoing hip fracture surgery: protocol for a randomised, double-blind, placebo-controlled trial DOI Creative Commons

Caoyang Shao,

Qianli Huang,

Weiyan Huang

et al.

BMJ Open, Journal Year: 2025, Volume and Issue: 15(3), P. e092159 - e092159

Published: March 1, 2025

Introduction Postoperative delirium (POD) is a common complication after hip fracture surgery in older patients. Esketamine may be beneficial alleviating the occurrence of POD. Our trial aim to investigate whether intravenous administration esketamine can improve POD patients undergoing for fracture. Methods and analysis This randomised controlled will conducted at Chengdu Integrated TCM & Western Medicine Hospital Chengdu, China. A total 260 scheduled under general anaesthesia randomly allocated either an group (group E) or control C) 1:1 ratio (n=130 each group). After tracheal intubation, E receive continuous infusion rate 0.3 mg/kg/h intraoperatively until beginning skin incision closure. Group C equivalent volumes rates 0.9% normal saline; injection methods are accordance with those E. The primary outcome incidence within 3 days surgery, which evaluated using confusion assessment method two times per day. Secondary outcomes subtypes, duration delirium, length hospital stay, pain severity score 30-day all-cause mortality. Pain scores rest numeric rating scale. Safety include hallucination, dizziness, nightmares, nausea vomiting. All analyses performed line intention-to-treat principle. Ethics dissemination approval was obtained from Medical Committee integrated (2024KT022). provide written informed consent before enrolment. results published appropriate journal oral presentation academic meetings. Trial registration number Chinese Clinical Registry (ChiCTR2400081681).

Language: Английский

Citations

0
Tabersonine ameliorates depressive-like behavior by inhibiting NLRP3 inflammasome activation in a mouse model DOI
Yan Shi, Yue Hu,

Yaoxue Gan

et al.

Neuropharmacology, Journal Year: 2025, Volume and Issue: unknown, P. 110432 - 110432

Published: March 1, 2025

Language: Английский

Citations

0
Esketamine mitigates systemic inflammation via modulating phenotypic transformation of monocytes in patients undergoing thoracic surgery DOI
Weiyun Shen, Yan Yan, Wenjuan Zhang

et al.

Life Sciences, Journal Year: 2025, Volume and Issue: unknown, P. 123594 - 123594

Published: March 1, 2025

Language: Английский

Citations

0
The rapid onset of response to depression treatment by Yueju Pill: from discovery of a novel treatment target to clinical perspective DOI Creative Commons
Ruiyi Liu,

Zhangjie Wu,

Ying Yin

et al.

Brain Behavior and Immunity Integrative, Journal Year: 2025, Volume and Issue: unknown, P. 100121 - 100121

Published: April 1, 2025

Language: Английский

Citations

0
High baseline plasma anthranilic acid predicts remission upon acute-series ketamine infusion for treatment-resistant depression DOI Creative Commons

Stephen Murata,

Zachary Madaj, Colt Capan

et al.

Biological Psychiatry Global Open Science, Journal Year: 2025, Volume and Issue: unknown, P. 100503 - 100503

Published: April 1, 2025

Language: Английский

Citations

0
Probiotic Bactolac alleviates depression-like behaviors by modulating BDNF, NLRP3 and MC4R levels, reducing neuroinflammation and promoting neural repair in rat model DOI Creative Commons
Musab Işık, Fadime Köse,

Özcan Budak

et al.

Pflügers Archiv - European Journal of Physiology, Journal Year: 2025, Volume and Issue: unknown

Published: April 26, 2025

Abstract Depression, a prevalent psychiatric disorder, exerts severe and debilitating impacts on an individual's mental physical well-being, it is considered chronic illness. Chronic stress plays important role in the pathophysiology of depression. Lactobacillus plantarum Streptococcus thermophilus are psychobiotic bacteria synthesize some neurotransmitters that play pathogenesis In this study, we aimed to investigate therapeutic effects Bactolac ( NBIMCC 8767 + 8258) stress-induced depression rats. Behavioral tests, including sucrose preference test, elevated plus maze forced swim three-chamber sociability were employed assess depressive anxiety-like behaviors. The expression level 5-HT1A, DRD1, ADRA-2A, GABA-A α1, CNR1, NR3C2, NOD1, NLRP3 MC4R; BDNF levels, glial activity intestinal permeability determined conclusions, decreased levels NOD1 level; increased MC4R, caused neurodegeneration activity, ultimately led effects. was effective reducing depressive-like behaviors according results behavioral tests. treatment provided high neuronal survival rate increasing level, prevented excessive release pro-inflammatory cytokines by therefore, activation hypothalamus–pituitary–adrenal (HPA) axis accordingly, reduced cell depressed We can suggest supplementation may be beneficial coping with stress, alleviate help protect health.

Language: Английский

Citations

0