Emerging perspectives on RNA virus-mediated infections: from pathogenesis to therapeutic interventions

World Journal of Virology, Journal Year: 2023, Volume and Issue: 12(5), P. 242 - 255

Published: Dec. 25, 2023

RNA viruses continue to pose significant threats global public health, necessitating a profound understanding of their pathogenic mechanisms and the development effective therapeutic interventions. This manuscript provides comprehensive overview emerging perspectives on virus-mediated infections, spanning from intricate intricacies viral pathogenesis forefront innovative strategies. A critical exploration antiviral drugs sets stage, highlighting diverse classes compounds that target various stages life cycle, underscoring ongoing efforts combat infections. Central this discussion is RNA-based therapeutics, with spotlight messenger (mRNA)-based approaches have revolutionized landscape Furthermore, delves into world delivery systems, exploring inno-vative technologies designed enhance efficiency safety mRNA vaccines. By analyzing challenges advancements in mechanisms, review offers roadmap for future research area. Beyond conventional infectious diseases, document explores expanding applications vaccines, including promising roles cancer immunotherapy personalized medicine approaches. serves as valuable resource researchers, clinicians, policymakers alike, offering nuanced perspective virus cutting-edge synthesizing latest challenges, contributes significantly discourse field, driving novel strategies infections effectively.

Language: Английский

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Early detection of SARS-CoV-2 with functionalized gold and molecularly imprinted polymeric nanoparticles: a mini review

Molecular Systems Design & Engineering, Journal Year: 2023, Volume and Issue: 8(11), P. 1337 - 1354

Published: Jan. 1, 2023

Numerous tests have been developed for early clinical detection of the novel coronavirus, COVID-19, including RT-PCR, rapid PCR, laminar flow tests, and large-scale decentralized screening SARS-CoV-2 in a point-of-care format.

Language: Английский

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Enhancement of the Signal Resolution in Aptamer Assay Upon Target Binding by Employing DNA Probes and Dual Fluorophores

Published: Jan. 1, 2024

Language: Английский

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Aptamer-decorated nanocarriers for viral adsorption: A special look at COVID-19

Molecular Therapy — Nucleic Acids, Journal Year: 2024, Volume and Issue: 35(3), P. 102310 - 102310

Published: Aug. 15, 2024

Viral infections are one of the leading causes death in world. One main challenge fighting against these diseases is unavailability effective eradicating drugs and specific treatments. Nanocarriers aptamer-decorated nanocarriers designed to attach many targets, including viral particles. By lowering infectivity attachment capability, they add therapeutic values even without containing antiviral drugs. Nevertheless, nanoparticles (NPs) with encapsulated can display extra effects. Furthermore, it has been shown that aptamers bind particles nanocarriers, presenting promising approaches for identification viruses treatment infections. Although there no satisfying literature revealing strong potential nanotechnology COVID-19, following information provide new perspectives upcoming investigations pertaining developing aptamer-nanocarrier agents COVID-19.

Language: Английский

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Enhancement of the signal resolution in aptamer assay upon target binding by employing DNA probes and dual fluorophores

Microchemical Journal, Journal Year: 2024, Volume and Issue: 207, P. 112065 - 112065

Published: Nov. 1, 2024

Language: Английский

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