Acanthus mollis Formulations for Transdermal Delivery: From Hydrogels to Emulsions DOI Creative Commons
Patrícia Matos, Maria Teresa Batista, Francisco Veiga

et al.

Gels, Journal Year: 2023, Volume and Issue: 10(1), P. 36 - 36

Published: Dec. 31, 2023

Topical formulations of Acanthus mollis L. leaf and the optimization release their active compounds topical bioavailability were investigated for first time. In vitro, from three formulations—an oil-in-water cream two hydrogels (Carbopol 940 Pluronic F-127)—was determined using Franz diffusion cells. Detection quantification was performed via high-performance liquid chromatography with a photodiode array (HPLC-PDA). DIBOA, bioactive compound this medicinal plant, exhibited kinetics Weibull model Carbopol F-127 formulation, identifying it as potential agent to optimize distribution formulations. The implications extend applications in inflammation treatment tyrosinase inhibition, suggesting that can make significant contribution addressing skin conditions, including melanoma various inflammatory diseases.

Language: Английский

Exploring industrial lignocellulosic waste: Sources, types, and potential as high-value molecules DOI Creative Commons
Elisabeth A. Cazier, Thanh‐Nhat Pham,

Louis Cossus

et al.

Waste Management, Journal Year: 2024, Volume and Issue: 188, P. 11 - 38

Published: Aug. 1, 2024

Lignocellulosic biomass has a promising role in circular bioeconomy and may be used to produce valuable molecules for green chemistry. biomass, such as food waste, agricultural wood, paper or cardboard, corresponded 15.7% of all waste produced Europe 2020, high potential secondary raw material industrial processes. This review first presents lignocellulosic sources, terms their composition, quantities types residues. Secondly, the possible added-value chemicals obtained from transformation are detailed, well applications industry, biomedical, energy chemistry sectors, including sources polyphenols, enzymes, bioplastic precursors biofuels. In third part, various available treatments, physical treatments with ultrasound heat, chemical acids bases, biological enzymes microorganisms, presented. The last part discusses perspectives use fact that decreasing cost is one major issues improving economy approach, since it currently often more expensive than petroleum-based counterparts.

Language: Английский

Citations

14
Fluorescent covalent organic framework as an ultrasensitive fluorescent probe for tyrosinase activity monitoring and inhibitor screening DOI
Hongmei Liu, Weiping Liu, Yue Li

et al.

Analytica Chimica Acta, Journal Year: 2024, Volume and Issue: 1320, P. 343026 - 343026

Published: July 26, 2024

Language: Английский

Citations

5
From Waste to Wealth: Exploring the Bioactive Potential of Wine By-Products—A Review DOI Creative Commons

Glenda-Caridad Peña-Portillo,

Sergio Acuña, José Miguel Bastías‐Montes

et al.

Antioxidants, Journal Year: 2024, Volume and Issue: 13(8), P. 992 - 992

Published: Aug. 15, 2024

The present paper explores the biological potential of bioactive compounds in wine industry wastes, highlighting their valorization to promote sustainability and circular economy. Wine by-products, such as grape pomace vine shoots, contain a high concentration polyphenols, flavonoids, anthocyanins other phytochemicals with antioxidant, anti-inflammatory anticarcinogenic properties. Both conventional extraction methods, solid-liquid extraction, emerging technologies, including enzyme-assisted ultrasound-assisted supercritical fluid microwave-assisted pressurized liquid high-hydrostatic-pressure deep natural solvent-assisted (NaDES), are discussed. In addition, preservation polyphenolic extracts by microencapsulation, key technique improve stability bioavailability compounds, is addressed. combination advanced methods innovative techniques offers promising perspective for from residues, driving innovation industry.

Language: Английский

Citations

4
A novel tyrosinase inhibitory peptide derived from Sipunculus nudus suppresses melanogenesis in B16F10 cells by down-regulating TRP-1/TRP-2 expression DOI
Yonghua Zhuang, Haisheng Lin,

Jialong Gao

et al.

Journal of Functional Foods, Journal Year: 2025, Volume and Issue: 129, P. 106872 - 106872

Published: May 2, 2025

Language: Английский

Citations

0
Environmental Factors Related to Climate Change Alter the Chemical Composition and Biological Activity of Lavandula viridis L’Hér Essential Oil DOI Creative Commons
Inês Mansinhos, Sandra Gonçalves, Raquel Rodríguez‐Solana

et al.

Agriculture, Journal Year: 2024, Volume and Issue: 14(7), P. 1067 - 1067

Published: July 2, 2024

Climate change is affecting all regions of the world, and Mediterranean region one most affected. Plants accumulate secondary metabolites as an adaptive response to stress circumstances. The present study investigated effect different abiotic factor conditions (drought, moderate heat, severe salinity, UV-B radiation) on essential oil (EO) yield, composition (volatile profile), biological activity (enzyme inhibition antioxidant activity) Lavandula viridis L’Hér. In general, environmental increased extraction yield EO. Eighty-two compounds were identified in EO factors induced some quantitative changes composition. Severe heat salinity concentration two abundant compounds, 1,8-cineole camphor. also potential inhibit enzymes butyrylcholinesterase tyrosinase. Drought, radiation promoted ability acetylcholinesterase. addition, drought enhanced These results are relevant for exploring this industrial applications, although future studies combining studied important understand influence synergistic effects bioactivity plant products obtained.

Language: Английский

Citations

3
Small-Molecule Tyrosinase Inhibitors for Treatment of Hyperpigmentation DOI Creative Commons

Xinhua Ni,

Xinyu Luo, Xiaoying Jiang

et al.

Molecules, Journal Year: 2025, Volume and Issue: 30(4), P. 788 - 788

Published: Feb. 8, 2025

Increasing attention is being focused on skin health currently, especially the excessive deposition of melanin in skin. Tyrosinase, rate-limiting enzyme biosynthesis, a crucial synthesis. However, existing tyrosinase inhibitors pose some degree toxicity to humans. Therefore, development more efficient and low-toxicity urgently needed. This review briefly depicts biosynthesis process crystal structure catalytic mechanism tyrosinase. The latest research progress regarding small-molecule also reviewed. Moreover, structure-function relationships are analyzed summarized. expected provide new scientific insights enable researchers explore safer potent inhibitors.

Language: Английский

Citations

0
Valorization of Grape Pomace Extract Through Dextran–Grape Conjugates: A Sustainable Approach for Cosmetic and Dermatological Applications DOI Creative Commons

Marisa Francesca Motta,

Anna Francesca Vattimo,

Fabio Amone

et al.

Applied Sciences, Journal Year: 2025, Volume and Issue: 15(6), P. 3220 - 3220

Published: March 15, 2025

Industrial waste management is a growing concern, and the valorization of by-products through circular economy approaches represents sustainable solution. In this context, dextran–grape conjugates (PLG–GRAPE) were obtained via grafting reaction grape pomace extract dextran under aqueous conditions. To compare properties polymeric graft with those free extract, total polyphenol content was assessed using Folin–Ciocalteu assay, along stability diffusion studies. addition, in vitro safety evaluations, including Neutral Red Uptake, h-CLAT, skin irritation tests performed to assess biocompatibility. evaluate antioxidant, anti-inflammatory, anti-aging PLG–GRAPE, efficacy assays on keratinocyte fibroblast cell lines full-thickness reconstructed human tissues exposed damaging agents, such as UV radiation pollutants. The results showed that technology preserved phenolic antioxidant activity while improving properties. As demonstrated by studies, favorable biocompatibility profile observed, addition significant capacity reduce oxidative stress inflammation aged cells, thus, attenuating cellular aging senescence. conclusion, study suggests PLG–GRAPE has potential bioactive ingredient for cosmetic dermatological applications, offering effective approach utilizing industrial products.

Language: Английский

Citations

0
Polyphenol Profile and Antioxidant, Antityrosinase, and Anti-Melanogenesis Activities of Ethanol Extract of Bee Pollen DOI Creative Commons
Qiang He, Jie Wang, Jingjing Li

et al.

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(12), P. 1634 - 1634

Published: Dec. 5, 2024

Background/Objective: Bee pollen, a rich nutritional food, was employed to develop raw material for skin whitening. Methods: The polyphenol profile and antioxidant, antityrosinase, anti-melanogenesis activities of the ethanol extracts five species bee pollens (EEBPs) were determined. Results: results showed that there total 121 phenolic compounds in these EEBPs. Each type pollen had unique substances. best activity observed sunflower EEBP, about 25% at concentration 25 μg/mL BEEP. EEBPs from high low sunflower, apricot, camellia, rapeseed, lotus B16F10 cells positively correlated with antityrosinase phenol content, coefficients 0.987 0.940. Kyoto Encyclopedia Genes Genomes enrichment analysis untargeted proteomics revealed EEBP inhibited melanogenesis by reducing expression proteins MAP2K1, NFKB2, RELB, RPS6KA3, CASP3, TRAF6, MAP2K5, MAPKAPK3, STRADA, CCNA2, FASN involved cAMP, MAPK, TNF signaling pathways, even though pathways not significantly different control group. Conclusions: has inhibition effect on than other provide basis future industrial development

Language: Английский

Citations

1
Naphthofuran-Triazoles As Effective Templates for Bacterial Tyrosinase Inhibition: BTEAC Catalyzed Ultrasound Assisted Synthesis, In Vitro Biological Evaluation and In Silico Validation DOI

Sadaf Saeed,

Asim Mansha, Ameer Fawad Zahoor

et al.

Journal of Molecular Structure, Journal Year: 2024, Volume and Issue: unknown, P. 141209 - 141209

Published: Dec. 1, 2024

Language: Английский

Citations

1
Acanthus mollis Formulations for Transdermal Delivery: From Hydrogels to Emulsions DOI Creative Commons
Patrícia Matos, Maria Teresa Batista, Francisco Veiga

et al.

Gels, Journal Year: 2023, Volume and Issue: 10(1), P. 36 - 36

Published: Dec. 31, 2023

Topical formulations of Acanthus mollis L. leaf and the optimization release their active compounds topical bioavailability were investigated for first time. In vitro, from three formulations—an oil-in-water cream two hydrogels (Carbopol 940 Pluronic F-127)—was determined using Franz diffusion cells. Detection quantification was performed via high-performance liquid chromatography with a photodiode array (HPLC-PDA). DIBOA, bioactive compound this medicinal plant, exhibited kinetics Weibull model Carbopol F-127 formulation, identifying it as potential agent to optimize distribution formulations. The implications extend applications in inflammation treatment tyrosinase inhibition, suggesting that can make significant contribution addressing skin conditions, including melanoma various inflammatory diseases.

Language: Английский

Citations

3