A Brief Chronicle of Antibody Research and Technological Advances DOI Creative Commons
Kazutaka Araki, Ryota Maeda

Antibodies, Journal Year: 2024, Volume and Issue: 13(4), P. 90 - 90

Published: Nov. 11, 2024

This review briefly traces the historical development of antibody research and related technologies. The path from early perceptions immunity to emergence modern immunotherapy has been marked by pivotal discoveries technological advances. Early insights into led vaccination serotherapy. elucidation structure function paved way for monoclonal technology its application in diagnosis therapy. Breakthroughs genetic engineering have enabled production humanized antibodies advances Fc engineering, thereby increasing therapeutic efficacy. discovery immune checkpoints cytokines revolutionized treatment cancer autoimmune diseases. field continues evolve rapidly with advent antibody-drug conjugates, bispecific antibodies, CAR T-cell therapies. As we face global health challenges, remains at forefront medical innovation offers promising solutions future.

Language: Английский

Small molecule modulators of Alpha-Synuclein Aggregation and Toxicity: Pioneering an Emerging Arsenal Against Parkinson’s Disease DOI
Ishfaq Ahmad Ahanger, Tanveer Ali Dar

Ageing Research Reviews, Journal Year: 2024, Volume and Issue: 101, P. 102538 - 102538

Published: Oct. 9, 2024

Language: Английский

Citations

5
Exploring immunotherapeutic strategies for neurodegenerative diseases: a focus on Huntington’s disease and Prion diseases DOI

Abhiyanta Mukherjee,

Soumojit Biswas,

Ipsita Roy

et al.

Acta Pharmacologica Sinica, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 31, 2025

Language: Английский

Citations

0
A comprehensive prognostic and immunological analysis of hexokinase domain containing protein-1 (HKDC1) in pan-cancer DOI Creative Commons
Zhi Liang, Tian-hao Zhang, Jiajia Huang

et al.

PeerJ, Journal Year: 2025, Volume and Issue: 13, P. e19083 - e19083

Published: March 19, 2025

Background Currently, research on the role of hexokinase domain-containing protein-1 (HKDC1) in neoplasm metabolism remains sparse. This study seeks to conduct a thorough investigation HKDC1’s potential functions across thirty-three different tumor types, utilizing data obtained from The Cancer Genome Atlas (TCGA). Method We conducted extraction TCGA database, subsequently employing R (version 4.2.2) and its associated software packages for detailed analysis. Our centered evaluating differential expression prognostic significance HKDC1, while also examining connections heterogeneity, mutation profiles, RNA modifications. Furthermore, we analyzed relationship between HKDC1 immunity TIMER analysis approach. Results A comprehensive various types has revealed that is significantly upregulated many malignant tumors. Importantly, patients with elevated levels their tissues often experience poorer prognoses. association expression, immune cell infiltration, existence checkpoints suggests possible connection microenvironment alongside advancement. Gene set enrichment (GSEA) further substantiates idea may play several critical pathways biological processes neoplasm. Additionally, overexpression influenced by promoter methylation alterations DNA copy number amplification. vitro experiments demonstrated silencing resulted marked reduction proliferation, migration, invasion capabilities cells. Conclusion initial pan-cancer provided understanding oncogenic roles diverse cancer types. Moreover, serve as significant biomarker.

Language: Английский

Citations

0
Advances in Understanding and Managing Alzheimer's Disease: From Pathophysiology to Innovative Therapeutic Strategies DOI

Sunny Rathee,

D. Sen, Vishal Pandey

et al.

Current Drug Targets, Journal Year: 2024, Volume and Issue: 25(11), P. 752 - 774

Published: July 23, 2024

: Alzheimer's disease (AD) is a debilitating neurodegenerative disorder characterized by the presence of amyloid-β (Aβ) plaques and tau-containing neurofibrillary tangles, leading to cognitive physical decline. Representing majority dementia cases, AD poses significant burden on healthcare systems globally, with onset typically occurring after age 65. While most cases are sporadic, about 10% exhibit autosomal forms associated specific gene mutations. Neurofibrillary tangles Aβ formed misfolded tau proteins peptides contribute neuronal damage impairment. Currently, approved drugs, such as acetylcholinesterase inhibitors N-methyl D-aspartate receptor agonists, offer only partial symptomatic relief without altering progression. A promising development using lecanemab, humanized IgG1 monoclonal antibody, an immune therapeutic approach. Lecanemab demonstrates selectivity for polymorphic variants binds large soluble aggregates, providing potential avenue targeted treatment. This shift in understanding role adaptive response pathogenesis opens new possibilities interventions aiming address disease's intricate mechanisms. review aims summarize recent advancements pathophysiology innovative approaches, valuable insights both researchers clinicians.

Language: Английский

Citations

2
Cyclodextrin-Containing Drug Delivery Systems and Their Applications in Neurodegenerative Disorders DOI Open Access

Yuan Xing,

Bohan Meng,

Qi Chen

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(19), P. 10834 - 10834

Published: Oct. 9, 2024

Cyclodextrins (CDs) are ubiquitous excipients, constituted of cyclic glucopyranose units, and possess a unique dual nature, that hydrophobic interior hydrophilic exterior. This enables their interaction with lipid-affinitive compounds compounds, thereby augmenting application in pharmaceutical formulations as agents for improving solubility, well fundamental elements advanced drug delivery systems. Additionally, CDs, upon suitable modification, can strategically participate the cellular components physical barriers, such blood–brain barrier, where intricate multifunctional engagement leads to various biological impacts. review consolidates crucial features CDs derivatives, summarizes applications them systems neurodegenerative disorders, emphasizing notable potentials.

Language: Английский

Citations

2
A Brief Chronicle of Antibody Research and Technological Advances DOI Creative Commons
Kazutaka Araki, Ryota Maeda

Antibodies, Journal Year: 2024, Volume and Issue: 13(4), P. 90 - 90

Published: Nov. 11, 2024

This review briefly traces the historical development of antibody research and related technologies. The path from early perceptions immunity to emergence modern immunotherapy has been marked by pivotal discoveries technological advances. Early insights into led vaccination serotherapy. elucidation structure function paved way for monoclonal technology its application in diagnosis therapy. Breakthroughs genetic engineering have enabled production humanized antibodies advances Fc engineering, thereby increasing therapeutic efficacy. discovery immune checkpoints cytokines revolutionized treatment cancer autoimmune diseases. field continues evolve rapidly with advent antibody-drug conjugates, bispecific antibodies, CAR T-cell therapies. As we face global health challenges, remains at forefront medical innovation offers promising solutions future.

Language: Английский

Citations

0