Thiourea Derivatives in Agrochemical Discovery and Development DOI
Yi Qi, Ping Sun, Xinyi Zhang

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Thiourea, represented by the chemical formula (R1R2N)(R3R4N)C═S, is a significant organic sulfur compound characterized presence of atom and two amino groups. Meanwhile, thiourea isothiourea are reciprocal isomers. This structure facilitates formation biologically active moiety, which interconnected through double bonds between nitrogen atoms. As potent component in pesticide formulations, demonstrates efficacy safeguarding crops against variety diseases inhibiting growth reproduction pathogens. review aims to provide comprehensive summary derivatives exhibiting fungicidal, insecticidal, antiviral, herbicidal, plant regulatory properties, with objective offering new perspectives for identifying innovative thiourea-based pesticides elucidating their mechanisms action.

Language: Английский

A patent review of hepatitis B virus core protein allosteric modulators (2019-present) DOI
Shuo Wang,

Fareeda Ma,

Kai Tang

et al.

Expert Opinion on Therapeutic Patents, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 22, 2025

Introduction The hepatitis B virus (HBV) core protein is a significant therapeutic target due to its essential role in HBV replication. Over the past five years, numerous structurally unique CpAMs have been patented. However, no compounds approved various issues such as poor pharmacokinetics (PK) and hepatotoxicity. As result, there an urgent need develop novel without these limitations.

Language: Английский

Citations

0
Thiourea Derivatives in Agrochemical Discovery and Development DOI
Yi Qi, Ping Sun, Xinyi Zhang

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 7, 2025

Thiourea, represented by the chemical formula (R1R2N)(R3R4N)C═S, is a significant organic sulfur compound characterized presence of atom and two amino groups. Meanwhile, thiourea isothiourea are reciprocal isomers. This structure facilitates formation biologically active moiety, which interconnected through double bonds between nitrogen atoms. As potent component in pesticide formulations, demonstrates efficacy safeguarding crops against variety diseases inhibiting growth reproduction pathogens. review aims to provide comprehensive summary derivatives exhibiting fungicidal, insecticidal, antiviral, herbicidal, plant regulatory properties, with objective offering new perspectives for identifying innovative thiourea-based pesticides elucidating their mechanisms action.

Language: Английский

Citations

0