Current Trends in Clinical Trials of Prodrugs

Pharmaceuticals, Journal Year: 2025, Volume and Issue: 18(2), P. 210 - 210

Published: Feb. 4, 2025

The development of new drugs is a lengthy and complex process regarding its conception ideation, passing through in silico studies, synthesis, vivo clinical trials, approval, commercialization, with an exceptionally low success rate. lack efficacy, safety, suboptimal pharmacokinetic parameters are commonly identified as significant challenges the discovery drugs. To help address these challenges, various approaches have been explored medicinal chemistry, including use prodrug strategies. As well-established approach, design remains best option for improving physicochemical properties, reducing toxicity, increasing selectivity, all while minimizing costs saving on biological studies. This review article aims to analyze current advances using approach that has allowed advance drug candidates trials last 10 years. presented here aim inspire further molecular optimization processes highlight potential this strategy facilitate advancement compounds study phases.

Language: Английский

Discovery and proof-of-concept study of a novel highly selective sigma-1 receptor agonist for antipsychotic drug development

Acta Pharmaceutica Sinica B, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский