Advancements and challenges in personalized neoantigen-based cancer vaccines DOI Creative Commons

Parminder Singh,

Mahalaqua Nazli Khatib,

R Roopashree

et al.

Oncology Reviews, Journal Year: 2025, Volume and Issue: 19

Published: March 14, 2025

Advancements in personalized neoantigen-based cancer vaccines are ushering a new era oncology, targeting unique genetic alterations within tumors to enhance treatment precision and efficacy. Neoantigens, specific cells absent normal tissues, at the heart of these vaccines, promising direct immune system specifically against tumor, thereby maximizing therapeutic efficacy while minimizing side effects. The identification neoantigens through genomic proteomic technologies is central developing allowing for precise mapping tumor's mutational landscape. Despite advancements, accurately predicting which will elicit strong responses remains challenging due tumor variability complexity interactions. This necessitates further refinement bioinformatics tools predictive models. Moreover, heavily depends on innovative delivery methods that neoantigen presentation system. Techniques like encapsulating lipid nanoparticles using viral vectors critical improving vaccine stability delivery. Additionally, contribute towards achieving Sustainable Development Goal 3.8, promoting universal health coverage by advancing access safe effective treatments. review delves into potential transform treatment, examining both revolutionary advancements ongoing challenges they face.

Language: Английский

Advancements and challenges in personalized neoantigen-based cancer vaccines DOI Creative Commons

Parminder Singh,

Mahalaqua Nazli Khatib,

R Roopashree

et al.

Oncology Reviews, Journal Year: 2025, Volume and Issue: 19

Published: March 14, 2025

Advancements in personalized neoantigen-based cancer vaccines are ushering a new era oncology, targeting unique genetic alterations within tumors to enhance treatment precision and efficacy. Neoantigens, specific cells absent normal tissues, at the heart of these vaccines, promising direct immune system specifically against tumor, thereby maximizing therapeutic efficacy while minimizing side effects. The identification neoantigens through genomic proteomic technologies is central developing allowing for precise mapping tumor's mutational landscape. Despite advancements, accurately predicting which will elicit strong responses remains challenging due tumor variability complexity interactions. This necessitates further refinement bioinformatics tools predictive models. Moreover, heavily depends on innovative delivery methods that neoantigen presentation system. Techniques like encapsulating lipid nanoparticles using viral vectors critical improving vaccine stability delivery. Additionally, contribute towards achieving Sustainable Development Goal 3.8, promoting universal health coverage by advancing access safe effective treatments. review delves into potential transform treatment, examining both revolutionary advancements ongoing challenges they face.

Language: Английский

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