A moderated mediation model in assessing links between rumination, emotional reactivity, and suicidal risk in alcohol use disorder DOI Creative Commons
Mateusz Wojtczak, Karol Karasiewicz, Katarzyna Kucharska

et al.

Frontiers in Psychiatry, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 28, 2025

Introduction Suicide is a major public health concern, particularly among people with alcohol use disorders (AUD). Rumination, as dysfunctional emotion regulation strategy, and increased emotional reactivity may significantly influence suicide risk in this population. Aim The aim of study was to assess whether different mediate the association between ruminations risk, AUD or control group (HC) status moderates these relationships. Methods A conducted 152 participants, including 86 from 66 HC. Self-report questionnaires measuring ruminations, were used. Structural Equation Modeling, invariance analysis, moderated mediation estimation used analyses. Results analysis full sample revealed significant indirect effect rumination on via reactivity. Multi-group indicated no differences HC groups, neither showing statistically effect. Conclusions findings indicate that serve key mechanism mediating relationship risk. Therapeutic interventions should focus reducing effectively reduce group. Further research needed better understand mechanisms.

Language: Английский

Prevalence of comorbid substance use in major depressive disorder in community and clinical settings, 1990–2019: Systematic review and meta-analysis DOI
Glenn E. Hunt, Gin S. Malhi, Harry Man Xiong Lai

et al.

Journal of Affective Disorders, Journal Year: 2020, Volume and Issue: 266, P. 288 - 304

Published: Jan. 26, 2020

Language: Английский

Citations

197

Annual Research Review: Defining and treating pediatric treatment‐resistant depression DOI

Jennifer B. Dwyer,

Argyris Stringaris, David A. Brent

et al.

Journal of Child Psychology and Psychiatry, Journal Year: 2020, Volume and Issue: 61(3), P. 312 - 332

Published: Feb. 4, 2020

Background Adolescent major depressive disorder (MDD) is a significant health problem, associated with substantial morbidity, cost, and mortality. Depression risk factor for suicide, which now the second leading cause of death in young people. Up to twenty per cent adolescents will experience MDD before adulthood, while proportion improve standard‐of‐care treatments (psychotherapy medication), roughly one third not. Methods Here, we have reviewed literature order discuss concept treatment‐resistant depression (TRD) adolescence, examine factors, diagnostic difficulties, challenges evaluating symptom improvement, providing guidance on how define adequate medication psychotherapy treatment trials. Results We propose staging model adolescent TRD review literature. The evidence base first‐ second‐line primarily derives from four large pediatric clinical trials (TADS, TORDIA, ADAPT, IMPACT). After two medications trial evidence‐based failed alleviate symptoms, becomes quite thin subsequent treatments. effectiveness switches, augmentation, interventional (i.e., transcranial magnetic stimulation, electroconvulsive therapy, ketamine) TRD. Comparisons are drawn adult literature, areas future research highlighted. Conclusions As limited this population, careful consideration known risks side effects escalated (e.g., mood stabilizers atypical antipsychotics) warranted weighed against potential, but often untested, benefits.

Language: Английский

Citations

87

Patterns of Multimorbidity in a Population-Based Cohort of Older People: Sociodemographic, Lifestyle, Clinical, and Functional Differences DOI Creative Commons
Alessandra Marengoni, Albert Roso‐Llorach, Davide Liborio Vetrano

et al.

The Journals of Gerontology Series A, Journal Year: 2019, Volume and Issue: unknown

Published: May 24, 2019

The aim of this study is to identify clusters older persons based on their multimorbidity patterns and analyze differences among according sociodemographic, lifestyle, clinical, functional characteristics. We analyzed data from the Swedish National Study Aging Care in Kungsholmen 2,931 participants aged 60 years who had at least two chronic diseases. Participants were clustered by fuzzy c-means cluster algorithm. A disease was considered be associated with a given when observed/expected ratio ≥2 or exclusivity ≥25%. Around half could classified into five clinically meaningful clusters: respiratory musculoskeletal diseases (RESP-MSK) 15.7%, eye cancer (EYE-CANCER) 10.7%, cognitive sensory impairment (CNS-IMP) 10.6%, heart (HEART) 9.3%, psychiatric (PSY-RESP) 5.4%. Individuals CNS-IMP oldest, worst function more likely live nursing home; those HEART highest number co-occurring drugs, they exhibited mean values serum creatinine C-reactive protein. PSY-RESP higher levels alcoholism neuroticism. other cohort grouped an unspecific cluster, which characterized gathering youngest individuals, lowest diseases, best status. identified provide insight for setting targets secondary tertiary preventative interventions designing care pathways multimorbid people.

Language: Английский

Citations

81

Addiction, Anhedonia, and Comorbid Mood Disorder. A Narrative Review DOI Creative Commons

Marianne Destoop,

Manuel Morrens, Violette Coppens

et al.

Frontiers in Psychiatry, Journal Year: 2019, Volume and Issue: 10

Published: May 22, 2019

Background: Recently, anhedonia has been recognized as an important Research Domain Criterion (RDoC) by the National Institute of Mental Health. Anhedonia is proposed to play essential role in pathogenies both addictive and mood disorders, possibly their co-occurrence with a single individual. However, up now, comprehensive information about concerning its underlying neurobiological circuitries, neurocognitive correlates, addiction, disorder, comorbidity remains scarce. Aim: In this literature review human studies, we bring together current state knowledge respect relationship disorders use substances (DUS) disorders. Method: A PubMed search was conducted using following terms: (Anhedonia OR Reward Deficiency) AND ((Drug Dependence Abuse) Alcohol Nicotine Addiction Gambling (Internet Gaming)). Thirty-two articles were included review. Results: associated substance severity especially prominent DUS comorbid depression. may be trait dimension relation tends impact treatment outcome negatively.

Language: Английский

Citations

67

The Cambridge Handbook of Substance and Behavioral Addictions DOI Open Access
Steve Sussman, Steve Sussman, Wilson M. Compton

et al.

Cambridge University Press eBooks, Journal Year: 2020, Volume and Issue: unknown

Published: July 13, 2020

Written by leaders in the addictions field, 100 authors from six countries, this handbook is a thoroughly comprehensive resource. Philosophical and legal issues are addressed, while conceptual underpinnings provided through explanations of appetitive motivation, incentive sensitization, reward deficiency, behavioral economics theories. Major clinical research methods clearly mapped out (e.g. MRI, economics, interview assessments, qualitative approaches), outlining their strengths weaknesses, giving reader tools needed to guide practice aims. The etiology addiction at various levels analysis discussed, including neurobiology, cognition, groups, culture, environment, which simultaneously lays foundations high-level discourse serve both novice expert researchers clinicians. Importantly, volume explores prevention treatment such as alcohol, tobacco, novel drugs, food, gambling, sex, work, shopping, internet, several seldom-investigated behaviors love, tanning, or exercise).

Language: Английский

Citations

63

Brain-behavior relations and effects of aging and common comorbidities in alcohol use disorder: A review. DOI Creative Commons
Edith V. Sullivan, Adolf Pfefferbaum

Neuropsychology, Journal Year: 2019, Volume and Issue: 33(6), P. 760 - 780

Published: Aug. 26, 2019

Alcohol use disorder (AUD) is a complex, dynamic condition that waxes and wanes with unhealthy drinking episodes varies in patterns effects on brain structure function age. Its excessive renders chronically heavy drinkers vulnerable to direct alcohol toxicity variety of comorbidities attributable nonalcohol drug misuse, viral infections, accelerated or premature aging. AUD affects widespread systems, commonly, frontolimbic, frontostriatal, frontocerebellar networks.

Language: Английский

Citations

60

Alcohol consumption and sleep quality: a community-based study DOI
Dandan Zheng, Xiaodong Yuan, Chaoran Ma

et al.

Public Health Nutrition, Journal Year: 2020, Volume and Issue: 24(15), P. 4851 - 4858

Published: Nov. 13, 2020

Abstract Objective: To assess the association between total alcohol intake, specific alcoholic beverages and sleep quality in a community-based cohort. Design: A cross-sectional study. Setting: The Kailuan community, China. Participants: Included were 11 905 participants who free of history CVD, cancer, Parkinson’s disease, dementia head injury or prior to 2012. Alcohol consumption (amount frequency intake) beverage type collected 2006 (baseline) Participants grouped into non-, light- (women: 0–0·4 serving/d; men: 0–0·9 serving/d), moderate- 0·5–1·0 1·0–2·0 servings/d) heavy- >1·0 servings/d; >2·0 drinkers. Overall was measured 2012 included four parameters (insomnia, daytime sleepiness, duration, snoring/obstructive apnoea). Results: We observed dose–response higher worse ( P trend < 0·001), after adjusting for age, sex, socio-economic status, smoking physical activity, obesity, plasma lipid profiles, diabetes hypertension. similar when used as exposure. associated with odds having short duration (adjusted OR v . non-drinkers = 1·31; 95 % CI: 1·09, 1·57) snoring non-drinkers: 1·38; 1·22, 1·57). Consumption hard liquor, but not beer wine, significantly poor quality. Conclusions: Higher poorer duration.

Language: Английский

Citations

51

The Prevention and Treatment of Gambling Disorders: Some Art, Some Science DOI
Jeffrey L. Derevensky

Cambridge University Press eBooks, Journal Year: 2020, Volume and Issue: unknown, P. 241 - 253

Published: Aug. 31, 2020

The landscape of gambling has dramatically changed. In addition to more and jurisdictions having casinos, electronic machines, lotteries sports wagering in close proximity individuals, online increased. Gambling moved from being a negatively perceived activity associated with sin vice its current state viewed as socially acceptable recreational pastime. Upwards 80 percent individuals report gambled for money during their lifetime, governments throughout the world have come recognize that regulated forms can be significant source revenue. While vast majority no gambling-related issues, an identifiable proportion both adults adolescents experience problems. spite growing body research which identified many risk protective factors excessive problematic gambling, limited number prevention treatment programs exist. This chapter examines knowledge concerning efficacy existing harm minimization disorders.

Language: Английский

Citations

46

Behavioral Economic Considerations of Novel Addictions and Nonaddictive Behavior: Research and Analytic Methods DOI
Derek D. Reed, Gideon P. Naudé, Brett W. Gelino

et al.

Cambridge University Press eBooks, Journal Year: 2020, Volume and Issue: unknown, P. 73 - 86

Published: Aug. 31, 2020

Behavioral economics is a subfield of behavioral psychology that integrates microeconomic principles with the experimental analysis behavior. Decades economic work have identified two concepts robustly related to issues risky health decisions and addictions: discounting operant demand. Discounting phenomenon wherein uncertain or delayed outcomes lose value, often resulting in myopic (e.g., choosing short-term benefits heroin use over long-term healthy behaviors). Operant demand describes organisms' persistent efforts maintain access reward. Collectively, comprise reinforcement pathology model unhealthy behavior, counterproductive excessive coalesce render reward preferences. This may help explain addictions, dependence, other issues. chapter history demand, common tasks derive indices hypothetical purchasing task, range applications novel nonaddictive behaviors literature, date.

Language: Английский

Citations

46

Mindfulness-Based Interventions Applied to Addiction Treatments DOI
Afton Kechter, David S. Black

Cambridge University Press eBooks, Journal Year: 2020, Volume and Issue: unknown, P. 409 - 417

Published: Aug. 31, 2020

Mindfulness-based interventions (MBIs), founded on the meditation practices outlined in Mindfulness-Based Stress Reduction (MBSR) program and historically rooted contemplative traditions, offer one mental framework to address unique needs of individuals suffering from causes consequences substance behavioral addictions. MBIs are considered a third wave empirically tested psychotherapies following therapy cognitive-behavioral therapy, respectively. MBI-proposed targets change include self-regulation, self-exploration, self-liberation; together, an important set capacities or skills break cycle addiction. In this chapter, we describe development adapted for variety We focus use disorders (SUD) binge-eating disorder (BED) due similarities addictive neurobiological processes (both may be addictions, BED as proxy food addiction), though other addictions also discussed. then critically review leading experimental trials that test efficacy mechanisms addiction behavior among people diagnosed with SUD BED. Based results available date, treatment effects par clinically accepted treatments. However, several methodological limitations make interpretation internal validity reliability these difficult assess. discuss strengths state evidence date provide suggestions future research emphasis fidelity its role improving study findings. expect our synthesis inform public value applying remediate behavior.

Language: Английский

Citations

44