Influence of binge drinking on the resting state functional connectivity of university Students: A follow-up study

Addictive Behaviors Reports, Journal Year: 2025, Volume and Issue: 21, P. 100585 - 100585

Published: Jan. 10, 2025

Binge Drinking (BD) is characterized by consuming large amounts of alcohol on one occasion, posing risks to brain function. Nonetheless, it remains the most prevalent consumption pattern among students. Cross-sectional studies have explored relationship between BD and anomalies in resting-state functional connectivity (RS-FC), but medium/long-term consequences RS-FC during developmental periods remain relatively unexplored. In this two-year follow-up study, impact sustained was investigated 44 college students (16 binge-drinkers) via two fMRI sessions at ages 18-19 20-21. Using a seed-to-voxel approach, differences were examined nodes main networks vulnerable misuse, according previous studies. Group observed four regions. drinkers, compared control group, exhibited, second assessment, decreased right SFG (executive network) precentral gyrus, ACC (salience postcentral left amygdala (emotional medial frontal gyrus/dorsal ACC. Conversely, binge drinkers showed increased Nacc (reward clusters comprising bilateral middle gyrus (MFG), cingulate cortex, MFG extending SFG. Maintaining critical neurodevelopmental years impacts RS-FC, indicating mid-to-long-term alterations organization. This study provides new insights into neurotoxic effects adolescent emphasizing need for longitudinal addressing lasting connectivity.

Language: Английский

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Atrophy and Higher Levels of Inflammatory‐Related Markers in the Posterior Cerebellar Lobe Cortex in Chronic Alcohol Use Disorder: A Cross‐Sectional Study

Neuropathology and Applied Neurobiology, Journal Year: 2025, Volume and Issue: 51(2)

Published: March 26, 2025

Alcohol use disorder (AUD) involves excessive and chronic ethanol consumption, leading to various health issues, including cerebellar atrophy. The cerebellum is particularly susceptible ethanol-induced damage through neuroinflammation, oxidative stress excitotoxicity. This has been documented predominantly in the anterior lobe, primarily due its role motor function, which often impaired patients with AUD. However, less known about impact of AUD on posterior lobes. In contrast, alterations lobe have associated cognitive affective syndrome (CCAS). Moreover, an asymmetric structure spatial functions being left-lateralised. We hypothesised that cases would show increased inflammation compared healthy controls. cross-sectional study examined structural integrity neuroinflammatory state left cortex post-mortem samples from nine males 9 control cases. Chronic showed significant damage. Immunohistochemistry revealed higher levels reactive astrogliosis (GFAP), Treg cell markers (CD45 FOXP3), mitochondria marker (MitoTrackerTM), elevated COX2 (indicating activity), cFos protein (cell activity marker), caspase 3 (Casp3) levels, suggesting death. These findings indicate leads atrophy neuroinflammation driven by astrogliosis, infiltration, activity. highlights inflammatory consequences AUD, potentially linked subsequent impairments. Targeting could help mitigate neurodegenerative effects

Language: Английский

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Exploratory study of associations between monetary reward anticipation brain responses and mu-opioid signalling in alcohol dependence, gambling disorder and healthy controls

Neuroimage Reports, Journal Year: 2024, Volume and Issue: 4(3), P. 100211 - 100211

Published: June 28, 2024

Alcohol dependence (AD) and gambling disorder (GD) are common addiction disorders with significant physical mental health consequences. AD GD associated dysregulated responses to reward which could be due a mechanism of endogenous opioid signalling. We explored associations between anticipation responses, using the Monetary Incentive Delay (MID) functional magnetic resonance imaging (fMRI) task, mu-opioid receptor (MOR) availability release capacity [

Language: Английский

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The Brain Salience Network at the Intersection of Pain and Substance use Disorders: Insights from Functional Neuroimaging Research

Current Addiction Reports, Journal Year: 2024, Volume and Issue: 11(5), P. 797 - 808

Published: July 29, 2024

The brain's salience network (SN), primarily comprising the anterior insula and cingulate cortex, plays a key role in detecting salient stimuli processing physical socioemotional pain (e.g., social rejection). Mounting evidence underscores an altered SN etiology maintenance of substance use disorders (SUDs). This paper aims to synthesize recent functional neuroimaging research emphasizing SN's involvement SUDs physical/socioemotional explore therapeutic prospects targeting for SUD treatment.

Language: Английский

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Neuroimaging biomarkers of addiction

Nature Mental Health, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 18, 2024

Language: Английский

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