Clinical Microbiology and Infection,
Journal Year:
2024,
Volume and Issue:
30(10), P. 1312 - 1318
Published: June 25, 2024
ObjectivesAmong
people
receiving
opioid-agonist
treatment
(OAT),
the
risk
of
COVID-19
infection
and
disease
may
be
higher
owing
to
underlying
health
problems
vulnerable
social
circumstances.
We
aimed
determine
whether
recent
OAT,
when
compared
with
past
exposure,
affected
(i)
testing
for
SARS-CoV-2,
(ii)
positive
(iii)
being
hospitalized
or
dying
disease.MethodsWe
included
individuals
prescribed
OAT
in
Scotland
from
2015
2020.
performed
record
linkage
SARS-CoV-2
PCR
testing,
vaccination,
hospitalization,
mortality
data,
followed
up
March
2020
December
2021.
used
proportional
hazards
analysis
multivariate
logistic
regression
estimate
associations
between
prescription
(in
previous
2
months),
exposure
(off
over
a
year),
outcomes.
Models
were
adjusted
confounders.ResultsAmong
36
093
19
071
(52.9%)
tested
SARS-CoV-2;
2896
(8.3%)
positive;
552
(1.5%)
died
COVID-19.
Recent
was
associated
lower
odds
among
those
(aOR,
0.63;
95%
CI,
0.57–0.69).
However,
positive,
two-fold
hospitalization
death
2.04;
1.60–2.59).DiscussionWe
found
that
infection,
but
once
diagnosed.
Clinical
studies
are
needed
unravel
role
these
associations.
An
enhanced
effort
is
warranted
increase
vaccine
coverage
patients
mitigate
severe
consequences
Harm Reduction Journal,
Journal Year:
2021,
Volume and Issue:
18(1)
Published: Nov. 24, 2021
Abstract
Background
While
people
who
inject
drugs
(PWID)
are
vulnerable
to
the
adverse
outcomes
of
events
like
COVID-19,
little
is
known
regarding
impact
current
pandemic
on
PWID.
We
examine
how
COVID-19
has
affected
PWID
in
New
York
City
across
four
domains:
substance
use,
risk
behaviors,
mental
health,
and
service
utilization.
Methods
As
part
a
randomized
trial
improve
access
HCV
treatment
for
PWID,
we
recruited
165
participants.
Eligibility
criteria
included
detectable
RNA
recent
drug
injection.
The
present
cross-sectional
analysis
based
subsample
106
compared
responses
between
two
separate
samples:
60
participants
interviewed
prior
(pre-COVID-19
sample)
46
during
(COVID-19
sample).
also
assessed
differences
by
study
group
[accessible
care
(AC)
usual
(UC)].
Results
Compared
pre-COVID-19
sample,
those
reported
higher
levels
health
issues,
syringe
reuse,
alcohol
consumption
greater
reductions
syringe-service
programs
buprenorphine
In
conducted
group,
UC
significantly
injection
behaviors
lower
while
same
period,
AC
use
behaviors.
Conclusion
provides
insight
negatively
Placing
dispensing
machines
harm-reduction
supplies
communities
where
live
increasing
secondary
exchange,
mobile
services,
mail
delivery
may
help
maintain
lifesaving
big
events,
such
as
COVID-19.
Trial
registration
ClinicalTrials.gov
NCT03214679.
Registered
July
11
2017.
https://clinicaltrials.gov/ct2/show/NCT03214679
.
Harm Reduction Journal,
Journal Year:
2022,
Volume and Issue:
19(1)
Published: July 2, 2022
Abstract
Background
Fatal
drug
overdoses
in
the
USA
hit
historical
records
during
COVID-19
pandemic.
Throughout
pandemic,
people
who
used
drugs
had
greater
odds
of
contracting
COVID-19,
increased
use
due
to
COVID-related
stress,
and
heightened
levels
anxiety
depression.
This
qualitative
study
examined
specific
ways
pandemic
negatively
impacted
drugs.
Methods
Qualitative
interviews
with
24
20
substance
harm
reduction
workers
were
conducted.
Data
from
analyzed
using
applied
thematic
analysis
identify
emergent
themes
based
on
a
priori
research
goals.
Results
Thematic
identified
several
common
experiences
among
These
included
mental
distress
financial
strain
social
isolation;
use;
risky
drug-seeking
behaviors
changes
markets;
reduced
access
reduction,
treatment,
recovery
support
services.
Conclusions
Our
highlighted
critical
systemic
failures
that
contributed
rise
overdose
deaths
Addressing
these
challenges
through
policy
reform
improved
funding
models
will
ensure
sustainability
services
increase
treatment
highly
vulnerable
Substance Abuse Treatment Prevention and Policy,
Journal Year:
2023,
Volume and Issue:
18(1)
Published: Sept. 30, 2023
Abstract
Background
The
COVID-19
pandemic
led
to
an
unprecedented
relaxation
of
restrictions
on
take-home
doses
in
opioid
agonist
treatment
(OAT).
We
conducted
a
mixed
methods
systematic
review
explore
the
impact
these
changes
program
effectiveness
and
client
experiences
OAT.
Methods
protocol
for
this
was
registered
PROSPERO
(CRD42022352310).
From
Aug.–Nov.
2022,
we
searched
Medline,
Embase,
CINAHL,
PsycInfo,
Web
Science,
Cochrane
Register
Controlled
Trials,
grey
literature.
included
studies
reporting
quantitative
measures
retention
treatment,
illicit
substance
use,
overdose,
health,
quality
life,
or
satisfaction
using
qualitative
examine
with
during
pandemic.
critically
appraised
Mixed
Appraisal
Tool.
synthesized
data
vote-counting
by
direction
effect
presented
results
harvest
plots.
Qualitative
were
analyzed
thematic
synthesis.
used
convergent
segregated
approach
integrate
findings.
Results
Forty
included.
Most
from
North
America
(23/40)
United
Kingdom
(9/40).
synthesis
limited
potential
confounding,
but
suggested
association
between
increased
treatment.
There
no
evidence
use
overdose.
findings
indicated
that
reduced
clients’
exposure
unregulated
substances
stigma
minimized
work/treatment
conflicts.
Though
some
clients
reported
challenges
managing
their
medication,
dominant
narrative
one
appreciation,
anxiety,
renewed
sense
agency
identity.
integrated
analysis
burden
as
explanation
improved
revealed
variation
individual
relationships
use.
identified
critical
gap
patient-important
outcomes.
Conclusion
associated
experience
found
despite
expansion
previously
ineligible
groups.
Including
outcome
policy,
development,
planning
is
essential
ensuring
decisions
around
accurately
reflect
value
clients.
International Journal of Drug Policy,
Journal Year:
2022,
Volume and Issue:
106, P. 103752 - 103752
Published: May 27, 2022
People
Who
Inject
Drugs
(PWID)
are
subject
to
distinct
socio-structural
inequalities
that
can
expose
them
high
risks
of
COVID-19
transmission
and
related
health
social
complications.
In
response
mitigation
strategies,
these
vulnerabilities
being
experienced
in
the
context
adapted
drug
treatment
service
provision,
including
reduced
in-person
support
increased
regulatory
flexibility
opioid
substitution
therapy
(OST)
guidelines.
This
study
aimed
explore
longer-term
impact
pandemic
on
wellbeing
PWID
UK,
provider
client
experiences
changes.Interviews
were
conducted
with
19
17
providers
between
May
September
2021,
recruited
from
homelessness
charities
providing
services
healthcare
UK.
Data
analysed
using
reflexive
thematic
analysis.Most
participants
expressed
ongoing
fears
transmission,
although
limited
contexts
which
physical
distancing
could
be
practised.
addition,
virus
strategies
altered
risk
environment
for
PWID,
resulting
(e.g.
changing
use
patterns,
transitions
crack
cocaine,
benzodiazepine
pregabalin
use)
socio-economic
harms
opportunities
sex
work
engagement
income
generation).
Finally,
whilst
clients
reported
some
favourable
adaptations
prompted
by
COVID-19,
OST
guidelines,
there
was
continued
scepticism
caution
among
toward
sustaining
any
changes
beyond
period.Whilst
our
findings
emphasize
importance
accessible
harm
reduction
measures
attending
indices
drug-related
during
this
period,
is
a
need
additional
structural
supports
ensure
pre-existing
disparities
impacting
not
exacerbated
further
conditions
pandemic.
sustained
policy
delivery
will
require
attention
if
they
acceptable
both
users
providers.
International Journal of Drug Policy,
Journal Year:
2022,
Volume and Issue:
110, P. 103877 - 103877
Published: Oct. 4, 2022
The
coronavirus
pandemic
resulted
in
many
changes
which
had
the
potential
to
impact
mortality
related
opioid
agonist
therapy
(OAT;
methadone,
buprenorphine),
including
prescribing
and
dispensing
of
OAT
patterns
drug
availability
use.
We
aimed
assess
first
lockdown
(initiated
March
23rd
2020)
on
methadone-
buprenorphine-related
deaths
England
people
both
prescribed
not
using
data
from
National
Programme
Substance
Abuse
Deaths.This
was
a
retrospective
post-mortem
toxicology
study
OAT-related
occurred
3-month
period
June
22nd
years
2016-2020.
Provisional
regarding
numbers
accessing
treatment
for
use
disorder
provided
by
Drug
Treatment
Monitoring
System.We
found
64%
increase
methadone-related
2020
compared
2019
(2019
n
=
96;
projected
157).
There
were
increases
rate
in-treatment
decedents
(22%
increase;
45;
an
exponential
smoothing
model
2016-19
trend
[α=0.5]
predicted
44
2020,
55
reported)
methadone
(74%
46;
43
80
reported).
no
9/529;
11/566).
where
other
opioids
or
multiple
substances
detected,
levels
detected.
Numbers
did
decrease
relative
previous
(p
>0.05).Methadone-related
non-prescribed
individuals,
but
increased
considerably
above
annual
forecast
during
COVID-19
England.
Further
studies
are
thus
needed
understand
this
difference.
BMC Public Health,
Journal Year:
2023,
Volume and Issue:
23(1)
Published: April 3, 2023
Abstract
Background
Despite
the
implementation
and
expansion
of
public
health
harm
reduction
strategies
aimed
at
preventing
reversing
overdoses,
rates
overdose-related
events
fatalities
continue
to
rise
in
British
Columbia.
The
COVID-19
pandemic
created
a
second,
concurrent
emergency
that
further
exacerbated
illicit
drug
toxicity
crisis,
reinforced
existing
social
inequities
vulnerabilities,
highlighted
precariousness
systems
place
are
meant
protect
communities.
By
exploring
perspectives
people
with
recent
experience
substance
use,
this
study
sought
characterize
how
associated
measures
influenced
risk
protective
factors
related
unintentional
overdose
by
altering
environment
which
live
use
substances,
influencing
ability
who
substances
be
safe
well.
Methods
One-on-one
semi-structured
interviews
were
conducted
phone
or
in-person
(n
=
62)
across
province.
Thematic
analysis
was
performed
identify
shaping
environment.
Results
Participants
pointed
increased
overdose,
including:
[1]
physical
distancing
isolation
led
more
alone
without
bystanders
nearby
able
respond
event
an
emergency;
[2]
early
price
spikes
supply
chain
issues
inconsistencies
availability;
[3]
increasing
impurities
unregulated
substances;
[4]
restriction
services
distribution
sites;
[5]
additional
burden
placed
on
peer
workers
frontlines
crisis.
these
challenges,
participants
protected
against
substance-related
harm,
including
emergence
new
programs,
resiliency
communities
expanded
their
outreach
efforts,
existence
established
relationships,
ways
individuals
consistently
prioritized
response
over
concerns
about
transmission
care
for
one
another.
Conclusions
findings
from
illustrate
complex
contextual
shape
highlight
importance
ensuring
needs
addressed
future
responses.
Harm Reduction Journal,
Journal Year:
2022,
Volume and Issue:
19(1)
Published: July 19, 2022
US
overdose
deaths
have
reached
a
record
high.
Syringe
services
programs
(SSPs)
play
critical
role
in
addressing
this
crisis
by
providing
multiple
to
people
who
use
drugs
(PWUD)
that
help
prevent
death.
This
study
examined
the
perspectives
of
leadership
and
staff
from
geographically
diverse
sample
SSPs
on
factors
contributing
surge,
their
organization's
response,
ongoing
barriers
preventing
Drug and Alcohol Review,
Journal Year:
2022,
Volume and Issue:
41(6), P. 1304 - 1310
Published: March 9, 2022
Abstract
Introduction
The
wide‐spread
implementation
of
interventions
to
limit
transmission
and
public
health
consequences
COVID‐19
in
the
Australian
state
Victoria
had
flow‐on
for
people
who
use
inject
drugs.
Consequences
included
interruption
illicit
drug
supply
procurement,
disruption
delivery
services.
To
inform
strategies
that
can
minimise
adverse
outcomes
similar
future
disruptive
events,
this
study
explored
how
restrictions
impacted
access
harm
reduction
treatment
services
drugs
Melbourne,
Victoria.
Methods
Qualitative
semi‐structured
interviews
were
conducted
via
an
online
calling
app,
with
11
participants
a
broader
cohort
(the
SuperMIX
study)
April
2020.
Interviews
focused
on
experiences
accessing
using
Data
thematically
analysed
process
blended
coding.
Results
Findings
revealed
disruptions
services—in
response
restrictions—created
barriers
sterile
injecting
equipment,
increased
risk
arrest
by
police
exacerbated
social
isolation.
Participants
reported
difficulties
adapting
changes
access,
some
increases
behaviours.
However,
improvements
opioid
agonist
therapy
prescriptions
noted
as
beneficial
outcome.
Discussion
By
examining
impacts
resultant
drugs'
Victoria,
findings
provide
guidance
responses
unanticipated
large‐scale
effects
pandemic,
events.
Journal of Public Health,
Journal Year:
2022,
Volume and Issue:
45(2), P. e215 - e224
Published: Oct. 29, 2022
In
2021,
during
a
drug-related
death
crisis
in
the
UK,
Government
published
its
ten-year
drugs
strategy.
This
article,
written
collaboration
with
Faculty
of
Public
Health
and
Association
Directors
Health,
assesses
whether
this
Strategy
is
evidence-based
consistent
international
calls
to
promote
public
health
approaches
drugs,
which
put
'people,
human
rights
at
centre'.
Elements
are
welcome,
including
promise
significant
funding
for
drug
treatment
services,
effects
will
depend
on
how
it
utilized
by
services
local
commissioners
sustained.
However,
unevidenced
harmful
measures
deter
use
means
punishment
continue
be
promoted,
have
deleterious
impacts
people
who
drugs.
An
effective
approach
should
tackle
population-level
risk
factors,
may
predispose
patterns
use,
adverse
childhood
experiences
socioeconomic
deprivation,
institute
mitigate
harm.
would
likely
more
effective,
just,
than
continuation
policies
rooted
enforcement.
A
dramatic
re-orientation
UK
policy
that
offered
overdue.