Cerebral blood flow in the paracentral lobule is associated with poor subjective sleep quality among patients with a history of methadone maintenance treatment DOI Creative Commons

Jiaxue Sun,

Yi Lü,

Deshenyue Kong

et al.

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 8, 2024

Introduction Sleep disorders are prevalent and significant among individuals receiving methadone maintenance treatment (MMT), adversely affecting their quality of life adherence. While cerebral blood flow (CBF) plays a crucial role in the development various diseases, its relationship with sleep remains uncertain. This observational study focuses on possible correlations between CBF poor subjective MMT patients. Methods A total 75 participants history were recruited assessed using pseudo-continuous arterial spin labeling magnetic resonance imaging to determine CBF. LAASO regression model was employed identify region interest (ROI) most associated disturbance. The association ROI Pittsburgh Quality Index (PSQI) examined analyses. Age, gender, BMI, hypertension, diabetes, hyperlipidemia, withdrawal included as covariates. Results Among patients quality, significantly higher observed right paracentral lobule (56.1057 ± 11.1624 ml/100 g/min, p = 0.044), cerebelum_3 (56.6723 15.3139 0.026), caudate nucleus (48.9168 6.9910 0.009), left (47.6207 6.1374 0.006). Furthermore, positive correlation found PSQI score (β 0.1135, 0.0323), remaining even after adjustment for covariates 0.1276, 0.0405). Conclusion exhibited altered multiple brain regions. increased could be understanding undergoing MMT. Clinical trial registration https://www.chictr.org.cn/ , identifier: ChiCTR2100051931.

Language: Английский

Cerebral blood flow in the paracentral lobule is associated with poor subjective sleep quality among patients with a history of methadone maintenance treatment DOI Creative Commons

Jiaxue Sun,

Yi Lü,

Deshenyue Kong

et al.

Frontiers in Neurology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 8, 2024

Introduction Sleep disorders are prevalent and significant among individuals receiving methadone maintenance treatment (MMT), adversely affecting their quality of life adherence. While cerebral blood flow (CBF) plays a crucial role in the development various diseases, its relationship with sleep remains uncertain. This observational study focuses on possible correlations between CBF poor subjective MMT patients. Methods A total 75 participants history were recruited assessed using pseudo-continuous arterial spin labeling magnetic resonance imaging to determine CBF. LAASO regression model was employed identify region interest (ROI) most associated disturbance. The association ROI Pittsburgh Quality Index (PSQI) examined analyses. Age, gender, BMI, hypertension, diabetes, hyperlipidemia, withdrawal included as covariates. Results Among patients quality, significantly higher observed right paracentral lobule (56.1057 ± 11.1624 ml/100 g/min, p = 0.044), cerebelum_3 (56.6723 15.3139 0.026), caudate nucleus (48.9168 6.9910 0.009), left (47.6207 6.1374 0.006). Furthermore, positive correlation found PSQI score (β 0.1135, 0.0323), remaining even after adjustment for covariates 0.1276, 0.0405). Conclusion exhibited altered multiple brain regions. increased could be understanding undergoing MMT. Clinical trial registration https://www.chictr.org.cn/ , identifier: ChiCTR2100051931.

Language: Английский

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