Viruses, Journal Year: 2024, Volume and Issue: 16(9), P. 1416 - 1416
Published: Sept. 5, 2024
Hepatitis C virus (HCV) infection and hazardous alcohol use are both preventable causes of morbidity mortality among people who inject drugs (PWID). In the general population, is associated with a reduced likelihood HCV treatment initiation. Less known about prevalence impact on direct-acting antiviral (DAA) therapy initiation PWID active injection drug use.
Language: Английский
Harm Reduction Journal, Journal Year: 2025, Volume and Issue: 22(1)
Published: March 5, 2025
People who use drugs (PWUD) are at increased mortality risk, yet they typically avoid healthcare settings due to stigma and shunning. Understanding the journey from viewpoint of PWUD has been understudied, although it is essential for informing solutions increase access improve their outcomes. We aimed understand process accessing PWUD, including perceived barriers facilitators, by exploring experiences, attitudes, beliefs. employed purposive sampling recruit participate in nine focus group discussions (FGDs) (N = 57) Athens, Greece. Inclusion criteria required a history injection drug use, internet access, Greek verbal fluency. The FGDs were audio-recorded, transcribed, translated into English, de-identified. analyzed FGD transcripts using modified grounded theory. Participants' mean (standard deviation) age was 47.9 (8.9) years, 89.5% (51/57) male, 91.2% (52/57) origin, 61.4% (35/57) had attended least 10 years school. identified three key themes transcript analysis: (1) seeking care after an individual's rapid health decline, (2) facing healthcare, (3) building trust PWUD. Participants disclosed that tended seek deterioration health. They experienced multiple such as stigma, system mistrust, unresponsive emergency medical services competing priorities homelessness, mental challenges, ongoing manifestations substance disorder (SUD). recommendations build patient-provider include minimization, promotion empathy relationship, engaging community organizations serve bridges with providers institutions. Greece demonstrate delayed health-seeking behaviors report multifaceted delays care, poor health, SUD manifestations. Key trust-building processes expand minimizing promoting encounters, enhancing staff education on SUD, improving responsiveness services, organizations, telehealth's role
Language: Английский
Citations
0
BMC Health Services Research, Journal Year: 2025, Volume and Issue: 25(1)
Published: April 10, 2025
Language: Английский
Citations
0
BMC Medical Informatics and Decision Making, Journal Year: 2024, Volume and Issue: 24(1)
Published: Oct. 19, 2024
People who use drugs (PWUD) often face restricted healthcare access despite their heightened needs. Factors such as stigma, mistrust of the system, competing priorities, and geographical barriers pose significant challenges. Telehealth offers an innovative solution to expand for better inclusion underserved populations in healthcare. We aimed explore PWUDs' perceptions telehealth a delivery modality. utilized purposive sampling recruit participants (N = 57) nine focus group discussions (FGDs) Athens, Greece. Eligibility criteria required be at least 18 years, with current or prior injection drug use, internet access. The FGDs followed semi-structured interview guide, were audio recorded, transcribed verbatim, translated into English, de-identified. applied thematic analysis analyze FGD transcripts. Participants' mean (standard deviation) age was 47.9 (8.9) 89.5% (51/57) male, 91.2% (52/57) Greek origin, 61.4% (35/57) had attended 10 years school. Three main themes emerged from FGDs: (1) high utilization healthcare-related purposes among PWUD, (2) highlighting benefits obstacles concerns about diagnostic accuracy, (3) approaches overcome build digital trust. Participants extensively used processes, accessing information scheduling provider appointments. Despite being telehealth-inexperienced, most expressed strong willingness embrace due its perceived convenience, time-saving nature, trusted environment. Some recognized that inability conduct physical examinations through reduces while others literacy technological infrastructure accessibility. Most preference video-based encounters over audio-only encounters. To trust promote patient-centeredness, recommended initial in-person visit, virtual eye contact during encounters, patient education, partnerships PWUD-supportive community organizations equipped appropriate infrastructure. PWUD frequently health-related suggested several enhance Their insights suggestions are practical guidance policymakers seeking telehealth. NCT05794984.
Language: Английский
Citations
3
Viruses, Journal Year: 2024, Volume and Issue: 16(6), P. 885 - 885
Published: May 30, 2024
People living with HIV-HCV co-infection comprise a target group for HCV-micro-elimination. We conducted an HCV cascade of care (CoC) co-infected individuals in Greece and investigated factors associated different HCV-CoC stages. analyzed data from 1213 participants the Athens Multicenter AIDS Cohort Study. A seven-stage CoC, overall by subgroup (people who inject drugs (PWID), men having sex (MSM), women (MSW), migrants], was constructed, spanning diagnosis to sustained virologic response (SVR). Logistic/Cox regression models were employed identify passing through each CoC step. Among anti-HCV-positive individuals, 9.2% died before direct-acting antiviral (DAA) availability. PWID exhibited higher mortality rates than MSM. Of 1101 survivors, 72.2% remained underwent HCV-RNA testing. Migrants showed lowest retention rates. available 79.2% those care, 77.8% diagnosed chronic HCV. Subsequently, 71% initiated DAAs, very low CD4 counts (<100 cells/μL) exhibiting lower odds DAA initiation. SVR testing 203 85.7% achieving SVR. The did not differ across risk groups. In 2023, significant gaps between-group differences persisted among Greece.
Language: Английский
Citations
1
HIV Medicine, Journal Year: 2024, Volume and Issue: 25(10), P. 1135 - 1144
Published: June 20, 2024
Abstract Objectives HIV/hepatitis C virus (HCV) co‐infection among people who inject drugs (PWID) remains a global health problem. The goal of our study was to evaluate, in real‐world setting, success rates sustained virological response (SVR) using direct‐acting antivirals (DAAs) treat population PWID living with HCV/HIV. Methods This prospective single‐center observational study. We collected demographic, socioeconomic, and clinical data pertaining HIV HCV infection several barriers care. identified risk factors for SVR failure. Results Among 130 individuals retained care, we planned treatment 119/130 (91.5%); 106/119 (89.1%) started DAAs 100/106 (94.3%) completed treatment. People not starting were more often active opioid drug use (odds ratio [OR] 0.25; 95% confidence interval [CI] 0.07–0.97, p = 0.045) benzodiazepine abuse (OR CI 0.07–0.95, 0.042). Only 86/100 (86%) tested at 12 weeks (SVR12) 72/86 (83.7%) achieved SVR. substitution programmes tended return SVR12 testing (54.7% vs. 30%, 0.081). Individuals 0.226; 0.064–0.793, 0.02) or poor adherence 0.187; 0.043–0.814, 0.025) less likely achieve At the end period, 113/119 (95%) treatment‐eligible patients remained alive. cured 68/113 (61.1%) people. Conclusions Our findings underscore importance prioritizing combatting substance elimination goals. A systematic approach effort overcome receiving completing encourage enrol if possible completely abstain from use, can help increase chances cure.
Language: Английский
Citations
1
Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown
Published: June 26, 2024
Language: Английский
Citations
1
Substance Abuse and Rehabilitation, Journal Year: 2024, Volume and Issue: Volume 15, P. 173 - 183
Published: Sept. 1, 2024
A large treatment gap exists for people who could benefit from medications opioid use disorder (MOUD). People OUD accessing services in harm reduction and community-based organizations often have difficulty engaging MOUD at programs traditional health care settings. We conducted a study to test the impacts of first model six Washington (WA) State communities that provided drop-in access.
Language: Английский
Citations
1
HIV Medicine, Journal Year: 2024, Volume and Issue: unknown
Published: Nov. 18, 2024
Abstract Objectives Our aim was to examine mortality trends in the era of antiretroviral therapy, among people who inject drugs (PWID) are living with HIV. The study objectives were assess and quantify PWID diagnosed HIV over time Scotland, context a recent outbreak rise drug‐related mortality. Methods This retrospective cohort those Scotland between January 2000 February 2020, acquisition related injecting drug use, linked data. Factors associated all‐cause examined using Cox proportional hazards regression. Results Among 430 individuals 3143 person‐years (py) follow‐up, 88 (20.5%) died. Drug‐related deaths accounted for 45.5% all deaths, rising 60% 2015–2020. crude 28.00 per 1000 py overall 37.62 within 5 years diagnosis. Mortality risk markedly higher 2015–2020 [adjusted hazard ratio (aHR) = 3.53], relative 2000–2004. (as part outbreak), not on, compared opioid agonist therapy (aHR 3.87). Conclusion has risen substantially 21st century. findings highlight important role opioid‐agonist alongside other prevention treatment measures address high levels HIV, including outbreaks this population group.
Language: Английский
Citations
1
Viruses, Journal Year: 2024, Volume and Issue: 16(9), P. 1416 - 1416
Published: Sept. 5, 2024
Hepatitis C virus (HCV) infection and hazardous alcohol use are both preventable causes of morbidity mortality among people who inject drugs (PWID). In the general population, is associated with a reduced likelihood HCV treatment initiation. Less known about prevalence impact on direct-acting antiviral (DAA) therapy initiation PWID active injection drug use.
Language: Английский
Citations
0