Drug Resistance Updates,
Journal Year:
2024,
Volume and Issue:
76, P. 101116 - 101116
Published: July 3, 2024
Drug
resistance
and
tumor
recurrence
remain
clinical
challenges
in
the
treatment
of
urothelial
carcinoma
(UC).
However,
underlying
mechanism
is
not
fully
understood.
Here,
we
performed
single-cell
RNA
sequencing
identified
a
subset
cells
with
epithelial-mesenchymal
transition
(EMT)
features
(EMT-UC),
which
significantly
correlated
chemotherapy
cancer
recurrence.
To
validate
significance
EMT-UC,
constructed
EMT-UC
like
by
introducing
overexpression
two
markers,
Zinc
Finger
E-Box
Binding
Homeobox
1
(ZEB1)
Desmin
(DES),
examined
their
histological
distribution
characteristics
malignant
phenotypes.
were
mainly
enriched
UC
tissues
from
patients
adverse
prognosis
exhibited
elevated
EMT,
migration
gemcitabine
tolerance
vitro.
was
specifically
tumorous
tissues,
certain
proportion
them
also
adjacent
normal
tissues.
Tumorous
highly
expressed
genes
involved
behaviors
prognosis.
Additionally,
associated
remodeled
microenvironment
(TME),
high
angiogenic
immunosuppressive
potentials
compared
counterparts.
Furthermore,
specific
interaction
COL4A1
ITGB1
to
be
endothelial
component.
Targeting
antibodies
suppressed
angiogenesis
alleviated
UC.
Overall,
our
findings
demonstrated
that
driven
force
mediated
COL4A1-ITGB1
interaction,
providing
potential
target
for
future
treatment.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: March 8, 2024
Ferroptosis
is
a
non-apoptotic
form
of
regulated
cell
death
characterized
by
the
lethal
accumulation
iron-dependent
membrane-localized
lipid
peroxides.
It
acts
as
an
innate
tumor
suppressor
mechanism
and
participates
in
biological
processes
tumors.
Intriguingly,
mesenchymal
dedifferentiated
cancer
cells,
which
are
usually
resistant
to
apoptosis
traditional
therapies,
exquisitely
vulnerable
ferroptosis,
further
underscoring
its
potential
treatment
approach
for
cancers,
especially
refractory
cancers.
However,
impact
ferroptosis
on
extends
beyond
direct
cytotoxic
effect
cells.
induction
not
only
inhibits
but
also
promotes
development
due
negative
anticancer
immunity.
Thus,
comprehensive
understanding
role
crucial
successful
translation
therapy
from
laboratory
clinical
applications.
In
this
review,
we
provide
overview
recent
advancements
cancer,
covering
molecular
mechanisms,
functions,
regulatory
pathways,
interactions
with
microenvironment.
We
summarize
applications
immunotherapy,
radiotherapy,
systemic
therapy,
well
inhibition
various
conditions.
finally
discuss
markers,
current
challenges
future
directions
cancer.
Molecular Biomedicine,
Journal Year:
2023,
Volume and Issue:
4(1)
Published: Oct. 16, 2023
Abstract
Ferroptosis,
a
regulated
form
of
cellular
death
characterized
by
the
iron-mediated
accumulation
lipid
peroxides,
provides
novel
avenue
for
delving
into
intersection
metabolism,
oxidative
stress,
and
disease
pathology.
We
have
witnessed
mounting
fascination
with
ferroptosis,
attributed
to
its
pivotal
roles
across
diverse
physiological
pathological
conditions
including
developmental
processes,
metabolic
dynamics,
oncogenic
pathways,
neurodegenerative
cascades,
traumatic
tissue
injuries.
By
unraveling
intricate
underpinnings
molecular
machinery,
contributors,
signaling
conduits,
regulatory
networks
governing
researchers
aim
bridge
gap
between
intricacies
this
unique
mode
multifaceted
implications
health
disease.
In
light
rapidly
advancing
landscape
ferroptosis
research,
we
present
comprehensive
review
aiming
at
extensive
in
origins
progress
human
diseases.
This
concludes
careful
analysis
potential
treatment
approaches
carefully
designed
either
inhibit
or
promote
ferroptosis.
Additionally,
succinctly
summarized
therapeutic
targets
compounds
that
hold
promise
targeting
within
various
facet
underscores
burgeoning
possibilities
manipulating
as
strategy.
summary,
enriched
insights
both
investigators
practitioners,
while
fostering
an
elevated
comprehension
latent
translational
utilities.
revealing
basic
processes
investigating
possibilities,
crucial
resource
scientists
medical
aiding
deep
understanding
effects
situations.
Signal Transduction and Targeted Therapy,
Journal Year:
2024,
Volume and Issue:
9(1)
Published: Oct. 14, 2024
Iron,
an
essential
mineral
in
the
body,
is
involved
numerous
physiological
processes,
making
maintenance
of
iron
homeostasis
crucial
for
overall
health.
Both
overload
and
deficiency
can
cause
various
disorders
human
diseases.
Ferroptosis,
a
form
cell
death
dependent
on
iron,
characterized
by
extensive
peroxidation
lipids.
Unlike
other
kinds
classical
unprogrammed
death,
ferroptosis
primarily
linked
to
disruptions
metabolism,
lipid
peroxidation,
antioxidant
system
imbalance.
Ferroptosis
regulated
through
transcription,
translation,
post-translational
modifications,
which
affect
cellular
sensitivity
ferroptosis.
Over
past
decade
or
so,
diseases
have
been
as
part
their
etiology,
including
cancers,
metabolic
disorders,
autoimmune
diseases,
central
nervous
cardiovascular
musculoskeletal
Ferroptosis-related
proteins
become
attractive
targets
many
major
that
are
currently
incurable,
some
regulators
shown
therapeutic
effects
clinical
trials
although
further
validation
potential
needed.
Therefore,
in-depth
analysis
its
molecular
mechanisms
may
offer
additional
strategies
prevention
treatment.
In
this
review,
we
discuss
significance
contribution
etiology
development
along
with
evidence
supporting
targeting
approach.
Importantly,
evaluate
recent
promising
interventions,
providing
guidance
future
targeted
treatment
therapies
against
Cell Death Discovery,
Journal Year:
2024,
Volume and Issue:
10(1)
Published: April 22, 2024
Abstract
Cancer-associated
fibroblasts
(CAFs),
the
main
stromal
component
of
tumor
microenvironment
(TME),
play
multifaceted
roles
in
cancer
progression
through
paracrine
signaling,
exosome
transfer,
and
cell
interactions.
Attractively,
recent
evidence
indicates
that
CAFs
can
modulate
various
forms
regulated
death
(RCD)
adjacent
cells,
thus
involving
proliferation,
therapy
resistance,
immune
exclusion.
Here,
we
present
a
brief
introduction
to
basic
knowledge
RCD,
including
apoptosis,
autophagy,
ferroptosis,
pyroptosis.
In
addition,
further
summarize
different
types
RCD
tumors
are
mediated
by
CAFs,
as
well
effects
these
modes
on
CAFs.
This
review
will
deepen
our
understanding
interactions
between
might
offer
novel
therapeutic
avenues
for
future
treatments.
Biology of the Cell,
Journal Year:
2025,
Volume and Issue:
117(1)
Published: Jan. 1, 2025
Ferroptosis
is
a
type
of
cell
death
that
multiple
mechanisms
and
pathways
contribute
to
the
positive
negative
regulation
it.
For
example,
increased
levels
reactive
oxygen
species
(ROS)
induce
ferroptosis.
ferroptosis
unlike
apoptosis,
it
not
dependent
on
caspases,
but
iron.
Exosomes
are
membrane-bound
vesicles
with
size
about
30
150
nm,
contain
various
cellular
components,
including
DNA,
RNA,
microRNAs
(miRNAs),
lipids,
proteins,
which
genetically
similar
their
cells
origin.
found
in
all
bodily
fluids,
blood,
saliva,
urine.
Cells
often
release
exosomes
after
fusion
membrane.
They
play
an
important
role
immune
cell-cell
communication.
miRNAs,
noncoding
RNAs
length
18
24
nucleotides,
involved
regulating
gene
expression
transcription.
Emerging
data
suggests
exosomal
miRNAs
implicated
pathophysiological
cells,
metastasis,
drug
resistance,
death.
In
addition,
functional
studies
have
indicated
can
key
modulation
by
Therefore,
this
review,
given
importance
ferroptosis,
we
decided
elucidate
relationship
between
diseases.
Biomedicine & Pharmacotherapy,
Journal Year:
2023,
Volume and Issue:
166, P. 115425 - 115425
Published: Sept. 4, 2023
Despite
continuous
improvements
in
research
and
new
cancer
therapeutics,
the
goal
of
eradicating
remains
elusive
because
drug
resistance.
For
a
long
time,
resistance
has
been
focused
on
tumor
cells
themselves;
however,
recent
studies
have
found
that
microenvironment
also
plays
an
important
role
inducing
Cancer-associated
fibroblasts
(CAFs)
are
main
component
microenvironment.
They
cross-talk
with
to
support
their
survival
presence
anticancer
drugs.
This
review
summarizes
current
knowledge
CAFs
An
in-depth
understanding
mechanisms
underlying
between
insight
into
importance
can
guide
development
strategies.
Molecular Cancer,
Journal Year:
2024,
Volume and Issue:
23(1)
Published: Aug. 27, 2024
Abstract
The
development
of
drug
resistance
remains
a
major
challenge
in
cancer
treatment.
Ferroptosis,
unique
type
regulated
cell
death,
plays
pivotal
role
inhibiting
tumour
growth,
presenting
new
opportunities
treating
chemotherapeutic
resistance.
Accumulating
studies
indicate
that
epigenetic
modifications
by
non-coding
RNAs
(ncRNA)
can
determine
vulnerability
to
ferroptosis.
In
this
review,
we
first
summarize
the
growth/development.
Then,
core
molecular
mechanisms
ferroptosis,
its
upstream
regulation,
and
downstream
effects
on
Finally,
review
recent
advances
understanding
how
ncRNAs
regulate
ferroptosis
from
such
modulate
This
aims
enhance
general
ncRNA-mediated
regulatory
which
highlighting
ncRNA-ferroptosis
axis
as
key
druggable
target
overcoming
