A story of two kingdoms: unravelling the intricacies of protein phase separation in plants and animals DOI Creative Commons
Min Li, Xue Yang, Di Zhang

et al.

Critical Reviews in Biotechnology, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 21

Published: Nov. 26, 2024

The biomolecular condensates (BCs) formed by proteins through phase separation provide the necessary space and raw materials for orderly progression of cellular activities, on this basis, various membraneless organelles (MLOs) are formed. occurrence eukaryotic is driven multivalent interactions from intrinsically disordered regions (IDRs) and/or specific protein/nucleic acid binding domains regulated environmental factors. In plant animal cells, MLOs involved in gene expression regulation, stress response, mitotic control display similar functions mechanisms. contrast, related to reproductive development immune regulation differs significantly between two kingdoms owing their distinct cell structures nutritional patterns. addition, animals plants each exhibit unique protein such as neural light signal response. By comparing similarities differences formation mechanism functional known separation, we elucidated its importance evolution, differentiation, adaptation both plants. significance studying enhancing biological quality life has been further emphasized.

Language: Английский

A comprehensive review of integrated management strategies for damping-off disease in chili DOI Creative Commons
Delai Chen, Ghulam Muhae-Ud-Din,

Rimsha Abid

et al.

Frontiers in Microbiology, Journal Year: 2024, Volume and Issue: 15

Published: Oct. 17, 2024

Damping-off disease in chili (

Language: Английский

Citations

6
Integrated Metabolomic and Transcriptomic Analysis Reveals the Pharmacological Effects and Differential Mechanisms of Isoflavone Biosynthesis in Four Species of Glycyrrhiza DOI Open Access
Yinhua Lü, Zhen Ding, Daoyuan Zhang

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2539 - 2539

Published: March 12, 2025

Licorice (Glycyrrhiza L.) is a globally popular medicinal and edible plant, with nearly 30 species distributed across all continents. The usable part primarily the root. To understand metabolic differences among different Glycyrrhiza species, we selected four performed comprehensive analyses of their roots. Metabolomic profiling was conducted using UPLC-MS/MS GC-MS, while transcriptomic analysis carried out RNA-sequencing. A total 2716 metabolites were identified, including flavonoids (527 types) terpenoids (251 types), various other components. Subsequently, network pharmacology employed to explore value potential pharmacological ingredients these metabolites. Joint metabolomic data revealed significant in differentially accumulated (DAMs) expressed genes (DEGs) pairwise comparisons species. These enriched isoflavone pathway. Further investigation into regulatory mechanisms biosynthesis identified key involved biosynthesis. Finally, made reasonable predictions suitable habitats for aiming provide new insights development utilization licorice resources. results this study can serve as basis in-depth research on regulation licorice.

Language: Английский

Citations

0
Deciphering the Complex Roles of Leucine-Rich Repeat Receptor Kinases (LRR-RKs) in Plant Signal Transduction DOI
Ting Tang, Ferdinand Ndikuryayo,

Xueyan Gong

et al.

Plant Science, Journal Year: 2025, Volume and Issue: unknown, P. 112494 - 112494

Published: April 1, 2025

Language: Английский

Citations

0
Unraveling the Intricacies of Powdery Mildew: Insights into Colonization, Plant Defense Mechanisms, and Future Strategies DOI Open Access

Chunmei Gan,

Ting Tang, Ziyu Zhang

et al.

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(8), P. 3513 - 3513

Published: April 9, 2025

Powdery mildew, a debilitating phytopathogen caused by biotrophic fungi within the order Erysiphales, endangers crop yields and global food security. Although traditional approaches have largely emphasized resistant cultivar development chemical control, novel strategies are necessary to counter advent of challenges, such as pathogen adaptation climate change. This review fully discusses three principal areas effector functions, e.g., reactive oxygen species (ROS)-suppressive activity CSEP087, host susceptibility factors, like vesicle trafficking regulated Mildew Locus O (MLO). It also briefly mentions transcriptional regulation resistance genes mediated WRKY75 NAC transcription post-transcriptional via alternative splicing (As). In addition, this discussion intricate interactions among powdery plants, symbiotic microbiomes thereof, highlighting mechanism through which mildew infections disrupt foliar microbiota balance. Lastly, we present new biocontrol approach that entails synergistic microbial consortia, combinations Bacillus Trichoderma, induce plant immunity while minimizing fungicide dependency. Through study combining knowledge molecular pathogenesis with ecological resilience, research offers useful insights towards climate-smart sustainable disease-management in context microbiome engineering.

Language: Английский

Citations

0
Sustainable nano-therapeutic approaches using bio-based vanillic acid nanocomposites to enhance salinity tolerance and essential oil quality in Satureja hortensis DOI Creative Commons

Azar Parvaneh,

Seyed Mehdi Razavi, Maryam Khoshkam

et al.

Industrial Crops and Products, Journal Year: 2025, Volume and Issue: 229, P. 121016 - 121016

Published: April 16, 2025

Language: Английский

Citations

0
Sesquiterpenoids in Agarwood: Biosynthesis, Microbial Induction, and Pharmacological Activities DOI
Xinghao Zhang,

Lan Xiang Wang,

Ruirui Hao

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(42), P. 23039 - 23052

Published: Oct. 8, 2024

Agarwood, derived from the Aquilaria genus, is widely utilized in perfumery, traditional medicine, and cultural practices throughout Asia. Agarwood rich terpenes, especially sesquiterpenes, which are considered to be source of its rare exquisite fragrance. This Review consolidates recent research on sesquiterpene biosynthesis agarwood influence fungi these processes, alongside a discussion potential medicinal value sesquiterpenes. commences by elucidating general sesquiterpenes identifying main enzymes transcription factors involved production also summarizes associated with highlights how commensal stimulate production. We then scrutinize pharmacological properties underscoring their anti-inflammatory antimicrobial effects, closely linked cellular signaling pathways, such as NF-κB MAPK pathways. Additionally, we review therapeutic benefits essential oil for antidepressant properties, regulation stress-related neurochemical hormonal addresses challenges sustainable production, highlighting issues overharvesting habitat loss while discussing strategy harnessing microbes support ecological preservation wild resources. By advancing our knowledge characteristics, propose directions future application development research.

Language: Английский

Citations

3
Computer-aided pattern scoring (C@PS): a novel cheminformatic workflow to predict ligands with rare modes-of-action DOI Creative Commons
Sven Marcel Stefan, Sven Marcel Stefan, Vigneshwaran Namasivayam

et al.

Journal of Cheminformatics, Journal Year: 2024, Volume and Issue: 16(1)

Published: Sept. 23, 2024

The identification, establishment, and exploration of potential pharmacological drug targets are major steps the development pipeline. Target validation requires diverse chemical tools that come with a spectrum functionality, e.g., inhibitors, activators, other modulators. Particularly rare modes-of-action allow for proper kinetic functional characterization targets-of-interest (e.g., channels, enzymes, receptors, or transporters). Despite, innovation is prime criterion patentability commercial exploitation, which may lead to therapeutic benefit. Unfortunately, data on new, thus, undruggable barely druggable scarce mostly available mainstream only inhibition). Here we present novel cheminformatic workflow-computer-aided pattern scoring (C@PS)-which was specifically designed project its prediction capabilities into an uncharted domain applicability.

Language: Английский

Citations

2
Role and mechanism of the outer membrane porin LamB in T-2 mycotoxin-mediated extensive drug resistance in Escherichia coli DOI

Fengru Deng,

Li Zhao, Ping Wei

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 480, P. 136437 - 136437

Published: Nov. 6, 2024

Language: Английский

Citations

0
Mechanisms of calcium-induced protection against lead toxicity in Ulmus umbraculifera L.: a physiological and biochemical perspective DOI
Giti Barzin,

Zoya Janebelahi Firozabadi,

Roya Bishehkolaei

et al.

Ecotoxicology, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 6, 2024

Language: Английский

Citations

0
A story of two kingdoms: unravelling the intricacies of protein phase separation in plants and animals DOI Creative Commons
Min Li, Xue Yang, Di Zhang

et al.

Critical Reviews in Biotechnology, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 21

Published: Nov. 26, 2024

The biomolecular condensates (BCs) formed by proteins through phase separation provide the necessary space and raw materials for orderly progression of cellular activities, on this basis, various membraneless organelles (MLOs) are formed. occurrence eukaryotic is driven multivalent interactions from intrinsically disordered regions (IDRs) and/or specific protein/nucleic acid binding domains regulated environmental factors. In plant animal cells, MLOs involved in gene expression regulation, stress response, mitotic control display similar functions mechanisms. contrast, related to reproductive development immune regulation differs significantly between two kingdoms owing their distinct cell structures nutritional patterns. addition, animals plants each exhibit unique protein such as neural light signal response. By comparing similarities differences formation mechanism functional known separation, we elucidated its importance evolution, differentiation, adaptation both plants. significance studying enhancing biological quality life has been further emphasized.

Language: Английский

Citations

0