Nutrition Metabolism and Cardiovascular Diseases, Journal Year: 2024, Volume and Issue: unknown, P. 103798 - 103798
Published: Nov. 1, 2024
Language: Английский
Diabetes Obesity and Metabolism, Journal Year: 2025, Volume and Issue: unknown
Published: March 7, 2025
The association between lifestyle and metabolic dysfunction-associated steatotic liver disease (MASLD) has been well documented. However, evidence is still limited from vulnerable populations, especially middle-aged elderly adults with comorbid hypertension diabetes, who are at higher risk of developing MASLD than the general population. We aimed to examine potential causal links a healthy in this A total 41,964 participants diabetes were included longitudinal cohort 2010 2023. Weighted scores for evaluated by exercise frequency, alcohol consumption, smoking status salt intake. Marginal structural models used estimate single lifestyle-MASLD associations, which further stratified quartile ranges weighted scores. mean follow-up period 5.2 years (217 972 person-years) revealed that 21 697 developed MASLD. hazard ratio (HR) daily exercise, never consuming alcohol, low intake was 0.617 (95% confidence interval: 0.365 ~ 1.042), 0.237 (0.093 0.603), 0.153 (0.097 0.240) 0.945 (0.919 0.971), respectively. Compared below 25th percentile, HR 0.952 (0.902 1.005), 0.747 (0.694 0.803) 0.097 (0.065 0.144) 25th, 50th 75th percentiles, In population, abstinence low-salt diet may reduce MASLD, most stringent combination lifestyles could over 90%.
Language: Английский
Citations
0
Acta Diabetologica, Journal Year: 2025, Volume and Issue: unknown
Published: April 1, 2025
Language: Английский
Citations
0
Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)
Published: April 18, 2025
Abstract Metabolic (dysfunction) associated fatty liver disease (MAFLD) is a growing global concern. This study assessed the frequency of hepatic steatosis and MAFLD, alongside their risk factors, among medical students at Suez University, Egypt. A cross-sectional was conducted from November 2022 to April 2023 84 aged ≥ 18 years. Data on anthropometric parameters, body composition, lifestyle were collected through self-administered questionnaires, InBody analysis, FibroScan. MAFLD diagnosis required (≥ 238 dB/m) with obesity, metabolic dysfunction, or both. Statistical analyses included chi-square tests, ANOVA, logistic regression. Hepatic present in 25% participants, while 13.1%. Participants exhibited higher weight (82.34 ± 10.78 kg vs. 65.84 10.61 kg, p < 0.001), BMI (29.05 3.66 22.90 3.23 kg/m 2 , waist circumference (88.73 8.73 cm 78.10 7.96 cm, BMR (1566.09 27.37 1429.86 93.44 kcal/day, fat mass (32.74 7.25% 23.91 8.60%, 0.001). Binary regression analysis revealed increased weight, BMI, circumference, as significant factors for MAFLD. An elevated percentage reduced muscle highlighted sarcopenic obesity role progression. Extreme reduction can exacerbate accumulation. Poor sleep quality, sedentary lifestyle, an unhealthy diet are also predictors. The widespread highlights pressing need tackle this silent epidemic young Egyptian adults.
Language: Английский
Citations
0
Journal of Nutrition Education and Behavior, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 1, 2025
Language: Английский
Citations
0
Annals of Medicine, Journal Year: 2025, Volume and Issue: 57(1)
Published: April 6, 2025
Liver steatosis and fibrosis increase the predicted 10-year atherosclerotic cardiovascular disease (ASCVD) risk, though roles of chronic inflammation metabolic dysregulation remain unclear. This cross-sectional study quantitatively assesses this association evaluates mediating effects inflammation. In study, we enrolled 6110 adults from ten communities in Canton, China. Hepatic were assessed using vibration-controlled transient elastography (VCTE) through controlled attenuation parameter (CAP) liver stiffness measurement (LSM), while ASCVD risk was calculated China-PAR project model. Associations between CAP/LSM values analyzed. Mediation analysis quantified high-sensitivity C-reactive protein (hs-CRP), homeostasis model assessment insulin resistance (HOMA-IR), remnant cholesterol (RC), non-high-density lipoprotein (non-HDL-C). The main statistical methods used included logistic regression, restricted cubic splines (RCS) analysis, interaction calculations, mediation to examine relationships mediators. population had a mean age 50.1 years (SD = 9.7), with 3927 females (64.3%) 2183 males (35.7%). Additionally, 808 participants (13.2%) type 2 diabetes, 1911 (31.3%) hypertension. Compared first CAP quartile (Q1), higher quartiles showed increased odds ratios (OR) for moderate high risk: 1.14 (0.89, 1.45), 1.37 (1.08, 1.73), 2.44 (1.93, 3.10). hs-CRP HOMA-IR mediated CAP's link proportions 15.40% 27.37%. RC non-HDL-C at 7.12% 6.26%. Among patients hepatic (CAP ≥ 248 dB/m), LSM Q4 significantly than those Q1 (OR 2.22, [1.52, 3.25]), 2.62% 13.75%, respectively. associated hs-CRP, HOMA-IR, RC, non-HDL-C.
Language: Английский
Citations
0
Journal of Diabetes Investigation, Journal Year: 2025, Volume and Issue: unknown
Published: May 2, 2025
ABSTRACT Controlling the epidemic of diabetes is an urgent global healthcare challenge. The low uptake prevention programs highlights difficulties in scalability, partly due to need for intensive face‐to‐face contact and its impact on resource utilization. In this narrative review, we will summarize latest evidence technology‐assisted lifestyle interventions. We appraise digital that use internet platforms or text messaging tools support information delivery, coaching, peer support. also discuss wearables, including physical activity trackers continuous glucose monitoring (CGM) as part intervention. Experience from potential CGM a motivational tool promote change. integration data may facilitate earlier detection prediabetes, sub‐phenotyping, personalized nutritional predictions. highlight major gaps research rigorous clinical trials evaluate acceptability cost‐effectiveness integrating technologies multicomponent strategy prevention.
Language: Английский
Citations
0
Nutrition & Metabolism, Journal Year: 2024, Volume and Issue: 21(1)
Published: July 9, 2024
Abstract Background Although several studies have found the relationship between essential elements and diabetes, about association of with diabetes diagnosed according to an oral glucose tolerance test (OGTT) glycated hemoglobin (HbA1c) in a sex- age-specific manner were limited. To investigate linear nonlinear five including iron (Fe), copper (Cu), Zinc (Zn), magnesium (Mg), calcium (Ca) fasting plasma (FPG), 2-h postprandial (PPG), HbA1c evaluate heterogeneities these relationships. Methods A total 8392 community-dwelling adults recruited complete questionnaire undergo checkups anthropometric parameters serum levels metals (Fe, Cu, Zn, Mg, Ca). The multivariable logistic regression, restricted cubic spline (RCS) analysis, subgroup analysis applied find associations prevalence as well FPG, PPG, HbA1c. Results In regression Cu was positively associated while Mg significantly inversely correlated HbA1c, (all P < 0.001). RCS non-linear ( 0.001) found. stronger positive for interaction = 0.027) PPG 0.002) younger women. Conclusions These findings may lead more appropriate approaches supplementation people different ages sexes. However, prospective cohort experimental are needed probe possible mechanism diabetes.
Language: Английский
Citations
3
Annals of Medicine, Journal Year: 2024, Volume and Issue: 56(1)
Published: Aug. 12, 2024
The association of appendicular skeletal muscle mass (ASM), grip strength and fat-to-muscle ratio (FMR) the progression metabolic dysfunction-associated steatotic liver disease (MASLD) are not well known.
Language: Английский
Citations
1
Diabetes & Metabolic Syndrome Clinical Research & Reviews, Journal Year: 2024, Volume and Issue: 18(3), P. 103009 - 103009
Published: March 1, 2024
Language: Английский
Citations
0
Nutrition Metabolism and Cardiovascular Diseases, Journal Year: 2024, Volume and Issue: unknown, P. 103798 - 103798
Published: Nov. 1, 2024
Language: Английский
Citations
0