OMICS A Journal of Integrative Biology,
Journal Year:
2023,
Volume and Issue:
27(12), P. 550 - 569
Published: Dec. 1, 2023
With
climate
emergency,
COVID-19,
and
the
rise
of
planetary
health
scholarship,
binary
human
ecosystem
has
been
deeply
challenged.
The
interdependence
nonhuman
animal
is
increasingly
acknowledged
paving
way
for
new
frontiers
in
integrative
biology.
convergence
genomics
health,
bioinformatics,
agriculture,
artificial
intelligence
(AI)
ushered
a
era
possibilities
applications.
However,
sheer
volume
genomic/multiomics
big
data
generated
also
presents
formidable
sociotechnical
challenges
extracting
meaningful
biological,
ecological
insights.
Over
past
few
years,
AI-guided
bioinformatics
emerged
as
powerful
tool
managing,
analyzing,
interpreting
complex
biological
datasets.
advances
AI,
particularly
machine
learning
deep
learning,
have
transforming
fields
genomics,
agriculture.
This
article
aims
to
unpack
explore
range
that
result
from
such
transdisciplinary
integration,
emphasizes
its
radically
transformative
potential
health.
integration
these
disciplines
driving
significant
advancements
precision
medicine
personalized
care.
an
unprecedented
opportunity
deepen
our
understanding
systems
advance
well-being
all
life
ecosystems.
Notwithstanding
mind
sociotechnical,
ethical,
critical
policy
challenges,
multiomics,
agriculture
with
opens
up
vast
opportunities
transnational
collaborative
efforts,
sharing,
analysis,
valorization,
interdisciplinary
innovations
sciences
Cold Spring Harbor Perspectives in Medicine,
Journal Year:
2023,
Volume and Issue:
13(11), P. a041337 - a041337
Published: Aug. 21, 2023
Naoko
Sasamoto1
and
Kevin
M.
Elias2
1Obstetrics
Gynecology
Epidemiology
Center,
Department
of
Obstetrics
Gynecology,
Brigham
Women's
Hospital
Harvard
Medical
School,
Boston,
Massachusetts
02115,
USA
2Division
Gynecologic
Oncology,
Hospital,
Dana-Farber
Cancer
Institute,
Correspondence:
kelias{at}bwh.harvard.edu
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(2), P. 1604 - 1604
Published: Jan. 13, 2023
Skin
cancer,
including
malignant
melanoma
(MM)
and
keratinocyte
carcinoma
(KC),
historically
named
non-melanoma
skin
cancers
(NMSC),
represents
the
most
common
type
of
cancer
among
white
population.
Despite
decades
clinical
research,
incidence
rate
is
increasing
globally.
Therefore,
a
better
understanding
disease
pathogenesis
resistance
mechanisms
considered
vital
to
accomplish
early
diagnosis
satisfactory
control.
The
“Omics”
field
has
recently
gained
attention,
as
it
can
help
in
identifying
exploring
metabolites
metabolic
pathways
that
assist
cells
proliferation,
which
be
further
utilized
improve
treatment
cancer.
Although
tissues
contain
diverse
enzymes,
remains
challenging
fully
characterize
these
metabolites.
Metabolomics
powerful
omics
technique
allows
us
measure
compare
vast
array
biological
sample.
This
technology
enables
study
dermal
effects
get
clear
explanation
diseases.
purpose
this
literature
review
illustrate
how
metabolomics
used
evaluate
profile
human
using
variety
analytical
platforms
gas
chromatography-mass
spectrometry
(GC-MS),
liquid
(LC-MS),
nuclear
magnetic
resonance
(NMR).
Data
collection
not
been
based
on
any
method.
Cell Death and Disease,
Journal Year:
2023,
Volume and Issue:
14(8)
Published: Aug. 23, 2023
KIAA1324
is
a
transmembrane
protein
largely
reported
as
tumor
suppressor
and
favorable
prognosis
marker
in
various
cancers,
including
gastric
cancer.
In
this
study,
we
report
the
role
of
N-linked
glycosylation
functional
post-translational
modification
(PTM).
Loss
eliminated
potential
to
suppress
cancer
cell
proliferation
migration.
Furthermore,
demonstrated
that
undergoes
fucosylation,
N-glycan
mediated
by
fucosyltransferase,
inhibition
fucosylation
also
significantly
suppressed
KIAA1324-induced
growth
apoptosis
cells.
addition,
KIAA1324-mediated
regression
were
inhibited
loss
glycosylation.
RNA
sequencing
(RNAseq)
analysis
revealed
genes
most
relevant
cycle
arrest
pathways
modulated
with
glycosylation,
Gene
Regulatory
Network
(GRN)
suggested
novel
targets
for
anti-tumor
effects
transcription
level.
The
blockade
decreased
stability
through
rapid
proteasomal
degradation.
non-glycosylated
mutant
showed
altered
localization
lost
apoptotic
activity
inhibits
interaction
between
GRP78
caspase
7.
These
data
demonstrate
essential
suppressive
progression
indicates
may
have
targeting
cancer-related
conclusion,
our
study
suggests
PTM
necessary
factor
consider
therapy
improvement.
OMICS A Journal of Integrative Biology,
Journal Year:
2023,
Volume and Issue:
27(12), P. 550 - 569
Published: Dec. 1, 2023
With
climate
emergency,
COVID-19,
and
the
rise
of
planetary
health
scholarship,
binary
human
ecosystem
has
been
deeply
challenged.
The
interdependence
nonhuman
animal
is
increasingly
acknowledged
paving
way
for
new
frontiers
in
integrative
biology.
convergence
genomics
health,
bioinformatics,
agriculture,
artificial
intelligence
(AI)
ushered
a
era
possibilities
applications.
However,
sheer
volume
genomic/multiomics
big
data
generated
also
presents
formidable
sociotechnical
challenges
extracting
meaningful
biological,
ecological
insights.
Over
past
few
years,
AI-guided
bioinformatics
emerged
as
powerful
tool
managing,
analyzing,
interpreting
complex
biological
datasets.
advances
AI,
particularly
machine
learning
deep
learning,
have
transforming
fields
genomics,
agriculture.
This
article
aims
to
unpack
explore
range
that
result
from
such
transdisciplinary
integration,
emphasizes
its
radically
transformative
potential
health.
integration
these
disciplines
driving
significant
advancements
precision
medicine
personalized
care.
an
unprecedented
opportunity
deepen
our
understanding
systems
advance
well-being
all
life
ecosystems.
Notwithstanding
mind
sociotechnical,
ethical,
critical
policy
challenges,
multiomics,
agriculture
with
opens
up
vast
opportunities
transnational
collaborative
efforts,
sharing,
analysis,
valorization,
interdisciplinary
innovations
sciences
