Cited by Convergent and Divergent Contribution of Vitamin A and Oxytocin to Autism Spectrum Disorder Aetiology

The dopamine hypothesis of autism spectrum disorder: A comprehensive analysis of the evidence DOI

Denis Pavǎl

International review of neurobiology, Journal Year: 2023, Volume and Issue: unknown, P. 1 - 42

Published: Jan. 1, 2023

Language: Английский

Citations

Oxytocin lipidation expanding therapeutics for long-term reversal of autistic behaviors in rats DOI

Honglin Li, Ya Chen, Yue Qiu

et al.

International Journal of Pharmaceutics, Journal Year: 2025, Volume and Issue: unknown, P. 125299 - 125299

Published: Jan. 1, 2025

Language: Английский

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Innovative biomarker exploration in ASD: Combining Graph Neural Networks and permutation testing on fMRI data DOI

Donglin Wang, Wandi Ding

Neuroimage Reports, Journal Year: 2025, Volume and Issue: 5(2), P. 100249 - 100249

Published: March 27, 2025

Language: Английский

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Intranasal oxytocin in a genetic animal model of autism DOI

Jakub Szabó, Matúš Mlynár, Andrej Feješ

et al.

Molecular Psychiatry, Journal Year: 2023, Volume and Issue: 29(2), P. 342 - 347

Published: Dec. 15, 2023

Abstract Autism spectrum disorder (ASD) is a group of neurodevelopmental disorders mainly characterized by deficient sociability and repetitive behaviors. Effective treatment for the core symptoms ASD still lacking. Behavioral interventions show limited effectiveness, while pharmacotherapy focuses on amelioration secondary symptomatology. Oxytocin (OXT) neuropeptide known its prosocial impact, making it candidate drug treatment. Its alleviating effect has been widely researched, but outcomes reported clinical studies are ambiguous. We examined daily intranasal OXT (0.8 IU/kg) administration 4 weeks ASD-like phenotype in Shank3 −/− adult mice. Animals treated with spent twice as much time interacting social partner early after 2 Furthermore, OXT-treated mice exhibited reduced explorative behavior 50%, treatment, 30% reduction behavior, termination. One-fold higher exploration due to lasted up following However, disinterest was elevated roughly 10% well, indicating form ambivalence. Obtained results support therapeutic potential intranasally administered shortfalls genetic model ASD. Subsequent research necessary elucidate benefits risks long-term administration, well applicability other models communication, which not measured present study.

Language: Английский

Citations

Prioritizing de novo potential non-canonical splicing variants in neurodevelopmental disorders DOI

Kuokuo Li,

Jifang Xiao,

Zhengbao Ling

et al.

EBioMedicine, Journal Year: 2023, Volume and Issue: 99, P. 104928 - 104928

Published: Dec. 18, 2023

Genomic variants outside of the canonical splicing site (±2) may generate abnormal mRNA splicing, which are defined as non-canonical (NCSVs). However, clinical interpretation NCSVs in neurodevelopmental disorders (NDDs) is largely unknown.

Language: Английский

Citations

Patterns of neural activity in response to threatening faces are predictive of autistic traits: modulatory effects of oxytocin receptor genotype DOI

Xiaoxiao Zheng, Feng Zhou, Meina Fu

et al.

Translational Psychiatry, Journal Year: 2024, Volume and Issue: 14(1)

Published: March 29, 2024

Autistic individuals generally demonstrate impaired emotion recognition but it is unclear whether effects are emotion-specific or influenced by oxytocin receptor (OXTR) genotype. Here we implemented a dimensional approach using an implicit task together with functional MRI in large cohort of neurotypical adult participants (N = 255, male 131, aged 17-29 years) to establish associations between autistic traits and neural behavioral responses specific face emotions, modulatory OXTR A searchlight-based multivariate pattern analysis (MVPA) revealed extensive network frontal, basal ganglia, cingulate limbic regions exhibiting significant predictability for from patterns angry relative neutral expression faces. Functional connectivity analyses genotype interaction (OXTR SNPs rs2254298, rs2268491) coupling the orbitofrontal cortex mid-cingulate during processing, negative association risk-allele group positive one non-risk allele group. Overall, results indicate primarily faces processing motivation, reward salience not early visual processing. connections these identified were only associated also Thus, altered threatening may be potential biomarker symptoms although influences need taken into account.

Language: Английский

Citations

Deciphering autism heterogeneity: a molecular stratification approach in four mouse models DOI

Lucie P. Pellissier, Caroline Gora, Ana Dudas

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: May 29, 2024

Abstract Autism spectrum disorder (ASD) is a complex neurodevelopmental condition characterized by impairments in social interaction, communication, as well restrained or stereotyped behaviors. The inherent heterogeneity within the autism poses challenges for developing effective pharmacological treatments targeting core features. Successful clinical trials require identification of robust markers to enable patient stratification. In this study, we identified molecular oxytocin and immediate early gene families across five interconnected brain structures circuit. We used wild-type four heterogeneous ASD mouse models, each exhibiting unique behavioral features along spectrum. While dysregulations family were model-specific, genes displayed widespread alterations, reflecting global changes plasticity models. Through integrative analysis, Egr1, Foxp1, Homer1a, Oxt Oxtr discriminant that allowed successful stratification Importantly, our demonstrated predictive values when challenged with fifth model identifying subgroups mice potentially responsive treatment. Beyond providing insights into mRNA dynamics, proof-of-concept study represents significant step toward potential individuals ASD. This work has implications success development personalized medicine autism.

Language: Английский

Citations

Effects of music therapy with Ayurvedic head massage for patients with Autism Spectrum Disorder (ASD) by bioresonance method DOI

Yumi Fukuda,

Tsuyoshi Kitanishi,

Sharma Inamura Hiroe

et al.

International Journal of Complementary & Alternative Medicine, Journal Year: 2024, Volume and Issue: 17(1), P. 33 - 36

Published: Feb. 20, 2024

Autism Spectrum Disorder (ASD) has attracted attention for difficulty with social communication, where valid exam and treatment are expected. Current cases include 2 patients (32F/13M) ASD their mothers (61F/43F). They received procedures of music therapy (MT), Ayurvedic head massage, measured the changes in values bio resonance apparatus before after intervention. As a result, oxytocin brought remarkable improvement among dopamine, GABA, serotonin, autonomic nerve, autism others. Questionnaire survey showed satisfactory evaluation from all subjects. These results suggest that combined therapeutic trials would contribute ASD, leading to future possibility treatment.

Language: Английский

Citations

Deciphering autism heterogeneity: a molecular stratification approach in four mouse models DOI

Caroline Gora, Ana Dudas,

Océane Vaugrente

et al.

Translational Psychiatry, Journal Year: 2024, Volume and Issue: 14(1)

Published: Oct. 4, 2024

Language: Английский

Citations

Oxytocin - A key to aetiology and treatment for Autism Spectrum Disorder DOI

Rong Zhang

EBioMedicine, Journal Year: 2022, Volume and Issue: 81, P. 104126 - 104126

Published: June 24, 2022

The finding that the hypothalamic neuropeptide oxytocin (OXT) plays a key role in social cognition and behavior is one of most significant discoveries neuroscience. Since 1987, when work by Keith Kendrick Cambridge firstly demonstrated OXT played central both maternal mother-infant bonds sheep,1Kendrick K.M. Keverne E.B. Baldwin B.A. Intracerebroventricular stimulates behaviour sheep.Neuroendocrinology. 1987; 46: 56-61https://doi.org/10.1159/000124796Crossref PubMed Scopus (272) Google Scholar it has subsequently been reported to be deeply involved enhancing socially relevant recognition, cognition, memory, reward, empathy, co-operation attachment behaviors. Autism spectrum disorder (ASD) developmental characterized deficits interaction communication as well restricted repetitive behaviors atypical sensory responses, increasingly proposed factor ASD aetiology promising potential treatment. primarily genetic known miR-6126, which targets genes enriched signaling pathway, downregulated variants receptor (OXTR) are associated with ASD, such rs7632287, rs237887, rs2268491, rs2254298. Other OXTR variants, like rs2254298 rs53576, may also modulate efficacy intranasal facilitating some aspects processing symptoms. However, there several unsolved mysteries this field. For example, why do autism animal models generated targeting other show dysfunction system even though mutations or themselves have relativelyweak association these genes. Although meta-analysis peripheral concentrations tend lower autistic children,2John S. Jaeggi A.V. Oxytocin levels children: 31 studies.Autism. 2021; 25: 2152-2161https://doi.org/10.1177/13623613211034375Crossref (23) findings concerning therapy were inconsistent.3Sikich L. Kolevzon A. King B.H. et al.Intranasal children adolescents disorder.N Engl J Med. 385: 1462-1473https://doi.org/10.1056/NEJMoa2103583Crossref (84) Scholar,4Yatawara C.J. Einfeld S.L. Hickie I.B. Davenport T.A. Guastella A.J. effect nasal spray on observed young autism: randomized clinical crossover trial.Mol Psychiatry. 2016; 21: 1225-1231https://doi.org/10.1038/mp.2015.162Crossref (224) article "Integrative Analysis Prioritized Oxytocin-related Biomarkers Associated Aetiology Spectrum Disorder"5Wang T. Zhao Liu al.Integrative analysis prioritised oxytocin-related biomarkers disorder.EBioMedicine. 2022; 81104091https://doi.org/10.1016/j.ebiom.2022.104091Summary Full Text PDF (3) recent issue eBioMedicine tries answer aforementioned question allows us rethink OXT-related translational medicine. In paper, 963 (OTRGs) included 208 them defined core OTGRs, carried probands higher coding de novo (DNM) burden than controls, especially loss-of-function (Lof) DNMs. authors found: (1) copy number variations (dnCNVs) probands, 28.98% OTRGs, contribution OTRGs was significantly order dnCNVs> inherited CNVs (ihCNVs)>DNMs at individual level; (2) OTRG-associated dnCNV burdens female gender non-verbal intelligence quotient (NVIQ) ≤50. 93.33% (28/30) high- 85.92% (122/142) low positively contributed (PC-OTRGs) least four pathways, namely "OXT pathway", "GPCR ligand binding", "MAPK pathway" "signaling tyrosine kinases". Among 30 high PC-OTRGs, MAPK3 prominent gene, followed SHANK3, NLGN4X NLGN3; (4) based rare disrupted variations, 458 molecular identified, including 172 PC-OTRGs 286 connected them, functional DNMs pathogenic affected ∼10% ∼1% patients correspondingly. About 66.98% aetiology, 59.44% chromatin organization, nervous development synaptic function. addition findings, influenced biological factors embryonic early postnatal stages, sex hormones, neurotransmitters growth (serotonin, alpha- melanocyte stimulating hormone, cholecystokinin, brain derived neurotrophic etc). Social physical stimulation (sucking, touching, eye-contact) will influence status system.6Zhang R. Xu X.J. Zhang H.F. Han S.P. J.S. oxytocin/arginine vasopressin disorder.Adv Anat Embryol Cell Biol. 2017; 224: 135-158https://doi.org/10.1007/978-3-319-52498-6_8Crossref (14) It important pay attention mothers themselves, since not only but their plasma negatively symptoms children.7Xu Shou Li J. al.Mothers Arg-vasopressin level testosterone.PLoS One. 2013; 8: e74849https://doi.org/10.1371/journal.pone.0074849Crossref (44) rate cesarean section8Liu K.Y. Teitler J.O. Rajananda al.Elective deliveries risk autism.Am Prev : 68-76https://doi.org/10.1016/j.amepre.2022.01.024Summary lactation,9Soke G.N. Maenner M. Windham G. al.Association between breastfeeding initiation duration preschool enrolled study explore development.Autism Res. 2019; 12: 816-829https://doi.org/10.1002/aur.2091Crossref (26) bonding lead for through epigenetic modification. Therefore, genetics environment next hotspot diagnosis precision ASD. Finally, paper presents full view real world, helpful understand Furthermore, contributes understanding pharmacological intervention strategy should conform requirements medicine, so increase response level. fact, double-blind, randomized, design trial performed team China shown treatment positive interactions can improve given every day 24 IU. Meanwhile, rs2268491 SNP genotype showed modulating effects greater Responsiveness Scale-2 improvements concentration changes.10Le W. al.Infrequent improves pilot trial.Psychother Psychosom. May 11: 1-13https://doi.org/10.1159/000524543Crossref (13) This took into account practical factors, drug dosage frequency, administrate an adjunction experience interaction, thus providing new successful model therapy. More trials needed extensively consider more genotypes phenotypes (sex, language NVIQ) future. author declares no competing interests. research supported grants from Key Realm R&D Program Guangdong Province (Grant/Award Number: 2019B030335001), Beijing Municipal Science & Technology Commission Z181100001518005), University IUR Innovation Foundation (Dezhou) 2021DZ021). Integrative disorderOur suggest disruptive predicting Full-Text Open Access

Language: Английский

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