Microplastics in human blood: Polymer types, concentrations and characterisation using μFTIR DOI Creative Commons
Sophie V. L. Leonard,

Catriona R. Liddle,

Charlotte A. Atherall

et al.

Environment International, Journal Year: 2024, Volume and Issue: 188, P. 108751 - 108751

Published: May 14, 2024

Microplastics (MPs) are an everyday part of life, and now ubiquitous in the environment. Crucially, MPs have not just been found within environment, but also human bodies, including blood. We aimed to provide novel information on range MP polymer types present, as well their size shape characteristics, whole blood from 20 healthy volunteers. Twenty-four were identified 18 out (90 %) donors quantified blood, with majority observed for first time. Using LOQ approach, five met threshold a lower mean ± SD 2466 4174 MP/L. The concentrations plastics analysed samples ranged 1.84 - 4.65 μg/mL. Polyethylene (32 %), ethylene propylene diene (14 ethylene-vinyl-acetate/alcohol (12 fragments most abundant. particles that had particle length 127.99 293.26 µm (7-3000 µm), width 57.88 88.89 (5-800 µm). predominantly categorised (88 white/clear (79 %). A variety plastic additive chemicals endocrine disrupting-classed phthalates. procedural blank comprised 7 types, distinct those mainly resin (25 polyethylene terephthalate (17 polystyrene 4.80 5.59 This study adds growing evidence taken up into body transported via bloodstream. sizes raise important questions respect presence associated hazards terms potential detrimental impacts such vascular inflammation, build major organs, changes either immune cell response, or haemostasis thrombosis.

Language: Английский

A new quantitative insight: Interaction of polyethylene microplastics with soil - microbiome - crop DOI Open Access
Ying Zhang, Shuo Yang,

Yuping ZENG

et al.

Journal of Hazardous Materials, Journal Year: 2023, Volume and Issue: 460, P. 132302 - 132302

Published: Aug. 17, 2023

Language: Английский

Citations

49
The microplastics exposure induce the kidney injury in mice revealed by RNA-seq DOI Creative Commons

Xi Xiong,

Likun Gao, Chen Chen

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 256, P. 114821 - 114821

Published: March 28, 2023

Microplastics (MPs) may pollute drinking water, accumulate in the food chain, and release toxic chemicals that cause a variety of diseases. The detrimental effects MPs on kidney injury fibrosis under long-term accumulation have not been fully documented. In this study, mice were exposed to with three different diameters (80 nm, 0.5 µm, 5 µm) investigate influences kidney. results showed caused varying degrees murine exposure can induce an inflammatory response, oxidative stress, cell apoptosis injury, which ultimately promotes fibrosis. Furthermore, transcriptome data revealed chronic could alter expressions multiple genes related immune response nm) circadian rhythm (0.5 µm). Overall, our provide new evidence potential research for investigating harm mammals even humans.

Language: Английский

Citations

45
Acute Exposure to Microplastics Induced Changes in Behavior and Inflammation in Young and Old Mice DOI Open Access

Lauren Gaspar,

Sydney Bartman, Giuseppe Coppotelli

et al.

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(15), P. 12308 - 12308

Published: Aug. 1, 2023

Environmental pollutants have become quite ubiquitous over the past two centuries; of those, plastics, and in particular, microplastics (<5 mm), are among most pervasive pollutants. Microplastics (MPs) found their way into air, water system, food chain either purposely produced or derived from breakdown larger plastic materials. Despite societal advancements that plastics allowed, mismanagement waste has a pressing global issue. Pioneering studies on MPs toxicity shown exposure to induces oxidative stress, inflammation, decreased cell viability marine organisms. Current research suggests these transported throughout environment can accumulate human tissues; however, health effects MPs, especially mammals, is still very limited. This led our group explore biological cognitive consequences rodent model. Following three-week treated with fluorescently-labeled pristine polystyrene young old C57BL/6J mice were assessed using behavioral assays, such as open-field light-dark preference, followed by tissue analyses fluorescent immunohistochemistry, Western blot, qPCR. Data assays suggest short-term both changes well alterations immune markers liver brain tissues. Additionally, we noted differed depending age, indicating possible age-dependent effect. These findings need for further better understand mechanisms which may induce physiological changes.

Language: Английский

Citations

45
Microplastics, a Global Issue: Human Exposure through Environmental and Dietary Sources DOI Creative Commons

Lucrezia Borriello,

Marcello Scivicco, Nunzio Antonio Cacciola

et al.

Foods, Journal Year: 2023, Volume and Issue: 12(18), P. 3396 - 3396

Published: Sept. 11, 2023

Plastic production has grown dramatically over the years. Microplastics (MPs) are formed from fragmentation of larger plastic debris by combining chemical, physical, and biological processes can degrade further to form nanoplastics (NPs). Because their size, MPs NPs bioavailable many organisms reach humans through transport along food chain. In addition risk ingesting themselves, there risks associated with substances they carry, such as pesticides, pathogenic microorganisms, heavy metals, additives added plastics improve characteristics. addition, bioaccumulation biomagnification cause a cumulative exposure effect for at top chain humans. Despite growing scientific interest in this emerging contaminant, potential adverse effects remain unclear. The aim review is summarize characteristics (size, shape, color, properties) environment, primary sources, pathways various environmental compartments, shed more light on ecological impact health identifying human pathways.

Language: Английский

Citations

43
Microplastics in human blood: Polymer types, concentrations and characterisation using μFTIR DOI Creative Commons
Sophie V. L. Leonard,

Catriona R. Liddle,

Charlotte A. Atherall

et al.

Environment International, Journal Year: 2024, Volume and Issue: 188, P. 108751 - 108751

Published: May 14, 2024

Microplastics (MPs) are an everyday part of life, and now ubiquitous in the environment. Crucially, MPs have not just been found within environment, but also human bodies, including blood. We aimed to provide novel information on range MP polymer types present, as well their size shape characteristics, whole blood from 20 healthy volunteers. Twenty-four were identified 18 out (90 %) donors quantified blood, with majority observed for first time. Using LOQ approach, five met threshold a lower mean ± SD 2466 4174 MP/L. The concentrations plastics analysed samples ranged 1.84 - 4.65 μg/mL. Polyethylene (32 %), ethylene propylene diene (14 ethylene-vinyl-acetate/alcohol (12 fragments most abundant. particles that had particle length 127.99 293.26 µm (7-3000 µm), width 57.88 88.89 (5-800 µm). predominantly categorised (88 white/clear (79 %). A variety plastic additive chemicals endocrine disrupting-classed phthalates. procedural blank comprised 7 types, distinct those mainly resin (25 polyethylene terephthalate (17 polystyrene 4.80 5.59 This study adds growing evidence taken up into body transported via bloodstream. sizes raise important questions respect presence associated hazards terms potential detrimental impacts such vascular inflammation, build major organs, changes either immune cell response, or haemostasis thrombosis.

Language: Английский

Citations

43