bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Feb. 12, 2024
Abstract
The
influence
of
SARS-CoV-2
non-structural
protein
in
the
host’s
tissue-specific
complexities
remains
a
mystery
and
needs
more
in-depth
attention
because
COVID-19
recurrence
long
COVID.
Here
we
investigated
transmembrane
NSP6
(Non-structural
6)
three
major
organs
-
brain,
heart,
lung
silico.
To
elucidate
interplay
between
host
proteins,
analyzed
protein-protein
interaction
network
proteins
interacting
with
proteins.
Reported
partners
were
ATP5MG,
ATP6AP1,
ATP13A3,
SIGMAR1.
Pathway
enrichment
analyses
provided
global
insights
into
biological
pathways
governed
by
differentially
regulated
genes
tissues
after
infection.
Hub
interactome
analysed
for
drug
targets
many
found.
miRNA-gene
was
sought.
Comparing
this
list
gene
targetted
miRNAs,
found
two
common
brain
respectively.
Among
five
revealed
as
potential
therapeutic
across
tissues,
four
non-approved
drugs
one
approved
could
target
Galectin
3
(LGALS3)
AIFM1
Increased
expression
LGALS3
(that
upregulated
heart
infection)
is
observed
multiple
cancers
acts
modulator
tumor
progression.
infection
also
causes
myocardial
inflammation
failure
(HF).
HF
to
be
increasing
cancer
incidence.
present
scenario
recurrent
infections
warrants
studies
probe
effect
on
increased
Graphical
International Journal of Molecular Sciences,
Journal Year:
2023,
Volume and Issue:
24(8), P. 7445 - 7445
Published: April 18, 2023
In
addition
to
the
acute
symptoms
after
infection,
patients
and
society
are
also
being
challenged
by
long-term
effects
of
COVID-19,
known
as
long
COVID.
Oxidative
stress,
a
pivotal
point
in
pathophysiology
could
potentially
be
involved
development
post-COVID
syndrome.
The
aim
present
study
was
evaluate
relationship
between
changes
oxidative
status
persistence
long-COVID
workers
with
previous
mild
COVID-19
infection.
A
cross-sectional
conducted
among
127
employees
an
Italian
university
(80
47
healthy
subjects).
TBARS
assay
used
detect
malondialdehyde
serum
levels
(MDA),
while
total
hydroperoxide
(TH)
production
measured
d-ROMs
kit.
significant
difference
mean
MDA
values
found
previously
infected
subjects
controls
(4.9
µm
vs.
2.8
µm,
respectively).
Receiver–operating
characteristic
(ROC)
curves
showed
high
specificity
good
sensibility
(78.7%
67.5%,
respectively)
for
levels.
random
forest
classifier
identified
hematocrit
value,
levels,
IgG
titer
against
SARS-CoV-2
features
highest
predictive
value
distinguishing
34
from
46
asymptomatic
subjects.
damage
persists
suggesting
possible
role
stress
mediators
pathogenesis
Frontiers in Immunology,
Journal Year:
2024,
Volume and Issue:
15
Published: May 14, 2024
COVID-19
vaccines
are
highly
effective
in
inducing
protective
immunity.
While
the
serum
antibody
response
to
vaccination
has
been
studied
depth,
our
knowledge
of
underlying
plasmablast
and
memory
B
cell
(Bmem)
responses
is
still
incomplete.
Here,
we
determined
a
naïve
population
contrasted
it
with
single
influenza
primed
cohort.
In
addition,
analyzed
against
four
endemic
human
coronaviruses
(HCoVs).
Journal of the Formosan Medical Association,
Journal Year:
2024,
Volume and Issue:
123(7), P. 811 - 817
Published: Feb. 14, 2024
The
SARS-CoV-2
virus
has
been
a
global
public
health
threat
since
December
2019.
This
study
aims
to
investigate
the
neurological
characteristics
and
risk
factors
of
coronavirus
disease
2019
(COVID-19)
in
Taiwanese
children,
using
data
from
collaborative
registry.
A
retrospective,
cross-sectional,
multi-center
was
done
an
online
network
pediatric
COVID-19
cohort
total
11160
COVID-19-associated
emergency
department
(ED)
visits
1079
hospitalizations
were
analyzed.
Seizures
most
common
specific
symptom,
while
encephalitis
acute
disseminated
encephalomyelitis
(ADEM)
prevalent
severe
involvement.
In
ED
patients
with
manifestations,
diagnosis
associated
visual
hallucination,
seizure
with/without
fever,
behavior
change,
decreased
GCS,
myoclonic
jerk,
activity/fatigue,
lethargy.
hospitalized
fatigue,
hypoglycemia
at
admission.
Encephalitis/ADEM
only
factor
for
poor
outcomes
discharge
patients.
Neurological
complications
are
COVID-19.
Visual
seizure,
admission
important
warning
signs
involvement
such
as
encephalitis/ADEM.
Biomedical Journal,
Journal Year:
2024,
Volume and Issue:
unknown, P. 100766 - 100766
Published: July 1, 2024
Severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
interacts
between
the
host
and
virus
govern
induction,
resulting
in
multiorgan
impacts.
Its
pathophysiology
involves
followings:
1)
angiotensin-converting
enzyme
(ACE2)
Toll-like
receptor
(TLR)
pathways:
2)
neuropilin
(NRP)
pathway:
3)
spike
protein
pathway.
Therefore,
it
is
necessary
to
block
pathological
course
with
modulating
innate
lymphoid
cells
against
diverse
corona
variants
future.
Science Advances,
Journal Year:
2025,
Volume and Issue:
11(16)
Published: April 16, 2025
Antibodies
play
a
pivotal
role
in
the
immune
defense
and
long-term
immunity.
Yet,
while
several
studies
have
highlighted
persistence
of
antigen-specific
antibody
responses,
it
is
unclear
whether
this
stems
from
continuous
production
same
clones
or
recurrent
activation
B
cells
generating
new
clones.
To
examine
stability
human
repertoire,
we
monitored
concentrations
most
abundant
IgG1
plasma
samples
11
healthy
donors
at
nine
sampling
points
over
year.
During
year,
each
donor
received
three
doses
COVID-19
vaccine.
Notwithstanding
these
vaccinations,
remained
constant.
Given
2-
to
3-week
half-life
molecules
blood,
our
data
suggest
that
are
associated
with
immunity
do
not
undergo
somatic
hypermutation
which
would
imply
short-lived
cells.
Overall,
persistently
produced
by
long-lived
Journal of Medical Virology,
Journal Year:
2025,
Volume and Issue:
97(5)
Published: May 1, 2025
ABSTRACT
Aimed
to
comprehensively
investigate
the
presence
of
neural
autoantibodies
in
cerebrospinal
fluid
(CSF)
and
plasma
COVID‐19
patients
experiencing
neurological
complications
during
Omicron
wave
China.
Forty
consecutive
with
severe
15
disease
controls
(DC)
were
enrolled.
Neural
detected
using
both
indirect
immunofluorescence
assay
(IFA)
on
mouse
brain
tissue
Brain‐neuronal‐antigen
microarray.
Our
results
indicated
a
significantly
higher
prevalence
CSF
(62.16%
vs.
0.0%)
(38.71%
13.33%)
compared
DC.
Additionally,
we
identified
12
upregulated
intrathecal
IgG
differential
levels
between
DC,
as
well
51
plasma.
A
high
anti‐mGluR2
antibodies
(13.33%)
was
confirmed
by
cell‐based
assays.
Western
blot
analysis
showed
these
cross‐react
nucleocapsid
(N)
spike
(S)
proteins
SARS‐CoV‐2.
Notably,
strong
binding
S
protein's
RBD‐Fc
mGluR2
observed,
an
association
that
substantiated
bioinformatics
evaluating
similarity
SARS‐CoV‐2
targeted
antigens
This
finding
hints
at
potential
cross‐reactivity
protein
patients.
Research Square (Research Square),
Journal Year:
2024,
Volume and Issue:
unknown
Published: April 8, 2024
Abstract
Severe
acute
respiratory
syndrome
coronavirus
2
(SARS-CoV-2)
induces
immune-mediated
diseases.
Interactions
between
the
host
and
virus
govern
induction,
resulting
in
multiorgan
impacts.
In
2021,
as
normal
life
was
challenging
during
pandemic
era,
we
analyzed
SCI
journals
according
to
L.
Wittgenstein's
Tractatus
Logi-co-Philosophicus.
The
pathophysiology
of
disease
2019
(COVID-19)
involves
following
steps:
1)
angiotensin-converting
enzyme
(ACE2)
Toll-like
receptor
(TLR)
pathways:
2)
neuropilin
(NRP)
pathway,
with
seven
papers
continuing
twenty-four:
3)
sterile
alpha
motif
(SAM)
histidine-aspartate
domain
(HD)-containing
protein
1
(SAMHD1)
tetramerization
two
twelve:
4)
inflammasome
activation
pathways,
five
thirteen:
5)
cytosolic
DNA
sensor
cyclic-GMP-AMP
synthase
(cGAS)/stimulator
interferon
genes
(STING)
(cGAS–STING)
signaling
six
successful
eleven:
6)
spike
fourteen
twenty-three:
7)
immunological
memory
engram
thirteen
successive
eighteen:
8)
excess
acetylcholine
three
nine.
We
reconfirmed
that
COVID-19
(1-7)
pathways
a
new
pathway
involving
acetylcholine.
Therefore,
it
is
necessary
therapeutically
alleviate
block
pathological
course
harmoniously
modulating
innate
lymphoid
cells
(ILCs)
if
diverse
SARS-CoV-2
variants
are
subsequently
encountered
future.