Genes, Journal Year: 2024, Volume and Issue: 15(10), P. 1324 - 1324
Published: Oct. 14, 2024
Obstructive sleep-disordered breathing (oSDB) is a heterogeneous phenotype that increasing in prevalence worldwide and has many potential comorbidities could severely affect quality of life. There need to identify biomarkers for oSDB its improve clinical management, particularly children.
Language: Английский
Journal of Personalized Medicine, Journal Year: 2024, Volume and Issue: 14(6), P. 598 - 598
Published: June 4, 2024
Personalized sleep medicine represents a transformative shift in healthcare, emphasizing individualized approaches to optimizing health, considering the bidirectional relationship between and health. This field moves beyond conventional methods, tailoring care unique physiological psychological needs of individuals improve quality manage disorders. Key this approach is consideration diverse factors like genetic predispositions, lifestyle habits, environmental factors, underlying health conditions. enables more accurate diagnoses, targeted treatments, proactive management. Technological advancements play pivotal role field: wearable devices, mobile applications, advanced diagnostic tools collect detailed data for continuous monitoring analysis. The integration machine learning artificial intelligence enhances interpretation, offering personalized treatment plans based on individual profiles. Moreover, research circadian rhythms physiology advancing our understanding sleep’s impact overall next generation technology will integrate seamlessly with IoT smart home systems, facilitating holistic environment Telemedicine virtual healthcare platforms increase accessibility specialized care, especially remote areas. Advancements also focus integrating various sources comprehensive assessments treatments. Genomic molecular could lead breakthroughs disorders, informing highly plans. Sophisticated methods stage estimation, including techniques, are improving precision. Computational models, particularly conditions obstructive apnea, enabling patient-specific strategies. future likely involve cross-disciplinary collaborations, cognitive behavioral therapy mental interventions. Public awareness education about approaches, alongside updated regulatory frameworks security privacy, essential. Longitudinal studies provide insights into evolving patterns, further refining approaches. In conclusion, revolutionizing disorder treatment, leveraging characteristics technologies improved diagnosis, towards marks significant advancement enhancing life those
Language: Английский
Citations
6
Journal of Clinical Sleep Medicine, Journal Year: 2023, Volume and Issue: 20(1), P. 135 - 149
Published: Oct. 31, 2023
This multisociety commentary critically examines the Agency for Healthcare Research and Quality (AHRQ) final report systematic review on long-term health outcomes in obstructive sleep apnea. The AHRQ was commissioned by Centers Medicare & Medicaid Services particularly focused patient-centered of continuous positive airway pressure, variability sleep-disordered breathing metrics, validity these metrics as surrogate outcomes. raises concerns regarding conclusions their potential implications policy decisions. A major concern expressed this is that inadequately acknowledges benefits pressure several established, clinically important including excessive sleepiness, motor vehicle accidents, blood pressure. While acknowledging limited evidence treatment, especially cardiovascular outcomes, summarized report, reviews limitations recent randomized controlled trials nonrandomized studies challenges conducting future trials. research agenda to address proposed study designs may include both high quality studies. concludes highlighting safety life millions people living with apnea if alone used payers limit coverage treatment while not considering totality available evidence. Patil SP, Billings ME, Bourjeily G, et al. Long-term patients apnea: placing context-a commentary. J Clin Sleep Med. 2024;20(1):135-149.
Language: Английский
Citations
14
Annals of the American Thoracic Society, Journal Year: 2024, Volume and Issue: 21(6), P. 961 - 970
Published: Feb. 8, 2024
Rationale: While patients with obstructive sleep apnea (OSA) have a higher risk for COVID-19 hospitalization, the causal relationship has remained unexplored. Objectives: To understand between OSA and leveraging data from vaccination electronic health records, genetic factors genome-wide association studies (GWAS) Mendelian randomization. Methods: We elucidated using FinnGen (N total = 377,277 individuals) performing association. used associated variants as instruments univariate multivariate randomization (MR) analyses computed absolute reduction (ARR) against hospitalization or without vaccination. Measurements Main Results: identified 9 novel loci replicated our findings in Million Veterans Program. Furthermore, MR analysis showed that was factor severe (P=9.41x10-4). Probabilistic modelling strongest at FTO locus reflected signal of BMI, whereas BMI independent seen earlier reported SLC9A4 MECOM which is transcriptional regulator 210-fold enrichment Finnish population. Similarly, Multivariate (MVMR) causality driven by body mass index (BMI), (P MVMR 5.97x10-6, beta=0.47). Finally, reduced more than non-OSA controls: ARR 13.3% vs. 6.3% Conclusions: Our COVID-19. The effect predominantly explained suggests BMI-dependent effects level individual comorbid causality.
Language: Английский
Citations
5
medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 2, 2025
Abstract Strong sex differences exist in sleep phenotypes and also cardiovascular diseases (CVDs). However, sex-specific causal effects of on CVD-related outcomes have not been thoroughly examined. Mendelian randomization (MR) analysis is a useful approach for estimating the effect risk factor an outcome interest when interventional studies are available. We first conducted genome-wide association (GWASs) suboptimal-sleep (insomnia, obstructive apnea (OSA), short long durations, excessive daytime sleepiness) utilizing Million Veteran Program (MVP) dataset. then developed semi-empirical Bayesian framework that (i) calibrates variant-phenotype estimates by leveraging information across groups, (ii) applies shrinkage MR analysis, to alleviate weak instrumental bias groups analyzed isolation. Simulation demonstrate derived from our substantially more efficient than those obtained through conventional methods. estimated using GWAS data MVP All Us. Significant were observed, particularly between OSA chronic kidney disease, as well duration several outcomes. By applying variable selection, we identified multiple significant relationships phenotypes.
Language: Английский
Citations
0
Neurology, Journal Year: 2025, Volume and Issue: 104(4)
Published: Jan. 21, 2025
Alzheimer disease (AD) is a heterogeneous neurodegenerative disorder influenced by genetic and environmental factors. Conditions such as type 2 diabetes (T2D), cardiovascular disease, obesity, depression, obstructive sleep apnea (OSA) increase AD risk progression. This study aimed to examine the predisposition these conditions their effect on pathophysiology, risk, A retrospective analysis was conducted using data from Alzheimer's Disease Neuroimaging Initiative (ADNI), North American prospective cohort. Polygenic scores (PRSs) for OSA, T2D, coronary artery (CAD), major body mass index (BMI) were generated 752 non-Hispanic White participants with whole-genome sequencing data. Logistic regression used evaluate associations between PRSs progression mild cognitive impairment (MCI) AD. Time across PRS quartiles analyzed Cox proportional hazards models. PET amyloid tau deposition rates, regional neocortical atrophy, composite score declines compared OSA of variance (ANOVA). Among 463 ADNI baseline MCI (mean age 72.6 ± 7.3 years, 43.4% female), PRS, adjusted BMI, significantly associated MCI-to-AD The highest quartile had an odds ratio 1.86 (95% CI 1.03-3.37) at 3 years 2.02 1.16-3.51) 5 lowest quartile. CAD, BMI not Participants in higher greater decline. In 74.1 43.6% levels amyloid, CSF amyloid-β 42, phosphorylated (p-tau), visinin-like protein 1, tumor necrosis factor receptor plasma neurofilament light after multiple testing adjustments. Individuals high polygenic susceptibility exhibited increased rate, suggesting potential modifier effects or OSA-associated genes pathophysiology. However, small sample size lack objective diagnosis limit interpretation effects.
Language: Английский
Citations
0
Journal of Clinical Laboratory Analysis, Journal Year: 2025, Volume and Issue: unknown
Published: March 10, 2025
ABSTRACT Objective Obstructive Sleep Apnea (OSA) is a common heterogeneous sleep disorder that significantly impacts the quality of individuals and leads to severe complications. Patients with OSA often experience disrupted circadian rhythm, hyperactive hypoxia response, endothelial dysfunction, yet underlying molecular mechanism remains poorly known. Recent research suggests promising evidence potential role SIRT1 in etiology OSA, warranting further investigation. Methods We investigated associations promoter variant (rs7895833A > G) severity 199 who underwent an overnight polysomnography at clinic. Results The minor allele frequency was observed as 0.309 males ( n = 149) 0.310 females 50). No significant were between genotypes apnea‐hypopnea index (AHI) entire sample. However, we association p 0.034) rs7895833‐G stratified by AHI. Additionally, found statistically inverse correlations age protein levels total sample 0.013) male group 0.018), suggesting age‐related expression SIRT1. Our analysis also confirmed published literature, showing AHI clinical parameters such age, BMI, Epworth sleepiness scale, neck circumference. Conclusions Overall, may indirectly affect pathogenesis, which might be influenced gender. Further detailed involving large population‐based biobanks, especially focusing on gender‐based differences, will improve our understanding management.
Language: Английский
Citations
0
Journal of Molecular and Cellular Cardiology, Journal Year: 2025, Volume and Issue: unknown
Published: March 1, 2025
Language: Английский
Citations
0
Current Sleep Medicine Reports, Journal Year: 2025, Volume and Issue: 11(1)
Published: April 15, 2025
Language: Английский
Citations
0
Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown, P. 111369 - 111369
Published: April 1, 2025
Language: Английский
Citations
0
JAMA Network Open, Journal Year: 2025, Volume and Issue: 8(4), P. e256372 - e256372
Published: April 22, 2025
Importance Women veterans are the fastest-growing veteran subpopulation in US. often experience military service–related health issues addition to conditions common all women. Because women more likely receive care civilian setting than through Department of Veterans Affairs (VA), women’s clinicians should be equipped provide patient-centered for veterans. The requires evidence-based informed by population-specific scientific literature. An updated evidence map evaluating veteran–focused literature is needed. Objective To scope and breadth veterans’ published from 2016 2023. Evidence Review In this systematic review, MEDLINE, Embase, CINAHL Complete were searched eligible articles Articles reporting about US outcomes or on providing included. Included required report patient-level that included either data only reported results separately grouped primary focus area based categories previously established VA Women’s Health research agendas prior maps. Findings volume between 2023 932 was double 8 years. largest portion focused chronic medical (137 [15%]), general mental (203 [22%]), interpersonal violence (121 3[13%]). Areas greatest growth reproductive (physical mental), pain, suicide, nonsuicidal self-injury. Additionally, emerging areas inquiry found, including military-related toxic exposures harassment within setting. Conclusions Relevance review veterans, found have doubled expanded important aligned with priorities. However, despite related several gaps remain field study. Research addressing pertinent a growing aging population will require rigorous program evaluations.
Language: Английский
Citations
0