APOBR Is Downregulated in EBV+ Tonsils of Children with Obstructive Sleep-Disordered Breathing DOI Open Access
Regie Lyn P. Santos‐Cortez,

Helen Z. Gomez,

Christina L. Elling

et al.

Genes, Journal Year: 2024, Volume and Issue: 15(10), P. 1324 - 1324

Published: Oct. 14, 2024

Obstructive sleep-disordered breathing (oSDB) is a heterogeneous phenotype that increasing in prevalence worldwide and has many potential comorbidities could severely affect quality of life. There need to identify biomarkers for oSDB its improve clinical management, particularly children.

Language: Английский

Regulatory variation at serotonin receptor 1F (HTR1F) modulates arousals and risk for sleep apnea DOI Creative Commons
Satu Strausz, Martin Broberg, Samuel E. Jones

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 29, 2024

Abstract Background Sleep apnea is a common sleep disorder affecting at least ten percent of the population. It caused by lack breathing during sleep, typically mediated obstruction airways or less frequently misdirected central signals for breathing. The primary risk factor high body mass index (BMI), causing airway obstruction. However, understanding factors in non-obese (BMI < 30) individuals requires further exploration. Aim Our goal was to elucidate genetic individuals. Methods We performed genome-wide association testing with BMI 30 FinnGen including 20,413 cases diagnosis (ICD-10 G47.3 ICD-9 3472) and 443,463 disease free controls. replicated our analysis Estonian Biobank. Results identified significant within Serotonin receptor 1F ( HTR1F ) locus (rs1818163, beta = 0.059, se 0.010, P 1.58e-8), Biobank (beta =0.042, 0.021, 0.046). signal co-localized expression across multiple tissues (posterior probability > 0.8), single cell sequencing implicated particularly neurons. Analysis eQTL data supported possible regulatory role neurons -0.03, 1.2e-4). Finally, objectively measured sleep-activity showed number awakenings night (P 5.6e-8). Conclusions findings indicate patient population range provide insight into growing evidence serotonin signaling as modulating liability apnea.

Language: Английский

Citations

0
Obstructive sleep apnea mediates genetic risk of Diabetes Mellitus: The Hispanic Community Health Study/Study of Latinos DOI Creative Commons
Yana Hrytsenko,

Brian Spitzer,

Heming Wang

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 10, 2024

We sought to evaluate whether obstructive sleep apnea (OSA), and other disorders, increase genetic risk of developing diabetes mellitus (DM).

Language: Английский

Citations

0
Using Bioinformatics and Machine Learning to Predict the Genetic Characteristics of Ferroptosis-Cuproptosis-Related Genes Associated with Sleep Deprivation DOI Creative Commons
Liang Wang, Shuo Wang,

Chujiao Tian

et al.

Nature and Science of Sleep, Journal Year: 2024, Volume and Issue: Volume 16, P. 1497 - 1513

Published: Sept. 1, 2024

Sleep deprivation (SD), a common sleep disease in clinic, has certain risks, and its pathogenesis is still unclear. This study aimed to identify ferroptosis-cuproptosis-related genes (FCRGs) associated with SD through bioinformatics machine learning, thus elucidating their biological significance clinical value.

Language: Английский

Citations

0
Obstructive sleep apnoea is independently associated with non-alcoholic fatty pancreatic disease DOI

Jiaojiao Lin,

Han Wang, Xiaoyang Chen

et al.

Scandinavian Journal of Gastroenterology, Journal Year: 2024, Volume and Issue: 59(11), P. 1252 - 1258

Published: Sept. 26, 2024

This study investigated the prevalence of non-alcoholic fatty pancreatic disease (NAFPD) in patients with obstructive sleep apnoea (OSA) and analysed correlation between them.

Language: Английский

Citations

0
APOBR Is Downregulated in EBV+ Tonsils of Children with Obstructive Sleep-Disordered Breathing DOI Open Access
Regie Lyn P. Santos‐Cortez,

Helen Z. Gomez,

Christina L. Elling

et al.

Genes, Journal Year: 2024, Volume and Issue: 15(10), P. 1324 - 1324

Published: Oct. 14, 2024

Obstructive sleep-disordered breathing (oSDB) is a heterogeneous phenotype that increasing in prevalence worldwide and has many potential comorbidities could severely affect quality of life. There need to identify biomarkers for oSDB its improve clinical management, particularly children.

Language: Английский

Citations

0