Parkinson’s disease is characterized by vitamin B6-dependent inflammatory kynurenine pathway dysfunction DOI
Edward N. Wilson, Jacob Umans, Michelle S. Swarovski

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 26, 2024

Abstract Parkinson’s disease (PD) is a complex multisystem disorder clinically characterized by motor, non-motor, and premotor manifestations. Pathologically, PD involves neuronal loss in the substantia nigra, striatal dopamine deficiency, accumulation of intracellular inclusions containing aggregates α-synuclein. Recent studies demonstrate that associated with dysregulated metabolic flux through kynurenine pathway (KP), which tryptophan converted to (KYN), KYN subsequently metabolized neuroactive compounds quinolinic acid (QA) kynurenic (KA). This multicenter study used highly sensitive liquid chromatography-tandem mass-spectrometry compare blood cerebral spinal fluid (CSF) KP metabolites between 158 unimpaired older adults 177 participants PD. Results indicate increased neuroexcitatory QA/KA ratio both plasma CSF peripheral inflammation vitamin B6 deficiency. Furthermore, QA tracked tau severity motor non-motor clinical dysfunction. Importantly, classified high degree accuracy (AUC = 0.897). Finally, analysis metabolite data revealed subgroups distinct profiles, these were found display features. Together, further support hypothesis serves as site brain periphery crosstalk, integrating B-vitamin status, metabolism ultimately influence manifestation.

Language: Английский

Abnormal kynurenine-pathway metabolites in gout: Biomarkers exploration based on orthogonal partial least squares-discriminant analysis DOI
Zhenni Liu, Lizi Jin, Zijia Ma

et al.

Clinica Chimica Acta, Journal Year: 2023, Volume and Issue: 549, P. 117531 - 117531

Published: Sept. 1, 2023

Language: Английский

Citations

3
Pseudoexfoliation Syndrome Post COVID Vaccination DOI Open Access

Gregory Russell‐Jones

Journal of Medical - Clinical Research & Reviews, Journal Year: 2024, Volume and Issue: 8(4)

Published: April 30, 2024

In an attempt to rapidly control of the unprecedented effects COVID-19 pandemic, a series vaccination programmes were rolled out across world, with paucity studies on their side-effects or efficacy. Lack testing may be reason for why there have been increasing number reports new-onset autoimmune phenomena following vaccination. These conditions include immune thrombotic thrombocytopenia, liver diseases, Guillain-Barre syndrome, IgA nephropathy, rheumatoid arthritis and systemic lupus erythematosus). It has postulated that production autoantibodies due use certain vaccine adjuvants such as PEG, used by Pfizer [1]. are somewhat more serious than side seen 2 injections Oxford-AstraZeneca (ChAdOx1 nCoV-19) (58.75%), BNT162b2 (68.5%) [2]. We report evidence extensive prolonged inflammatory response combination ChAdOx1 nCoV-19, followed 1 injection BNT162b2, which subsequently lead development irreversible eye damage typical Pseudoexfoliation in 71 year old man, excellent health no predisposing sequelae apart from his age.

Language: Английский

Citations

0
Pre- to Postbiotics: The Beneficial Roles of Pediatric Dysbiosis Associated with Inflammatory Bowel Diseases DOI Creative Commons
Roberta Ottria, Ornella Xynomilakis, Silvana Casati

et al.

Microorganisms, Journal Year: 2024, Volume and Issue: 12(8), P. 1582 - 1582

Published: Aug. 2, 2024

Probiotics are “live microorganisms which, when administered in adequate amount, confer health benefits on the host”. They can be found certain foods like yogurt and kefir dietary supplements. The introduction of bacterial derivatives has not only contributed to disease control but also exhibited promising outcomes, such as improved survival rates, immune enhancement, growth promotion effects. It is interesting note that efficacy probiotics goes beyond viability bacteria, giving rise concepts paraprobiotics, non-viable forms probiotics, postbiotics. Paraprobiotics offer various children with intestinal dysbiosis, contributing digestive health, function, overall well-being. In this review, potential these therapeutic applications alternatives pharmacological agents for treating pediatric dysbiosis will thoroughly evaluated. This includes an analysis their efficacy, safety, long-term benefits, ability restore gut microbiota balance, improve enhance reduce inflammation. aim determine if non-pharmacological interventions effectively safely manage children, reducing need conventional medications side

Language: Английский

Citations

0
Quinolinic acid degradation mediated by a unique qut cluster in Pigmentiphaga sp. YJ18 DOI
Kexin Wang,

Yinhu Jiang,

Ying Zhou

et al.

International Biodeterioration & Biodegradation, Journal Year: 2024, Volume and Issue: 195, P. 105911 - 105911

Published: Sept. 5, 2024

Citations

0
Parkinson’s disease is characterized by vitamin B6-dependent inflammatory kynurenine pathway dysfunction DOI
Edward N. Wilson, Jacob Umans, Michelle S. Swarovski

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 26, 2024

Abstract Parkinson’s disease (PD) is a complex multisystem disorder clinically characterized by motor, non-motor, and premotor manifestations. Pathologically, PD involves neuronal loss in the substantia nigra, striatal dopamine deficiency, accumulation of intracellular inclusions containing aggregates α-synuclein. Recent studies demonstrate that associated with dysregulated metabolic flux through kynurenine pathway (KP), which tryptophan converted to (KYN), KYN subsequently metabolized neuroactive compounds quinolinic acid (QA) kynurenic (KA). This multicenter study used highly sensitive liquid chromatography-tandem mass-spectrometry compare blood cerebral spinal fluid (CSF) KP metabolites between 158 unimpaired older adults 177 participants PD. Results indicate increased neuroexcitatory QA/KA ratio both plasma CSF peripheral inflammation vitamin B6 deficiency. Furthermore, QA tracked tau severity motor non-motor clinical dysfunction. Importantly, classified high degree accuracy (AUC = 0.897). Finally, analysis metabolite data revealed subgroups distinct profiles, these were found display features. Together, further support hypothesis serves as site brain periphery crosstalk, integrating B-vitamin status, metabolism ultimately influence manifestation.

Language: Английский

Citations

0