Advances in anti-tumor based on various anaerobic bacteria and their derivatives as drug vehicles

Frontiers in Bioengineering and Biotechnology, Journal Year: 2023, Volume and Issue: 11

Published: Oct. 3, 2023

Cancer therapies, such as chemotherapy and radiotherapy, are often unsatisfactory due to several limitations, including drug resistance, inability cross biological barriers, toxic side effects on the body. These drawbacks underscore need for alternative treatments that can overcome these challenges provide more effective safer options cancer patients. In recent years, use of live bacteria, engineered or bacterial derivatives deliver antitumor drugs specific tumor sites controlled release has emerged a promising therapeutic tool. This approach offers advantages over traditional targeted delivery reduced toxicity healthy tissues. Ongoing research in this field holds great potential further developing efficient personalized E. coli, Salmonella, Listeria, like outer membrane vesicles (OMVs), which serve vehicles drugs, proteins, antigens. review, we describe advances, challenges, future directions using bacteria OMVs carriers components derived from systems therapy.

Language: Английский

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Gut Microbiome and colorectal cancer: discovery of bacterial changes with metagenomics application in Turkısh population

Genes & Genomics, Journal Year: 2024, Volume and Issue: 46(9), P. 1059 - 1070

Published: July 11, 2024

Language: Английский

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Cordycepin Ameliorates High Fat Diet-Induced Obesity by Modulating Endogenous Metabolism and Gut Microbiota Dysbiosis

Nutrients, Journal Year: 2024, Volume and Issue: 16(17), P. 2859 - 2859

Published: Aug. 27, 2024

Numerous metabolic illnesses have obesity as a risk factor. The composition of the gut microbiota and endogenous metabolism are important factors in onset progression obesity. Recent research indicates that cordycepin (CRD), derived from fungi, exhibits anti-inflammatory antioxidant properties, showing potential combating However, further investigation is required to delineate its precise impacts on microbiota.

Language: Английский

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Perspective Chapter: Monocytes on the Interface of Metabolic Disorders and Colorectal Cancer

IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 27, 2024

Colorectal cancer (CRC) is a prevalent malignancy with high incidence and mortality rates worldwide. Metabolic disorders, such as obesity, dyslipidemia, hyperglycemia, hypertension, have been identified significant risk factors contributing to the development progression of CRC. These metabolic conditions often result in low-grade inflammation, which plays crucial role tumor initiation progression. Monocytes, differentiate into tumor-associated macrophages (TAMs) within microenvironment (TME), are pivotal mediating these inflammatory responses. Monocytes individuals disorders exhibit altered phenotypes functions, enhancing their pro-inflammatory tumor-promoting activities. Our review describes intricate links between CRC on level circulating monocytes, highlighting how can drive aggravate via programming immunity. Various monocyte subsets, phenotypic changes, impact elucidated, providing insights potential therapeutic targets for prevention treatment. Understanding interplay alterations monocytes-derived TAMs TME essential developing effective strategies against

Language: Английский

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The microbiome’s influence on obesity: mechanisms and therapeutic potential

Science China Life Sciences, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 28, 2024

Language: Английский

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