Ketone body metabolism and cardiometabolic implications for cognitive health DOI Creative Commons
Kyle Fulghum,

Sebastian F. Salathe,

Xin C Davis

et al.

npj Metabolic Health and Disease, Journal Year: 2024, Volume and Issue: 2(1)

Published: Oct. 11, 2024

Cardiometabolic complications of obesity present a growing public health concern and are associated with poor outcomes, mediated in part by an increased risk for cardiovascular disease, metabolic dysfunction-associated fatty liver systemic insulin resistance. Recent studies support that both resistance also aberrant brain metabolism cognitive impairment similar to what is observed neurodegenerative diseases. Central these pathological outcomes adverse changes tissue glucose ketone body metabolism, suggesting regulation substrate utilization could be mechanistic link between the cardiometabolic progression decline. Here, we review physiological conditions emphasis on therapeutic potential bodies treating diseases lead We highlight recent findings associations among while providing theoretical framework which may promote positive preserve function.

Language: Английский

Updated mechanisms of MASLD pathogenesis DOI Creative Commons
Yuxuan Li,

Peipei Yang,

Jialu Ye

et al.

Lipids in Health and Disease, Journal Year: 2024, Volume and Issue: 23(1)

Published: April 22, 2024

Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD) has garnered considerable attention globally. Changing lifestyles, over-nutrition, and physical inactivity have promoted its development. MASLD is typically accompanied by obesity strongly linked to metabolic syndromes. Given that prevalence on the rise, there an urgent need elucidate pathogenesis. Hepatic lipid accumulation generally triggers lipotoxicity induces or progress steatohepatitis (MASH) mediating endoplasmic reticulum stress, oxidative organelle dysfunction, ferroptosis. Recently, significant been directed towards exploring role of gut microbial dysbiosis in development MASLD, offering a novel therapeutic target for MASLD. Considering are no recognized pharmacological therapies due diversity mechanisms involved difficulty associated with undertaking clinical trials, potential targets remain elusive. Thus, this article aimed summarize evaluate prominent roles lipotoxicity, ferroptosis, microbes underlying their effects. Furthermore, existing advances challenges treatment were outlined.

Language: Английский

Citations

39
ONOO–-activatable and LD-traced NIR fluorescent probe for mechanism study and early diagnosis of NAFLD and diabetes induced liver injury DOI

Nannan Wang,

Xiaoyan Lu, Jiamin Wang

et al.

Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: 412, P. 135806 - 135806

Published: April 10, 2024

Language: Английский

Citations

32
Gut microbial metabolites in MASLD: Implications of mitochondrial dysfunction in the pathogenesis and treatment DOI Creative Commons
Ruhan Zhang, Zhaobo Yan, Huan Zhong

et al.

Hepatology Communications, Journal Year: 2024, Volume and Issue: 8(7)

Published: July 1, 2024

With an increasing prevalence, metabolic dysfunction-associated steatotic liver disease (MASLD) has become a major global health problem. MASLD is well-known as multifactorial disease. Mitochondrial dysfunction and alterations in the gut bacteria are 2 vital events MASLD. Recent studies have highlighted cross-talk between microbiota mitochondria, mitochondria recognized pivotal targets of to modulate host's physiological state. plays role associated with multiple pathological changes, including hepatocyte steatosis, oxidative stress, inflammation, fibrosis. Metabolites crucial mediators that influence extraintestinal organs. Additionally, regulation composition may serve promising therapeutic strategy for This study reviewed potential roles several common metabolites MASLD, emphasizing their impact on mitochondrial function. Finally, we discuss current treatments probiotics, prebiotics, antibiotics, fecal transplantation. These methods concentrate restoring promote host health.

Language: Английский

Citations

15
O-GlcNAcylation promotes the progression of nonalcoholic fatty liver disease by upregulating the expression and function of CD36 DOI
Hanlong Zhu, Tianming Zhao, Si Zhao

et al.

Metabolism, Journal Year: 2024, Volume and Issue: 156, P. 155914 - 155914

Published: April 19, 2024

Language: Английский

Citations

14
Diabetes as a risk factor for MASH progression DOI Creative Commons

Sofiya Gancheva,

Michael Roden, Laurent Castéra

et al.

Diabetes Research and Clinical Practice, Journal Year: 2024, Volume and Issue: 217, P. 111846 - 111846

Published: Sept. 6, 2024

Language: Английский

Citations

11
Bruceine A alleviates alcoholic liver disease by inhibiting AIM2 inflammasome activation via activating FXR DOI
Li Lin,

Shuai Xu,

Wenyu Wang

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 130, P. 155693 - 155693

Published: May 7, 2024

Language: Английский

Citations

6
Potential Mechanisms for Shenling Baizhu Powder in the Treatment of MAFLD Based on Network Pharmacology and Experimental Validation DOI Creative Commons
Anni Zheng, Sufei Song, Qiuling Xu

et al.

Natural Product Communications, Journal Year: 2025, Volume and Issue: 20(1)

Published: Jan. 1, 2025

Objective: To analyze the effective ingredients and molecular mechanisms of Shenling Baizhu powder (SLBZP) in treatment metabolic associated fatty liver disease (MAFLD) through network pharmacology technology experimental validation. Methods: The active components targets SLBZP were obtained from TCMS databases, GeneCards, TTD DisGeNET databases used to predict screen for MAFLD-related genes. An “herb-active components-crossover targets” was constructed using Cytoscape3.7.2 software. STRING11.5 applied construction PPI network. GO KEGG analysis performed investigate biological processes pathways involved SLBZP. Molecular docking AutoDock Vina1.1.2 validate binding ability between compounds core crossover targets. Subsequently, potential mechanism on MAFLD predicted by pharmacological experimentally studied verified. Results: 122 participated 41 identified revealed that ALB, TNF, IL1B, PPARα, PPARγ, HMOX1, PTGS2, IL6 ADIPOQ number common 263 process items 42 signal after analysis. main target protein had a good docking. Through results, shown be ameliorating lipid accumulation hepatic steatosis high-fat diet-fed rats PA-induced HepG2 cells prevent MAFLD. And results cellular experiments suggest may improve AMPK signaling pathway. Conclusion: effectively ameliorates MAFLD, related

Language: Английский

Citations

0
Andrographolide Inhibits the NF-κB Signaling Pathway and Alleviates High-Fat Diet-Induced Hepatic Inflammation in a Mouse Model of Nonalcoholic Fatty Liver Disease DOI Creative Commons

Weiwen Hu,

Yilin Chen,

Wenhong Tan

et al.

Natural Product Communications, Journal Year: 2025, Volume and Issue: 20(2)

Published: Feb. 1, 2025

Background High-fat diet (HFD)-induced nonalcoholic fatty liver disease (NAFLD) is a key link between several medical conditions and becoming major health concern affecting thousands of people globally. Andrographolide, an active ingredient extracted from Andrographis paniculate, has shown anti-inflammatory anti-fibrosis effects in recent studies. Objective This study aims to explore whether andrographolide can mitigate HFD-induced NAFLD the underlying mechanism. Methods We treated C57B/6 mice consuming high-fat (HFD) with varying concentrations andrographolide. Enzyme-linked immunosorbent assay (ELISA) was employed evaluate function indicators circulating blood. Haematoxylin Eosin Oil Red O staining were used assess inflammation infiltration lipid deposits tissues. Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) immunoblotting analyze expression levels genes proteins. Results ELISA revealed that dose-dependently mitigated elevations glucose, alanine aminotransferase, aspartate aminotransferase Histological analysis indicated reduced deposition. RT-qPCR analyses showed inhibited overproduction tumor necrosis factor (TNF)-α, interleukin (IL)-1β, IL-6, up-regulation p-p65 NLRP3 Conclusion Together, these results suggest treatment impairments, accumulation, pro-inflammatory cytokine overproduction, inflammatory responses by regulating NF-κB signaling pathway. However, it important note our are observational do not conclusively demonstrate necessity pathway's involvement NAFLD-alleviating highlights need for further validation at both gene protein through additional vitro vivo experiments.

Language: Английский

Citations

0
Biomarkers: New Advances in Diabetic Nephropathy DOI Creative Commons
Yujia Chen, Xinan Liu, Meniga Shengbu

et al.

Natural Product Communications, Journal Year: 2025, Volume and Issue: 20(2)

Published: Feb. 1, 2025

Diabetic nephropathy (DN) is the leading cause of uremia and clinical mortality, characterized by progressive deterioration kidney structure function due to prolonged exposure hyperglycemia. This condition often necessitates renal replacement therapy for patients with end-stage-renal-disease (ESRD). Consequently, early detection, diagnosis, treatment DN are crucial mitigate disease progression, enhance patient outcomes, maintain a good quality life. Exploring relevant biomarkers diagnosis holds significant importance. In recent years, numerous researchers have identified various novel associated diabetic nephropathy, which critical predicting both onset progression disease. article aims provide comprehensive overview related DN.

Language: Английский

Citations

0
Efficacy of In Vitro Addition of Low‐Dose Arachidonic Acid in Improving the Sperm Motility of Obese Infertile Men With Asthenozoospermia DOI
Yongjie Liu, Liang Dai, Fan Zhang

et al.

Journal of Biochemical and Molecular Toxicology, Journal Year: 2025, Volume and Issue: 39(3)

Published: Feb. 23, 2025

ABSTRACT This study aimed to investigate the impact of in vitro low‐dose arachidonic acid (AA) addition on enhancing sperm motility obese infertile men with asthenozoospermia. Semen samples were collected from 115 men, categorized into two BMI groups: 18.5–23.9 kg/m 2 and ≥ 28 , all subjects demonstrating a concentration 15 × 10 6 /mL. These further divided four cohorts based percentage progressive (PR): control‐normal, control‐asthenozoospermia, obese‐normal, obese‐asthenozoospermia. Normal PR was classified as 32%, while asthenozoospermia characterized by < 32%. Metabolomic analysis employed quantify seminal plasma metabolites, differential metabolites identified through statistical evaluation. Additionally, semen men—5 body mass index (BMI) 5 —underwent scrutiny. Post‐initial analysis, 1 mL stock extracted, treated 100 pg AA, incubated at 37°C for h, reanalyzed determine motility. 16 Sprague Dawley (SD) rats split control obese. The group received standard diet, subjected 45% high‐fat diet. After 3 months, euthanized via cervical dislocation, their prostate vesicles metabolite analysis. A comprehensive 4635 revealed that bile secretion emerged most significant pathway within organic systems category, accounting 0.6% total metabolites. Meanwhile, metabolic pathways overwhelmingly dominated metabolism AA contributing 4.62%. Notably, 29 associated secretion, yet no differences observed between 32% groups. In contrast, 214 linked metabolism, exhibiting predominantly downregulated trend, upregulated identified. Within network, indicators showed positive association induced acrosome reaction, Ca 2+ levels, PR, proportion grade (rapid forward motion, speed 25 μm/s). secretory phospholipase A2 (sPLA2), cyclooxygenase‐1 (COX1) levels demonstrated negative correlation anthropometric measurement parameters Control‐SP group, though this did not reach significance, evident Obesity‐SP group. concentrations sPLA2, COX1 network exhibited following trend: Control‐SP‐N > Obesity‐SP‐N Control‐SP‐A Obesity‐SP‐A. significantly enhanced B (slow‐moving, μm/s) reducing C (non‐forward‐moving) individuals ( p 0.05). those marked increase corresponding reduction noted Human elevated compared However, vesicle SD differ Control Obesity groups Distinct profiles stratified BMI, exhibit impacts quality. Low‐dose under physiological conditions, maintains integrity augments fertilization potential. administration demonstrates superior effectiveness parameters, particularly

Language: Английский

Citations

0