npj Metabolic Health and Disease,
Journal Year:
2024,
Volume and Issue:
2(1)
Published: Oct. 11, 2024
Cardiometabolic
complications
of
obesity
present
a
growing
public
health
concern
and
are
associated
with
poor
outcomes,
mediated
in
part
by
an
increased
risk
for
cardiovascular
disease,
metabolic
dysfunction-associated
fatty
liver
systemic
insulin
resistance.
Recent
studies
support
that
both
resistance
also
aberrant
brain
metabolism
cognitive
impairment
similar
to
what
is
observed
neurodegenerative
diseases.
Central
these
pathological
outcomes
adverse
changes
tissue
glucose
ketone
body
metabolism,
suggesting
regulation
substrate
utilization
could
be
mechanistic
link
between
the
cardiometabolic
progression
decline.
Here,
we
review
physiological
conditions
emphasis
on
therapeutic
potential
bodies
treating
diseases
lead
We
highlight
recent
findings
associations
among
while
providing
theoretical
framework
which
may
promote
positive
preserve
function.
Natural Product Communications,
Journal Year:
2024,
Volume and Issue:
19(12)
Published: Dec. 1, 2024
Background
Diabetes
mellitus
(DM)
is
characterized
by
irregular
carbohydrate,
protein,
and
fat
metabolism,
leading
to
elevated
blood
glucose
levels.
DM
patients
are
at
a
high
risk
of
developing
dyslipidemia
cardiovascular
chronic
kidney
diseases.
This
study
evaluated
the
impact
Jimson
weed
on
glucose,
lipid
profile,
renal
indices
using
rat
models.
Methodology
The
rats
were
divided
into
six
classes,
with
in
each
class
receiving
alloxan
intraperitoneally
orally
twice
daily
for
14
days.
assigned
classes
(A-F),
(n
=
6).
Rats
A-E
injected
2
g
dissolved
20
mL
distilled
water
(100
mg/kg
body
weight).
F
received
neither
nor
any
form
treatment.
A,
B,
C
given
100,
200,
400
leaf
extract,
while
D
5
weight
Glibenclamide.
E
normal
saline
(0.1
mL)
only.
Blood
levels
measured
Glucometer,
profile
markers
assayed
approved
procedures.
Docking
analysis
targeted
key
proteins
potential
roles
dysregulation
dysfunction
associated
diabetes.
Results
found
that
diabetes
led
abnormalities
profiles,
electrolytes,
urea,
creatinine
serum
In
diabetic
control
rats,
level
total
cholesterol
increased
over
216.67%,
concentrations
triacyglycerol
low
density
lipoprotein
also
showed
similar
trend.
Notably,
there
was
reciprocal
high-density
lipoprotein,
which
decreased
magnitude
controls
compared
rats.
other
calculated
indices;
atherogenic
coronary
indices,
Cl-,
elevated,
cardio-protective
index,
Na+,
K
+
.
ethanol
extract
alleviated
these
impacts.
investigated
compounds’
molecular
properties
docking
results
targeting
metabolic
pathways
immune
response.
compounds
promising
binding
affinities
acetyl-CoA
carboxylase
(ACC),
fatty
acid
synthase
(FASN),
3-hydroxyl-3-methyl-glutaryl-CoA
reductase
(HMG-CoAR),
melanoma
(AIM2)
proteins.
Conclusion
offers
option
treating
T2DM,
cardiovascular,
complications,
as
it
exhibits
hypolipidemic,
cardioprotective,
protective
properties,
overcoming
limitations
traditional
medicines.
Obesity Reviews,
Journal Year:
2024,
Volume and Issue:
25(9)
Published: June 16, 2024
Abstract
Obesity
is
a
worldwide
multifactorial
disease
caused
by
an
imbalance
in
energy
metabolism,
increasing
adiposity,
weight
gain,
and
promoting
related
diseases
such
as
diabetes,
cardiovascular
diseases,
neurodegeneration,
cancer.
Recent
findings
have
reported
that
metabolic
stress
to
obesity
induces
mitochondrial
response
called
unfolded
protein
(UPR
mt
),
quality
control
pathway
occurs
nuclear
DNA–mitochondria
crosstalk,
causing
transduction
of
chaperones
proteases
under
conditions.
The
duality
UPR
signaling,
with
both
beneficial
detrimental
effects,
acts
different
contexts
depending
on
the
tissue,
cell
type,
physiological
states,
affecting
function
efficiency
metabolism
homeostasis
during
obesity,
which
remains
not
fully
clarified.
Therefore,
this
review
discusses
most
recent
regarding
signaling
bringing
overview
across
tissues.
bioRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: June 27, 2024
Summary
Abnormal
mitochondrial
oxidative
phosphorylation
(OXPHOS)
is
key
to
the
pathogenesis
of
several
cardiometabolic
diseases.
The
ketone
bodies
(KBs),
β-hydroxybutyrate
(HBA)
and
acetoacetate
(ACA),
are
critical
for
tissue-specific
energy
metabolism
under
various
pathophysiological
conditions.
However,
robust
methods
quantifying
their
contribution
as
substrates
OXPHOS
lacking.
Here,
we
first
established
comprehensive
high-resolution
respirometry
protocols
assessing
differential
contributions
HBA,
ACA,
related
ketolytic
enzymes
in
translational
studies
mice
humans.
We
then
utilized
these
demonstrate
(i)
organ-specific
differences
KB-driven
respiration
mice,
(ii)
lower
liver
humans
with
steatosis,
skeletal
muscle
diabetes
kidney
diet-induced
obese
well
(iii)
higher
KB
utilization
capacity
mouse
human
failing
heart.
These
results
highlight
roles
diseases
shall
help
identify
novel
targets
pathways.
npj Metabolic Health and Disease,
Journal Year:
2024,
Volume and Issue:
2(1)
Published: Oct. 11, 2024
Cardiometabolic
complications
of
obesity
present
a
growing
public
health
concern
and
are
associated
with
poor
outcomes,
mediated
in
part
by
an
increased
risk
for
cardiovascular
disease,
metabolic
dysfunction-associated
fatty
liver
systemic
insulin
resistance.
Recent
studies
support
that
both
resistance
also
aberrant
brain
metabolism
cognitive
impairment
similar
to
what
is
observed
neurodegenerative
diseases.
Central
these
pathological
outcomes
adverse
changes
tissue
glucose
ketone
body
metabolism,
suggesting
regulation
substrate
utilization
could
be
mechanistic
link
between
the
cardiometabolic
progression
decline.
Here,
we
review
physiological
conditions
emphasis
on
therapeutic
potential
bodies
treating
diseases
lead
We
highlight
recent
findings
associations
among
while
providing
theoretical
framework
which
may
promote
positive
preserve
function.
