Analysis of Prognostic Factors and Establishment of a Nomogram to Predict Risk for COVID-19 Convalescent Patients Based on Metabolomic and Lipidomic DOI Creative Commons

Anzhu Wang,

Yingying Yang, Peng Miao

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: March 8, 2024

Abstract Ethnopharmacological relevance: Qimai Feiluoping Mixture (QM) is a traditional Chinese herbal formulation that has demonstrated efficacy in improving both clinical symptoms and radiological indications of pulmonary fibrosis patients convalescing from Coronavirus Disease 2019 (COVID-19). Aim the study: To analyze factors associated with prognosis COVID-19 patients. It seeks to develop validate nomogram based on metabolomic lipidomic for predicting improvements lung imaging Additionally, study evaluates application value this nomogram. Methods materials: A retrospective analysis was conducted data recovery January 2020 April 2022. Non-targeted plasma were performed using LC-MS normal phase (NP)-HPLC coupled mass spectrometry. Patients divided into training validation sets 7:3 ratio their omics data. Multivariate logistic regression identify independent risk imaging. Based these factors, prediction model developed. The evaluated receiver operating characteristic (ROC) curves calibration curves. In addition, decision curve (DCA) assess performance predictive applications. Results use QM found be (P < 0.05). Among 75 metabolites detected test 32 lipids identified test, Pro Ser Val, PC36:1(18:0_18:1), BMP36:3(18:2_18:1) utilized constructing model. good discriminative ability, an Area Under Curve (AUC) 0.821 (95% CI: 0.718–0.924) set 0.808 0.627–0.989) set. indicated agreement between predicted probabilities actual sets. Finally, DCA suggested utility. Conclusion utilization may beneficially influence COVID-19. straightforward nomogram, developed lipidomic, could valuable tool clinicians predict likelihood

Language: Английский

Long COVID science, research and policy DOI Creative Commons
Ziyad Al‐Aly, Hannah Davis, Lisa McCorkell

et al.

Nature Medicine, Journal Year: 2024, Volume and Issue: 30(8), P. 2148 - 2164

Published: Aug. 1, 2024

Long COVID represents the constellation of post-acute and long-term health effects caused by SARS-CoV-2 infection; it is a complex, multisystem disorder that can affect nearly every organ system be severely disabling. The cumulative global incidence long around 400 million individuals, which estimated to have an annual economic impact approximately $1 trillion-equivalent about 1% economy. Several mechanistic pathways are implicated in COVID, including viral persistence, immune dysregulation, mitochondrial dysfunction, complement endothelial inflammation microbiome dysbiosis. devastating impacts on individual lives and, due its complexity prevalence, also has major ramifications for systems economies, even threatening progress toward achieving Sustainable Development Goals. Addressing challenge requires ambitious coordinated-but so far absent-global research policy response strategy. In this interdisciplinary review, we provide synthesis state scientific evidence assess human health, systems, economy metrics, forward-looking roadmap.

Language: Английский

Citations

109
The persistence of SARS-CoV-2 in tissues and its association with long COVID symptoms: a cross-sectional cohort study in China DOI Creative Commons
Wenting Zuo,

Di He,

Chaoyang Liang

et al.

The Lancet Infectious Diseases, Journal Year: 2024, Volume and Issue: 24(8), P. 845 - 855

Published: April 22, 2024

Growing evidence suggests that symptoms associated with post-COVID-19 condition (also known as long COVID) can affect multiple organs and systems in the human body, but their association viral persistence is not clear. The aim of this study was to investigate SARS-CoV-2 diverse tissues at three timepoints following recovery from mild COVID-19, well its COVID symptoms.

Language: Английский

Citations

62
Unravelling shared mechanisms: insights from recent ME/CFS research to illuminate long COVID pathologies DOI Creative Commons
Sarah J. Annesley, Daniel Missailidis, Benjamin Heng

et al.

Trends in Molecular Medicine, Journal Year: 2024, Volume and Issue: 30(5), P. 443 - 458

Published: March 4, 2024

Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a debilitating chronic illness often triggered by an initiating acute event, mainly viral infections. The transition from to disease remains unknown, but interest in this phenomenon has escalated since the COVID-19 pandemic and post-COVID-19 illness, termed 'long COVID' (LC). Both ME/CFS LC share many clinical similarities. Here, we present recent findings research focussing on proposed pathologies shared with LC. Understanding these how they influence each other key developing effective therapeutics diagnostic tests. Given that typically longer duration compared LC, symptoms evolving over time, may provide insights into future progression of

Language: Английский

Citations

14
Systems analysis of innate and adaptive immunity in Long COVID DOI
Michael J. Peluso, Mohamed Abdel‐Mohsen, Timothy J. Henrich

et al.

Seminars in Immunology, Journal Year: 2024, Volume and Issue: 72, P. 101873 - 101873

Published: March 1, 2024

Language: Английский

Citations

14
Early use of oral antiviral drugs and the risk of post COVID-19 syndrome: A systematic review and network meta-analysis DOI
Juan Jiang,

Yantong Li,

Qiaoling Jiang

et al.

Journal of Infection, Journal Year: 2024, Volume and Issue: 89(2), P. 106190 - 106190

Published: June 2, 2024

Language: Английский

Citations

10
Long COVID facts and findings: a large-scale online survey in 74,075 Chinese participants DOI Creative Commons

Shijie Qin,

Yanan Zhang,

Yanhua Li

et al.

The Lancet Regional Health - Western Pacific, Journal Year: 2024, Volume and Issue: 52, P. 101218 - 101218

Published: Oct. 11, 2024

Language: Английский

Citations

8
Multi‐Omics Analysis by Machine Learning Identified Lysophosphatidic Acid as a Biomarker and Therapeutic Target for Porcine Reproductive and Respiratory Syndrome DOI Creative Commons
Hao Zhang,

Fangyu Hu,

Ouyang Peng

et al.

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: July 8, 2024

As a significant infectious disease in livestock, porcine reproductive and respiratory syndrome (PRRS) imposes substantial economic losses on the swine industry. Identification of diagnostic markers therapeutic targets has been focal challenge PPRS prevention control. By integrating metabolomic lipidomic serum analyses clinical pig cohorts through machine learning approach with vivo vitro infection models, lysophosphatidic acid (LPA) is discovered as metabolic biomarker for PRRS virus (PRRSV) diagnosis. PRRSV promoted LPA synthesis by upregulating autotaxin expression, which causes innate immunosuppression dampening retinoic acid-inducible gene I (RIG-I) type interferon responses, leading to enhanced replication. Targeting demonstrated protection against associated outcomes infected pigs, indicating that novel antiviral target PRRSV. This study lays foundation control infections.

Language: Английский

Citations

4
Immune responses in COVID-19 patients: Insights into cytokine storms and adaptive immunity kinetics DOI Creative Commons
J Zhang

Heliyon, Journal Year: 2024, Volume and Issue: 10(14), P. e34577 - e34577

Published: July 1, 2024

SARS-CoV-2 infection can trigger cytokine storm in some patients, which characterized by an excessive production of cytokines and chemical mediators. This hyperactive immune response may cause significant tissue damage multiple organ failure (MOF). The severity COVID-19 correlates with the intensity storm, involving elements such as IFN, NF-κB, IL-6, HMGB1, etc. It is imperative to rapidly engage adaptive immunity effectively control disease progression. CD4

Language: Английский

Citations

4
Potential Biomarkers for Predicting the Risk of Developing Into Long COVID After COVID‐19 Infection DOI Creative Commons
Zhiyong Hou,

Yu Ming,

Jun Liu

et al.

Immunity Inflammation and Disease, Journal Year: 2025, Volume and Issue: 13(1)

Published: Jan. 1, 2025

ABSTRACT Background Long COVID, a heterogeneous condition characterized by range of physical and neuropsychiatric presentations, can be presented with proportion COVID‐19‐infected individuals. Methods Transcriptomic data sets those within gene expression profiles COVID‐19, long healthy controls were retrieved from the GEO database. Differentially expressed genes (DEGs) falling under COVID‐19 COVID identified R packages, contemporaneously conducted module detection was performed Modular Pharmacology Platform ( http://112.86.129.72:48081/ ). The integration both DEGs differentially module‐genes (DEMGs) regarding intersected following Gene Ontology (GO), Kyoto Encyclopedia Genes Genomes (KEGG), Set Enrichment Analysis (GSEA). Results There 11 62 modules, 1837 179 DEGs, as well 103 508 DEMGs acquiring for notably enriched in immune‐correlated signaling pathways. immune infiltrating cells comparatively respectively assessed via CIBERSORT, ssGSEA, xCell algorithms. Subsequently, screening hub involved employing SVM‐RFE, RF, XGBoost algorithms, logistic regression analysis. Among 67 candidate processed machine learning algorithms regression, subgroup consisting CEP55, CDCA2, MELK, DEPDC1B, at last potential biomarkers predicting risk progression into after infections. performance quantified ROC value 0.8762542, which proved combination provided highest performance. Conclusions In summary, we infection, could partly elucidation associated molecular mechanisms COVID.

Language: Английский

Citations

0
Exploring DNA methylation, telomere length, mitochondrial DNA, and immune function in patients with Long-COVID DOI Creative Commons
Andrea Polli, Lode Godderis, Dries S. Martens

et al.

BMC Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 4, 2025

Long-COVID is defined as the persistency or development of new symptoms 3 months after initial SARS-CoV-2 infection, with these lasting for at least 2 no other explanation. Common persistent are fatigue, sleep disturbances, post-exertional malaise (PEM), pain, and cognitive problems. estimated to be present in about 65 million people. We aimed explore clinical biological factors that might contribute Long-COVID. Prospective longitudinal cohort study including patients infected between March 2020 2022. Patients were assessed 4 12 infection COVID follow-up clinic UZ Leuven. performed a comprehensive assessment (including questionnaires 6-min walking test) measures (global DNA methylation, telomere length, mitochondrial copy number, inflammatory cytokines, serological markers such C-reactive protein, D-dimer, troponin T). Of 358 participants, 328 hospitalised, which 130 had severe requiring intensive care admission; 30 ambulatory referrals. Based on their presentation, we could identify 6 main clusters. One-hundred twenty-seven (35.4%) belonged one cluster. The bigger cluster included PEM, pain (n = 57). Troponin T shortening two predicting PEM-fatigue symptoms. not just entity. Different presentations can identified. Cardiac involvement (as measured by levels) relevant risk factor developing deserve further exploring.

Language: Английский

Citations

0