BMC Geriatrics, Journal Year: 2024, Volume and Issue: 24(1)
Published: Dec. 19, 2024
This study aimed to investigate the modulatory role of prefrontal cortex (PFC) activity in older adults with mild cognitive impairment (MCI) when sensory cues were removed or presented inaccurately (i.e., increased complexity) during manipulation a balance task. The research sheds light on neural regulatory mechanisms brain related control individuals MCI.
Language: Английский
Molecular Neurodegeneration, Journal Year: 2024, Volume and Issue: 19(1)
Published: Dec. 4, 2024
Abstract Multisensory decline is common as people age, and aging the primary risk of Alzheimer’s Disease (AD). Recent studies have begun to shed light on possibility that age-related sensory could accelerate AD pathogenesis, or be a prodromal indicator AD. Sensory impairments, specifically in taste smell, often emerge before cognitive symptoms AD, indicating their potential early biomarkers. Olfactory dysfunction has been frequently associated with may offer valuable insights into detection. Hearing impairment significantly but its causal impact progression remains unclear. The review also discusses visual tactile deficits including retinal thinning changes perception, highlighting links disease progression. Focusing molecular mechanisms, explores roles amyloid-β (Aβ) accumulation tau protein pathology bidirectional relationship In summary, evidence presented conclusively supports advocating for an integrated approach understanding decline, enhance detection, implementing preventive strategies, developing therapeutic interventions This underscores significance health addressing neurodegenerative diseases, particularly
Language: Английский
Citations
5
Toxins, Journal Year: 2025, Volume and Issue: 17(1), P. 22 - 22
Published: Jan. 3, 2025
Snakebites caused by Bothrops snakes are the most prevalent in Amazon region, causing local and systemic complications. Local complications mostly represented necrosis, secondary bacterial infection compartment syndrome. There reports of long-term disabilities, but their burden is poorly investigated. This study aims to describe estimate frequency physical sensory disabilities from snakebites Manaus Region, western Brazilian region. Participants were >18-years individuals that accepted return hospital 3–12 months (average follow-up time 195 days) after discharge for neuromusculoskeletal, chronic pain assessments. Assessment disability was also performed using World Health Organization Disability Schedule 2.0 (WHODAS 2.0). Factors associated with summary WHODAS identified. Fifty participants enrolled. A 20% reported difficulty moving affected limb (20%), 23.7% walking. Limitations daily activities 26% patients. Decreased strength observed 22% range joint motion seen Chronic 48% Tactile sensibility decreased 30%, thermal 14%, painful (hypoalgesia) 12%, kinetic-postural (hypokinesthesia) 4% vibratory or abolished 16% participants. Cognition mobility domains those highest frequencies any degree disability, each 57%. The rate 59%. Age > 59 years (p = 0.02)] protection against disability. Difficulty 0.05), at < 0.01), limitations 0.01) 0.05) significantly present consists first investigation involving snakebite patients related disabilities. These findings represent important data on clinically significant neuromusculoskeletal resulting reduced quality life
Language: Английский
Citations
0
Applied Neuropsychology Adult, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 9
Published: March 25, 2025
Virtual reality (VR) has demonstrated its potential across a wide range of applications, particularly in education, healthcare, and psychology. Within neuropsychology, VR-based research on cognitive function assessment treatment is gaining momentum, leading to the development innovative neuropsychological VR paradigms. Despite advancements, limited focused using assess functions older adults. This study aimed develop an immersive cognitive-assessment tool evaluate spatial sensory-information processing The program was implemented multisensory feedback incorporating visual auditory stimuli, as well tactile gesture-based hand interactions through haptic gloves. Ten individuals (three females seven males; mean age = 65 years) participated user-experience evaluations in-depth interviews explore effectiveness areas for improvement proposed program. Survey responses were analyzed descriptive statistics user experience four categories. participants assessed exceptionally safe (5.00 points), satisfactory (4.33 well-designed (4.73 points). However, they also reported issues such discomfort during object–hand interactions, inaccurate auditory-feedback recognition, difficulty performing tactile-attention tasks. results indicate that holds considerable useful it requires further advancements sensor technology, hand-tracking algorithms, customizable interfaces.
Language: Английский
Citations
0
Journal of the American Medical Directors Association, Journal Year: 2024, Volume and Issue: 25(8), P. 105098 - 105098
Published: June 19, 2024
Language: Английский
Citations
2
Frontiers in Aging Neuroscience, Journal Year: 2024, Volume and Issue: 16
Published: July 2, 2024
Touch sensitivity generally declines with age, contributing to loss of manual dexterity and tactile function. We investigated how touch changes over the lifespan, using different tests on three body sites. used a classical test force detection sensitivity, where calibrated monofilaments were applied passively right index finger pad, forearm, cheek. In addition, at index, we an active spatial discrimination task, developed by our group. Spatial was estimated through participants' ability evaluate distance between parallel bands printed acrylic plates. Data collected from 96 healthy women, aged 20–75 years. Force deteriorated significantly age; however, no change found for forearm or Tactile cheek remained remarkably highly sensitive throughout life. There significant positive relationship index. Further, associated Our results suggest decrease in perception age yet preservation hairy skin. This opens discussion about impact daily activities upon glabrous hand skin function hairs sensitivity. highlight need new methods evaluating
Language: Английский
Citations
2
Journal of Alzheimer s Disease, Journal Year: 2024, Volume and Issue: unknown, P. 1 - 19
Published: Sept. 7, 2024
This review is an attempt to compile existing hypotheses on the mechanisms underlying initiation and progression of Alzheimer’s disease (AD), starting from sensory impairments observed in AD concluding with molecular events that are typically associated disease. These include spreading amyloid plaques tangles hyperphosphorylated tau formation Hirano Biondi bodies as well development oxidative stress. We have detailed degenerative changes occur several neuronal populations, including cholinergic neurons nucleus basalis Meynert, histaminergic tuberomammillary nucleus, serotonergic raphe nuclei, noradrenergic locus coeruleus. Furthermore, we discuss potential role iron accumulation brains subjects which served a basis for idea chelation brain may mitigate stress decelerate development. also draw attention possible sympathetic system and, more specifically, superior cervical ganglion triggering explore alternative possibility compensatory protective these support function forebrain AD.
Language: Английский
Citations
0
BMC Geriatrics, Journal Year: 2024, Volume and Issue: 24(1)
Published: Dec. 19, 2024
This study aimed to investigate the modulatory role of prefrontal cortex (PFC) activity in older adults with mild cognitive impairment (MCI) when sensory cues were removed or presented inaccurately (i.e., increased complexity) during manipulation a balance task. The research sheds light on neural regulatory mechanisms brain related control individuals MCI.
Language: Английский
Citations
0