Multimodal detection and analysis of microplastics in human thrombi from multiple anatomically distinct sites

EBioMedicine, Journal Year: 2024, Volume and Issue: 103, P. 105118 - 105118

Published: April 13, 2024

BackgroundMicroplastic (MP) pollution has emerged as a significant environmental concern worldwide. While extensive research focused on their presence in marine organisms and ecosystems, potential impact human health, particularly the circulatory system, remains understudied. This project aimed to identify quantify mass concentrations, polymer types, physical properties of MPs thrombi surgically retrieved from both arterial venous systems at three anatomically distinct sites, namely, cerebral arteries brain, coronary heart, deep veins lower extremities. Furthermore, this study investigate association between levels disease severity.MethodsThrombus samples were collected 30 patients who underwent thrombectomy procedures due ischaemic stroke (IS), myocardial infarction (MI), or vein thrombosis (DVT). Pyrolysis–gas chromatography spectrometry (Py-GC/MS) was employed concentrations MPs. Laser direct infrared (LDIR) spectroscopy scanning electron microscopy (SEM) used analyse Demographic clinical information also examined. A rigorous quality control system eliminate contamination.FindingsMPs detected by Py-GC/MS 80% (24/30) obtained with IS, MI, DVT, median 61.75 μg/g, 141.80 69.62 respectively. Among 10 target types MP polymers, polyamide 66 (PA66), polyvinyl chloride (PVC), polyethylene (PE) identified. Further analyses suggested that higher may be associated greater severity (adjusted β = 7.72, 95% CI: 2.01–13.43, p < 0.05). The level D-dimer MP-detected group significantly than MP-undetected (8.3 ± 1.5 μg/L vs 6.6 0.5 μg/L, 0.001). Additionally, LDIR analysis showed PE dominant among 15 identified MPs, accounting for 53.6% all mean diameter 35.6 μm. shapes polymers using SEM found heterogeneous.InterpretationThis presents qualitative quantitative evidence thrombotic diseases through use multimodal detection methods. Higher increased severity. Future larger sample size is urgently needed sources exposure validate observed trends study.FundingThis funded SUMC Scientific Research Initiation Grant (SRIG, No. 009-510858038), Postdoctoral (No. 202205230031-3), 2020 Li Ka Shing Foundation Cross-Disciplinary 2020LKSFG02C).

Language: Английский

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The potential of micro- and nanoplastics to exacerbate the health impacts and global burden of non-communicable diseases

Cell Reports Medicine, Journal Year: 2024, Volume and Issue: 5(6), P. 101581 - 101581

Published: May 22, 2024

Non-communicable diseases (NCD) constitute one of the highest burdens disease globally and are associated with inflammatory responses in target organs. There is increasing evidence significant human exposure to micro- nanoplastics (MnPs). This review environmental MnP health impacts indicates that particles, directly indirectly through their leachates, may exacerbate inflammation. Meanwhile, persistent inflammation NCDs gastrointestinal respiratory systems potentially increases uptake, thus influencing access distal Consequently, a future increase augments risk severity NCDs. critical need for an integrated one-health approach research assessing drivers bidirectional links Assessing these risks requires interdisciplinary efforts identify link organismal uptake studies impacted mechanisms outcomes.

Language: Английский

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Assessing microplastic and nanoplastic contamination in bird lungs: evidence of ecological risks and bioindicator potential

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 487, P. 137274 - 137274

Published: Jan. 17, 2025

Language: Английский

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Soil and water pollution and cardiovascular disease

Nature Reviews Cardiology, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 25, 2024

Language: Английский

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Review on personal protective equipment: Emerging concerns in micro(nano)plastic pollution and strategies for addressing environmental challenges

Environmental Research, Journal Year: 2024, Volume and Issue: 257, P. 119345 - 119345

Published: June 6, 2024

Language: Английский

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Unveiling the impacts of microplastic pollution on soil health: A comprehensive review

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 951, P. 175643 - 175643

Published: Aug. 22, 2024

Language: Английский

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Nanoplastic at environmentally relevant concentrations induces toxicity across multiple generations associated with inhibition in germline G protein-coupled receptor CED-1 in Caenorhabditis elegans

Chemosphere, Journal Year: 2024, Volume and Issue: 364, P. 143011 - 143011

Published: Aug. 3, 2024

Language: Английский

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Polyethylene Micro/Nanoplastics Exposure Induces Epithelial–Mesenchymal Transition in Human Bronchial and Alveolar Epithelial Cells

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(18), P. 10168 - 10168

Published: Sept. 22, 2024

Micro/nanoplastics (MNPs), which are widely spread in the environment, have gained attention because of their ability to enter human body mainly through ingestion, inhalation, and skin contact, thus representing a serious health threat. Several studies reported presence MNPs lung tissue potential role MNP inhalation triggering fibrosis tumorigenesis. However, there is paucity knowledge regarding cellular response composed polyethylene (PE), one most common plastic pollutants biosphere. In this study, we investigated effects low/high concentrations PE on respiratory epithelial cell viability migration/invasion abilities, using MTT, scratch, transwell assays. Morphological molecular changes were assessed via immunofluorescence, Western blot, qRT-PCR. We demonstrated that acute exposure does not induce toxicity. Instead, cells displayed visible morphological also involving actin cytoskeleton reorganization. Our data underlined epithelial–mesenchymal transition (EMT) process. Moreover, remarkable increase migration was noticed, absence significant alteration cell’s invasive capacity. The present study highlights impact epithelium, suggesting possible carcinogenesis.

Language: Английский

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Single‐use materials and poorly recycled waste in intensive care: An argument for improving sustainability

Nursing in Critical Care, Journal Year: 2025, Volume and Issue: 30(1), P. 68 - 70

Published: Jan. 1, 2025

Intensive care unit (ICU) clinical items and packaging made from plastic, paper other (mixed) materials have a significant environmental impact.1 These products are energy-intensive generate large carbon footprint high levels of air pollution due to raw extraction, manufacture, distribution, use disposal. Paper, glass metal (steel, aluminium, etc.) pose less long-term threat than plastics because they can be relatively easily recycled almost indefinitely. This critical commentary offers scientist perspective regarding the over-reliance on single-use plastic poor recycling in ICU settings enable nurses their multi-disciplinary colleagues understand composition health better. With improved knowledge about making up used daily ICUs, will more equipped contribute sustainable procurement waste management, which important aspects national strategies become net zero system.2 In United Kingdom, there is also now 'Design for Life roadmap' providing expectations radically reduce maximize reuse, remanufacture recycling.3 Plastics wonderfully malleable adaptable materials, with physics term 'plastic' referring material's ability extensively deformed before breakage. The assumed cover single type material, although collective includes 200 distinct chemical compounds. Traditional or conventional correctly referred as petrochemical-derived (PDP) wholly part derived oil natural gas. polymers linked units 'string-like' entities varying molecular size (between tens thousands many millions). bulk functionalized by incorporating additives, such endocrine-disrupting plasticisers preservatives, leach material. favoured material cheap, versatile, shaped, accessible chemically inert. PDPs offer physical protection against water, air, impact, distortion temperature. Their inertness "double-edged sword" that it lead persistence. desirable properties include water repellence, mechanical toughness, rigidity protection. comes product types—consider how daily, intravenous fluid bags tubing, incontinence pads, syringes, sharps, medicine containers, personal protective equipment (PPE), catheters supplies ventilation, nutrition, suctioning procedural packs (and list could go on). Each item its contain different showing complexity products, most considerable amounts plastics. For example, syringe needle consist four types (polyethylene, PVC, polypropylene, cyclic olefin), rubber, paper, stainless steel silicone lubricant across device, container wrapper. Plastic accounts amount waste, majority plastic; however, cannot same purposes very well. Consequently, any only up-cycled repurposed. Typically, this involves embedding throughout cement construction industries combination molten sawdust, cotton fibre sand make composite paving, fencing furniture. Upon recycling, undergo thermally-induced chain scission, consequently degenerating quality. Other issues associated SUPs supply finite resource lack longer-term sustainability. addition, incineration liberates CO2 greenhouse gases (GHGs), exacerbating climate change. landfill-disposal, compostable substances liberate methane (CH4), nylon food nitrous oxide (N2O) related oxides, NOx gases. three specific constitutes approximately 80% all GHG emissions, while two account 17%. ascribed global warming potential (GWP) value (over 100 years persistence) 1.0, CH4 N2O GWP values 32 times 280 higher, respectively. means 1 gram times, influential CO2. Nitrous has impact destroying atmospheric ozone, protects Earth harmful ultraviolet light.4 Some recovery initial required energy obtained processes (incineration some fraction generated heat). However, lies outside circular economy generates GHGs cause rise baseline GWP. Another strategy involve sequestering storage but again, short-sighted view short-term fix. Similarly, crude treatment give modified inferior properties. Recycling policy 3Rs (reduce, recycle) number new needed virgin Currently, metals fare well during recycling. Polyester (PET) multiple without losing valued properties.5 PET still limitations, an estimated maximum seven cycles becomes unsuitable (poor unworkable). degrade open seas oxygen-related oxidative change action. embrittling makes them subject fragmentation debriding, forming particles sizes 5 mm width, microplastics. Very small versions microplastics, called nano-particulates, absorbed marine flora fauna and, therefore, indirectly into human bodies via digestive tract.6 New evidence points disruptive action these nanoplastics fertility, endocrine system, immune hepatotoxicity, nerve malfunction oncogenesis.7 Given persistence environment (air, land sea) 350–650 years, accumulating soil, ocean floor represent real ecosystems humankind alike. Alternatives range short-lived (1–2 years) mixed often bioplastics biopolymer composites. commodities agricultural wastes, including sustainably sourced starting cellulose, starch, glycerol, bio-detergents various plant oils waxes. Plant waxes water-repellent. candidates pressed dried highly-compressed wood pulp, glassine heated starches microbial fermentation, polylactic acid (PLA)—lactic being present yoghurt. PLA cheapest expensive mass-produced weight-used basis at £1.6/kg compared £3.2/kg biopolymers; costs £1.0–1.1/kg PDPs, creating financial barrier.5 Bioplastics impacts when considering full life cycle8 use, pesticides, consumption, gas biodegradability recyclability, research resolve indicates promise potentially role replacing traditional plastics.9 alternatives current practice re-engineering thick walling films, bottles closures using supporting ridges, struts baffles "light weighting" redesign adjust weight produced.10 Substitution SUP polyethylene apron forms PPE waxed rinsed, sterilized another possibility. waxy character, calendar-rolled (called glassine) excellent replacement film. converted back pulp after prolonged soaking hot re-casting. degrades buried matter rather centuries PDPs. Medical trays, holders, vessels catering recyclable paper. All departments, resource-intensive areas like produce volumes must reconsider plastic-based currently find alternative solutions. Research industry collaborate establish abundant, cheap Where need should identical near-identical those yet universally collected similar use. Collection processing ensure mass careful handling disposal limit entry environment. Preventing landfill-disposed entering rivers, lakes, coastal deep-sea avoid There needs urgent, collective, powerful drive replace items, reusable increased required. As section workforce, calls out engage science, design, management sustainability researchers provide valuable nursing shift towards environmentally supplies. Data sharing not applicable article no data were created analyzed study.

Language: Английский

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Exposure to polyethylene terephthalate micro(nano)plastics exacerbates inflammation and fibrosis after myocardial infarction by reprogramming the gut and lung microbiota and metabolome

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 488, P. 137410 - 137410

Published: Jan. 30, 2025

Language: Английский

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