Free Radical Biology and Medicine, Journal Year: 2025, Volume and Issue: unknown
Published: May 1, 2025
Language: Английский
Molecular Cancer, Journal Year: 2025, Volume and Issue: 24(1)
Published: Jan. 24, 2025
Microplastics, as an emerging environmental pollutant, have received widespread attention for their potential impact on ecosystems and human health. Microplastics are defined plastic particles less than 5 millimeters in diameter can be categorized primary secondary microplastics. Primary microplastics usually originate directly from industrial production, while formed by the degradation of larger items. capable triggering cytotoxicity chronic inflammation, may promote cancer through mechanisms such pro-inflammatory responses, oxidative stress endocrine disruption. In addition, improved bring new perspectives to therapy, studies drug carriers underway, showing high targeting bioavailability. Although current suggest association between certain cancers (e.g., lung, liver, breast cancers), long-term effects specific still need studied. This review aimed at exploring carcinogenicity promising applications therapy provides important directions future research emphasizes multidisciplinary collaboration address this global health challenge.
Language: Английский
Citations
3
ACS Nano, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 27, 2025
Although considered an "eco-friendly" biodegradable plastic, polylactic acid (PLA) microplastic (PLA-MP) poses a growing concern for human health, yet its effects on male reproductive function remain underexplored. This study investigated the toxicity of PLA in mice and potential mechanisms. To this end, our vivo vitro experiments demonstrated that after degradation digestive system, significant number PLA-MP-derived nanoparticles could penetrate blood–testis barrier (BTB) localize within spermatogenic microenvironment. Mice exposed to PLA-MPs long time exhibited toxicity, evidenced by decreased sperm concentration motility, increased deformity rates, disrupted sex hormone levels. Further analysis revealed impaired BTB, induced mitochondrial dysfunction testes, triggered oxidative stress through excessive ROS production from mitochondria, leading further testicular damage. Notably, nanoplastics internalized sheath structure sperm, causing dose-dependent impairments function. Transcriptome analyses indicated spermatogenesis inhibiting expression key mRNA involved process. Collectively, findings highlight toxic effect damaging BTB impairing function, which provides insights into toxicological implications microplastics mammalian fertility.
Language: Английский
Citations
3
The Science of The Total Environment, Journal Year: 2025, Volume and Issue: 968, P. 178882 - 178882
Published: Feb. 22, 2025
Language: Английский
Citations
2
Frontiers in Cell and Developmental Biology, Journal Year: 2025, Volume and Issue: 13
Published: Feb. 28, 2025
Introduction Microplastics and nanoplastics are prevalent environmental contaminants. Recent reports indicate that polystyrene nanoparticles may adversely impact male reproductive health. This study aims to examine the effects of exposure on sperm metabolism development pre-implantation embryos. Methods In this study, C57BL/6 mice were orally gavage-administered (60 nm, 20 mg/kg/day) for 35 days assess their reproduction early embryonic development. Experiments included testicular transcriptome analysis, metabolomics, motility fertilization assays, ROS detection, RNA sequencing 2-cell embryos, revealing adverse embryo Results The results revealed oral gavage induced a pronounced immune-inflammatory response in tissue, reduced motility, significantly lowered rate. Notably, from treated exhibited substantial metabolic disruptions, affecting key pathways, including glycerophospholipid biosynthesis DNA repair. After fertilization, embryos at stage suffered damage apoptotic repair subsequently impairing Discussion conclusion, demonstrated administration affects function, resulting abnormalities alterations associated gene expression profiles. These findings offer essential scientific insights future research into sperm-mediated transgenerational
Language: Английский
Citations
1
Journal of Hazardous Materials Advances, Journal Year: 2025, Volume and Issue: unknown, P. 100667 - 100667
Published: March 1, 2025
Language: Английский
Citations
0
Environmental Pollution, Journal Year: 2025, Volume and Issue: 375, P. 126335 - 126335
Published: April 29, 2025
Language: Английский
Citations
0
Frontiers in Aging, Journal Year: 2025, Volume and Issue: 6
Published: May 21, 2025
As the fertility risks for older males such as infertility and reduced success rates are on rise, an increasing number of individuals turning to Assisted Reproductive Technology (ART) have offspring. However, influence paternal age pregnancy outcomes in ART cycles remains ambiguous. Here, we analyzed sperm quality 6,805 samples DNA fragmentation index (DFI) 1,253 from Chinese aged 20–63 years old. Our findings demonstrated that volume, progressive motility, total motility significantly decline, while DFI increases advances. Additionally, by studying 1,205 cases undergoing treatment, discovered male do not exhibit a pronounced impact outcomes. study has disclosed inversely correlated with age. data further suggest ages affect outcomes, which should offer instructive references practice involving males.
Language: Английский
Citations
0
Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16
Published: May 21, 2025
Semen quality is a key factor in male fertility, but defining normal reference values for semen parameters remain challenging. Over the past four decades, several authors have reported noticeable decline sperm parameters, raising concerns about reproductive health. While exact causes unclear, potential contributors include environmental pollution, endocrine disruptor chemicals (EDCs) and oxidative stress, with latter becoming growing concern. Environmental changes increased exposure to EDCs, such as pesticides, herbicides, bisphenol A (BPA), phthalates, polychlorinated biphenyls (PCBs), heavy metals, are believed contribute significantly quality. These impact individuals from prenatal life through adulthood, potentially leading long-term consequences. Overall, this review explores relationship between toxicants, including volatile organic compounds, well stress reduced fertility. substantial body of research has found associations these exposures adverse fertility outcomes, some studies no significant associations. The primary objective provide deeper understanding mechanisms on testicular function spermatogenesis. It also examines broader evidence its implications overall outcomes humans. By doing so, will shed light public health pollutants their health, emphasizing need further critical area.
Language: Английский
Citations
0
Archives of Toxicology, Journal Year: 2025, Volume and Issue: unknown
Published: Feb. 3, 2025
Language: Английский
Citations
0
Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: unknown, P. 138133 - 138133
Published: April 1, 2025
Language: Английский
Citations
0