Biogenic synthesized CuO nanoparticles and 5-fluorouracil loaded anticancer gel for HeLa cervical cancer cells DOI Creative Commons
Gouranga Dutta, Santhosh Kumar Chinnaiyan, Thirunavukkarasu Palaniyandi

et al.

Discover Nano, Journal Year: 2024, Volume and Issue: 19(1)

Published: Dec. 27, 2024

Abstract Cervical cancer remains a significant health challenge in developing countries are high due to low HPV vaccination rates, delayed diagnosis, and restricted healthcare access. Metal nanomaterials, such as copper oxide (CuO) nanoparticles (NPs), have shown promise therapy their ability induce apoptosis. 5-Fluorouracil (5-Fu) enhances the cytotoxic effect against cervical cancer, working synergistically with CuO NPs maximize therapeutic impact while potentially reducing 5-Fu's systemic side effects. This study explores synergistic potential of green-synthesized combined 5-Fu gel formulation for targeted anticancer activity HeLa cells. were synthesized using Trichosanthes dioica dried seeds extract incorporated into pectin-xanthan gum-based gel. The exhibited zeta −23.7 mV, particle size approximately 26 nm, spherical morphology. Characterization studies, including FTIR, viscosity, spreadability, pH, stability assessments, confirmed gel's suitability vaginal delivery. In-vitro drug release showed xanthan gum extended up 8 h. MTT assay revealed PXFCu6 IC 50 at 11.82 ± 0.22 μg/mL, significantly more cells, being 3.62 times potent than (IC : 42.8 0.24 μg/mL) 1.63 alone 19.3 0.49 μg/mL). antibacterial no inhibition plain gel, but T. -mediated 22.35 4.9 mm. had 52.05 1.37 mm Escherichia coli growth. better 4 °C, maintaining release, unlike 25 °C where mild degradation occurred. research highlights NPs-5-Fu novel, effective strategy treatment. Graphical abstract

Language: Английский

Knowledge map of programmed cell death in esophageal cancer: a bibliometric analysis DOI Creative Commons

Rulin Li,

Yanchun Yang,

Yang Gao

et al.

Discover Oncology, Journal Year: 2025, Volume and Issue: 16(1)

Published: April 24, 2025

This study aimed to delineate the evolving knowledge structure of programmed cell death in esophageal cancer and identify key thematic trends, influential collaborations, emerging areas for future research. A bibliometric approach was applied 2677 publications retrieved from Web Science Core Collection (2000-2024). Three complementary tools-CiteSpace, VOSviewer, bibliometrix-were employed visualize co-citation networks, detect citation bursts, map collaborative patterns among authors, institutions, countries. Inclusion criteria focused on articles reviews that addressed conjunction with apoptosis, necroptosis, pyroptosis, ferroptosis, autophagy, or related pathways. Publication outputs grew markedly, reflecting a shift early investigations basic apoptotic mechanisms broader explorations ferroptosis. China led publication volume citations, driven by substantial governmental funding large clinical cohorts. The United States Japan also contributed significantly, forming international research networks spanned Asia Europe. Leading particularly Zhengzhou University, demonstrated extensive collaborations. Journals such as Oncology Letters Reports were prominent outlets new findings, while highly cited references highlighted hypoxia, immune checkpoint blockade, gene-editing strategies. Keyword analyses revealed ascendance immuno-oncology, network pharmacology, translational applications targeting multiple regulated Bibliometric evidence underscores rapid expansion multidisciplinary integrates diverse pathways cancer. Continued leveraging advanced genomics immunologic strategies, are poised accelerate breakthroughs enable more personalized, effective therapies.

Language: Английский

Citations

0
Biogenic synthesized CuO nanoparticles and 5-fluorouracil loaded anticancer gel for HeLa cervical cancer cells DOI Creative Commons
Gouranga Dutta, Santhosh Kumar Chinnaiyan, Thirunavukkarasu Palaniyandi

et al.

Discover Nano, Journal Year: 2024, Volume and Issue: 19(1)

Published: Dec. 27, 2024

Abstract Cervical cancer remains a significant health challenge in developing countries are high due to low HPV vaccination rates, delayed diagnosis, and restricted healthcare access. Metal nanomaterials, such as copper oxide (CuO) nanoparticles (NPs), have shown promise therapy their ability induce apoptosis. 5-Fluorouracil (5-Fu) enhances the cytotoxic effect against cervical cancer, working synergistically with CuO NPs maximize therapeutic impact while potentially reducing 5-Fu's systemic side effects. This study explores synergistic potential of green-synthesized combined 5-Fu gel formulation for targeted anticancer activity HeLa cells. were synthesized using Trichosanthes dioica dried seeds extract incorporated into pectin-xanthan gum-based gel. The exhibited zeta −23.7 mV, particle size approximately 26 nm, spherical morphology. Characterization studies, including FTIR, viscosity, spreadability, pH, stability assessments, confirmed gel's suitability vaginal delivery. In-vitro drug release showed xanthan gum extended up 8 h. MTT assay revealed PXFCu6 IC 50 at 11.82 ± 0.22 μg/mL, significantly more cells, being 3.62 times potent than (IC : 42.8 0.24 μg/mL) 1.63 alone 19.3 0.49 μg/mL). antibacterial no inhibition plain gel, but T. -mediated 22.35 4.9 mm. had 52.05 1.37 mm Escherichia coli growth. better 4 °C, maintaining release, unlike 25 °C where mild degradation occurred. research highlights NPs-5-Fu novel, effective strategy treatment. Graphical abstract

Language: Английский

Citations

1