Admixture as a source for HLA variation in Neolithic European farming communities DOI Creative Commons
Nicolas Antonio da Silva, Onur Ӧzer, Magdalena Haller

et al.

Genome biology, Journal Year: 2025, Volume and Issue: 26(1)

Published: Feb. 28, 2025

Abstract Background The northern European Neolithic is characterized by two major demographic events: immigration of early farmers from Anatolia at 7500 years before present, and their admixture with local western hunter-gatherers forming late farmers, around 6200 present. influence this event on variation in the immune-relevant human leukocyte antigen (HLA) region understudied. Results We analyzed genome-wide data 125 individuals seven archeological farmer sites located present-day Germany. group studied here associated Wartberg culture, 5500–4800 note that resulted sex-biased male hunter-gatherers. In addition, we observe Y-chromosome haplogroup I as dominant lineage site-specific sub-lineages. analyze true HLA genotypes 135 individuals, majority which were produced study. significant shifts allele frequencies to likely due Especially for haplotype DQB1*04:01-DRB1*08:01, there evidence a hunter-gatherer origin. diversity increased farmers. However, it considerably lower than modern populations. Conclusions Both exhibit relatively narrow spectrum compared today. This coincides sparse traces pathogen DNA, potentially indicating pressure time.

Language: Английский

Admixture as a source for HLA variation in Neolithic European farming communities DOI Creative Commons
Nicolas Antonio da Silva, Onur Ӧzer, Magdalena Haller

et al.

Genome biology, Journal Year: 2025, Volume and Issue: 26(1)

Published: Feb. 28, 2025

Abstract Background The northern European Neolithic is characterized by two major demographic events: immigration of early farmers from Anatolia at 7500 years before present, and their admixture with local western hunter-gatherers forming late farmers, around 6200 present. influence this event on variation in the immune-relevant human leukocyte antigen (HLA) region understudied. Results We analyzed genome-wide data 125 individuals seven archeological farmer sites located present-day Germany. group studied here associated Wartberg culture, 5500–4800 note that resulted sex-biased male hunter-gatherers. In addition, we observe Y-chromosome haplogroup I as dominant lineage site-specific sub-lineages. analyze true HLA genotypes 135 individuals, majority which were produced study. significant shifts allele frequencies to likely due Especially for haplotype DQB1*04:01-DRB1*08:01, there evidence a hunter-gatherer origin. diversity increased farmers. However, it considerably lower than modern populations. Conclusions Both exhibit relatively narrow spectrum compared today. This coincides sparse traces pathogen DNA, potentially indicating pressure time.

Language: Английский

Citations

0