The Role of Physical Activity on Some Biochemical Parameters in Cancer Treatment DOI
Egemen Dere

Doğu Karadeniz Sağlık Bilimleri Dergisi, Journal Year: 2024, Volume and Issue: 3(1), P. 10 - 24

Published: March 30, 2024

Cancer poses a serious public health problem. Recent studies underscore the crucial role of exercise in enhancing quality life for cancer patients, both during and after treatment, its potential positive impact on treatment outcomes. This article assesses importance physical activity context cancer, drawing current data. is long-term process that includes different methods strategies. Crafting plan hinges factors such as patient's age, overall health, specific type, staging. The main include chemotherapy, radiotherapy, immunotherapy, surgical procedures, targeted therapies, hormone therapy stem cell transplantation. One ways to reduce side effects occur patients treated with one or more these do aerobic resistance exercises. Research emphasizes increasing treatment. period characterized by increased emotional stress. Regular has proven benefits. Exercise stimulates release endorphins, reduces depression, anxiety promotes better sleep quality. Furthermore, it serves alleviate fatigue, muscle loss, weight gain, diminished bone density. Additionally, regular contributes fortifying immune system, against infections. Notably, research highlights women breast exhibit reduced risk recurrence when they incorporate into their lives exerts significant influence enzyme activities, potentially leading alterations metabolic processes. Enzyme activities may either rise fall based metabolism. been shown boost antioxidant enzymes while simultaneously diminishing oxidative effect holds particular considering stress known facilitate growth dissemination cells In conclusion, can be said exercising increasingly understood. However, since each unique, need individually tailored monitored experts.

Language: Английский

Harms of exercise training in patients with cancer undergoing systemic treatment: a systematic review and meta-analysis of published and unpublished controlled trials DOI Creative Commons
Simon Nørskov Thomsen, Ian M. Lahart,

Laura M. Thomsen

et al.

EClinicalMedicine, Journal Year: 2023, Volume and Issue: 59, P. 101937 - 101937

Published: April 6, 2023

Exercise is recommended for people with cancer. The aim of this study was to evaluate the harms exercise in patients cancer undergoing systemic treatment.

Language: Английский

Citations

35
The efficacy and safety of exercise regimens to mitigate chemotherapy cardiotoxicity: a systematic review and meta-analysis of randomized controlled trials DOI Creative Commons
Ahmed Mazen Amin, Yehya Khlidj, Mohamed Abuelazm

et al.

Cardio-Oncology, Journal Year: 2024, Volume and Issue: 10(1)

Published: Feb. 23, 2024

Abstract Background Cardiotoxicity is one of the most common adverse events chemotherapy. Physical exercise was shown to be cardioprotective. We aim estimate efficacy and safety in cancer patients receiving cardiotoxic Methods conducted a systematic review meta-analysis randomized controlled trials (RCTs), which were retrieved by systematically searching PubMed, Web Science, SCOPUS, Cochrane, Clinical Trials.gov, MedRxiv through July 17th, 2023. used RevMan V. 5.4 pool dichotomous data using risk ratio (RR) continuous mean difference (MD), with 95% confidence interval (CI). PROSPERO ID: CRD42023460902. Results included thirteen RCTs total 952 patients. Exercise significantly increased VO 2 peak (MD: 1.95 CI [0.59, 3.32], P = 0.005). However, there no significant effect regarding left ventricular ejection fraction, global longitudinal strain, cardiac output, stroke volume, end-diastolic end-systolic E/A ratio, resting heart rate, systolic blood pressure, diastolic pressure. Also, any (AEs) (RR: 4.44 [0.47, 41.56], 0.19), AEs leading withdrawal 2.87 [0.79, 10.43], 0.11), serious 3.00 [0.14, 65.90], 0.49), or all-cause mortality 0.25 [0.03, 2.22], 0.21). Conclusion associated between usual care echocardiographic outcomes.

Language: Английский

Citations

9
The Physical Activity and Cancer Control (PACC) framework: update on the evidence, guidelines, and future research priorities DOI Creative Commons
Lin Yang, Kerry S. Courneya, Christine M. Friedenreich

et al.

British Journal of Cancer, Journal Year: 2024, Volume and Issue: 131(6), P. 957 - 969

Published: June 27, 2024

We proposed the Physical Activity and Cancer Control (PACC) framework in 2007 to help organise, focus, stimulate research on physical activity eight cancer control categories: prevention, detection, treatment preparation/coping, coping/effectiveness, recovery/rehabilitation, disease prevention/health promotion, palliation, survival. This perspective paper provides a high-level overview of scientific advances across categories, summarises current guidelines, updates PACC framework, identifies remaining emerging knowledge gaps, future directions. Many have been made that are reflected updated guidelines for six categories apart from detection palliation. Nevertheless, minimal optimal type, dose, timing remain unknown, especially understudied population subgroups defined by age, race/ethnicity, resource level regions/countries. To achieve full benefit control, should use innovative study designs include diverse at-risk populations sites. Additionally, effective behaviour change strategies needed increase levels implementation science accelerate translation evidence generation into practical, real-world interventions.

Language: Английский

Citations

9
Feasibility of a comprehensive supervised exercise program during and after treatment of head and neck cancer: a mixed-methods study DOI
Kaat Van Aperen, An De Groef, Thierry Troosters

et al.

Supportive Care in Cancer, Journal Year: 2025, Volume and Issue: 33(2)

Published: Jan. 16, 2025

Language: Английский

Citations

0
Physical exercises can alleviate harmine toxicity in the case of oncological treatments DOI

Bogdan-Alexandru Hagiu

Medical Hypotheses, Journal Year: 2025, Volume and Issue: unknown, P. 111579 - 111579

Published: Feb. 1, 2025

Language: Английский

Citations

0
Effectiveness of exercise interventions on functional outcomes in frail adults with a previous or current diagnosis of cancer: a systematic review and meta-analysis DOI

Maya El-Zahed,

Lou-Anne Laura Carsault,

M Grande

et al.

Journal of Cancer Survivorship, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

Language: Английский

Citations

0
Feasibility, safety, and adherence of home-based exercise interventions in people diagnosed with cancer: a systematic review DOI Creative Commons
Jing Jing Su, Petr Winnige,

Katerina Chamradova

et al.

Journal of Cancer Survivorship, Journal Year: 2025, Volume and Issue: unknown

Published: March 22, 2025

Abstract Purpose This systematic review aims to evaluate the feasibility, safety, and adherence of home-based exercise interventions in people diagnosed with cancer. The primary research question is: Are safe feasible for cancer? Methods A comprehensive search databases including PubMed, EMBASE, Cochrane Library was conducted January 2025, focusing on randomized controlled trials (RCTs) that involved Studies were included if they reported health-related outcomes. Physiotherapy Evidence Database (PEDro) scale used assess study quality risk bias. Adverse events categorized by severity, feasibility which determined based recruitment, withdrawal, rates. Results From 127 eligible studies involving 10,562 participants, found are generally safe, less than 3.2% participants experiencing exercise-related adverse events, most minor. Feasibility supported an average recruitment rate 50.1%, calculated as proportion who consented participate across studies. Additionally, a withdrawal 13.7%, 76.2%. However, significant variability these rates observed studies, highlighting challenges maintaining participant engagement. Conclusions Home-based cancer, minor being common. there is need standardized protocols reporting better strategies improve adherence. Implications cancer survivors These findings support integration into standard care, offering practical option enhancing health well-being survivors. successful implementation programs may require additional from professionals within care or community settings ensure appropriate guidance Personalized programs, developed qualified such physiotherapists clinical physiologists, improved standards essential optimizing interventions.

Language: Английский

Citations

0
Exploring the impact of physical exercise regimens on health-related quality of life following oesophageal or gastric cancer surgery: a systematic review and meta-analysis of randomized controlled trials DOI Creative Commons
Kenneth Färnqvist,

Kalle Mälberg,

Asif Johar

et al.

BMC Sports Science Medicine and Rehabilitation, Journal Year: 2025, Volume and Issue: 17(1)

Published: March 29, 2025

To assess the effectiveness and adverse events of postoperative physical exercise on health-related quality life (HRQL) in patients who have undergone surgery for oesophageal or gastric cancer. We conducted a systematic review meta-analysis reported it according to preferred reporting items reviews meta-analyses. (PRISMA) guidelines. Randomised controlled trials (RCT) that investigated HRQL factors following interventions undergoing cancer were included. Studies including participants had oesophagectomy gastrectomy cancer, either sex 18 years older Participants with other cancers excluded. Medline, Embase, CINAHL, Cochrane Library, PEDro, trial registries searched studies from inception until February 2025. Results synthesised using Two independent reviewers assessed risk bias tool 2.0, grading recommendations assessment, development evaluation (GRADE) was used evaluate overall certainty evidence. PROSPERO ID CRD42022358493. Three enrolling 284 included, which two at high one some concerns. The global score European Organisation Research Rreatment Cancer (EORTC) questionnaire QLQ-C30 all included studies. ranges 0 100, higher scores indicating better HRQL. Physical therapy no discernible impact compared control group (mean difference 0.77 [95% CI -4.36, 5.90]. However, evidence very low, should be considered when interpreting results as they can differ substantially true effects. found significant lack information about effects post-surgery standard care Based current low evidence, safety treated is uncertain. investigating exercise.

Language: Английский

Citations

0
Dropout from exercise trials among cancer survivors—An individual patient data meta‐analysis from the POLARIS study DOI Creative Commons
Benedikte Western, Andréas Ivarsson, Ingvild Vistad

et al.

Scandinavian Journal of Medicine and Science in Sports, Journal Year: 2024, Volume and Issue: 34(2)

Published: Feb. 1, 2024

Abstract Introduction The number of randomized controlled trials (RCTs) investigating the effects exercise among cancer survivors has increased in recent years; however, participants dropping out are rarely described. objective present study was to assess which combinations participant and program characteristics were associated with dropout from arms RCTs survivors. Methods This used data collected Predicting OptimaL cAncer RehabIlitation Supportive care (POLARIS) study, an international database Thirty‐four trials, a total 2467 patients without metastatic disease arm included. Harmonized studies included pre posttest, classified as dropouts when missing all assessments at post‐intervention test. Subgroups identified conditional inference tree. Results Overall, 9.6% dropped out. Five subgroups tree based on four significant associations dropout. Most observed for BMI >28.4 kg/m 2 , performing supervised resistance or unsupervised mixed (19.8% dropout) had low‐medium education performed aerobic (13.5%). lowest found high (5.1%), ≤28.4 exercising during (5.2%) post (9.5%) treatment. Conclusions There several systematic differences between completing possibly affecting external validity effects.

Language: Английский

Citations

3
First, do no harm: a call to action to improve the evaluation of harms in clinical exercise research DOI
Simon Nørskov Thomsen, Alejandro Lucía, Rosalind R. Spence

et al.

British Journal of Sports Medicine, Journal Year: 2024, Volume and Issue: 58(12), P. 636 - 638

Published: April 18, 2024

Language: Английский

Citations

3