Early childhood developmental concerns following SARS-CoV-2 infection and COVID-19 vaccination during pregnancy: a Scottish population-level retrospective cohort study
The Lancet Child & Adolescent Health,
Journal Year:
2025,
Volume and Issue:
9(3), P. 162 - 171
Published: Feb. 18, 2025
Understanding
the
effects
of
SARS-CoV-2
infection
and
COVID-19
vaccination
during
pregnancy
can
help
inform
clinical
guidance
tackle
vaccine
hesitancy.
We
examined
relationships
between
pregnancy,
early
child
developmental
concerns
in
children
aged
13-15
months
Scotland.
created
a
large,
population-level
linked
administrative
health
dataset,
combining
Pregnancy
Scotland
(COPS)
dataset
with
age
month
review
data
other
datasets.
included
estimated
to
have
been
conceived
after
May
18,
2020,
born
before
Sept
30,
2021,
their
mothers.
used
logistic
regression
modelling
investigate
associations
(ie,
parent
or
caregiver
visitor-identified
regarding
speech-language-communication,
problem
solving,
gross
motor,
personal-social,
emotional-behavioural
development)
measured
routine
reviews
at
months,
including
adjustment
for
confounders
covariates.
A
total
24
919
child-mother
pairs
(12
752
[51·2%]
male
children;
12
167
[48·8%]
female
children)
were
included.
1631
(6·5%)
prenatally
exposed
4943
(19·8%)
vaccination.
found
no
concerns.
After
confounder
covariate
adjustment,
was
associated
reduced
odds
solving
(odds
ratio
0·78
[95%
CI
0·64-0·95]),
personal-social
(0·76
[0·61-0·95]),
(0·67
[0·48-0·92])
development,
but
had
infections
do
not
appear
be
childhood
concerns,
vaccinations
safe
from
perspective
As
some
become
apparent
until
are
older
than
future
research
should
continue
monitor
outcomes
as
grow
develop.
Economic
Social
Research
Council.
Language: Английский
In need of robust evidence of non-association of pregestational and early pregnancy SARS-CoV-2 infections with congenital anomalies
EClinicalMedicine,
Journal Year:
2024,
Volume and Issue:
74, P. 102729 - 102729
Published: July 13, 2024
SARS-CoV-2
infection
during
pregestational
and
early
pregnancy
periods
has
an
unclear
impact
on
fetal
development.
Although
vertical
transmission
is
rare,
potential
effects
the
developing
brain
are
plausible.
However,
robust
evidence
linking
maternal
to
congenital
anomalies
limited
due
inadequate
tracking
of
history
methodological
flaws
in
published
studies.
This
further
complicated
by
limitations,
such
as
restricted
testing
access
undiagnosed
infections,
particularly
low-
middle-income
countries.
Most
data
focus
hospitalized
women
near
term,
lacking
information
first-
second-trimester
infections.
Thus,
accurate
assessment
COVID-19
essential.
It
should
however
be
emphasised
that
we
have
vaccination
against
before
or
not
associated
with
malformations,
ruling
out
any
role
vaccines
these
increased
rates
abnormalities.
viewpoint
discusses
findings
from
surveillance
registries,
highlights
study
offers
research
recommendations
inform
clinical
guidelines
public
health
strategies,
aiming
mitigate
viral
infections
neurodevelopment.
Language: Английский