Impact of long COVID on health-related quality-of-life: an OpenSAFELY population cohort study using patient-reported outcome measures (OpenPROMPT)

The Lancet Regional Health - Europe, Journal Year: 2024, Volume and Issue: 40, P. 100908 - 100908

Published: April 24, 2024

Language: Английский

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Healthcare utilisation in people with long COVID: an OpenSAFELY cohort study

BMC Medicine, Journal Year: 2024, Volume and Issue: 22(1)

Published: June 20, 2024

Abstract Background Long COVID potentially increases healthcare utilisation and costs. However, its impact on the NHS remains to be determined. Methods This study aims assess of individuals with long COVID. With approval England, we conducted a matched cohort using primary secondary care data via OpenSAFELY, platform for analysing anonymous electronic health records. The exposure group, defined by diagnostic codes, was five comparators without between Nov 2020 Jan 2023. We compared their total from GP consultations, prescriptions, hospital admissions, A&E visits, outpatient appointments. Healthcare costs were evaluated two-part model adjusting covariates. Using difference-in-difference model, also after pre-pandemic Results identified 52,988 diagnosis, 264,867 diagnosis. In 12 months post-diagnosis, there strong evidence that those more likely use resources (OR: 8.29, 95% CI: 7.74–8.87), have 49% (RR: 1.49, 1.48–1.51). Our estimated group had 30 visits per year (predicted mean: 29.23, 28.58–29.92), 16 in comparator mean visits: 16.04, 15.73–16.36). Individuals non-zero expenditures (OR = 7.66, CI 7.20–8.15), being 44% higher than (cost ratio 1.44, 1.39–1.50). approximately £2500 person cost: £2562.50, £2335.60–£2819.22), £1500 £1527.43, £1404.33–1664.45). Historically, utilised frequently, but average increased diagnosed COVID, group. Conclusions Public policies should allocate towards preventing, treating, supporting

Language: Английский

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Factors affecting the impact of COVID-19 vaccination on post COVID-19 conditions among adults: A systematic literature review

Human Vaccines & Immunotherapeutics, Journal Year: 2025, Volume and Issue: 21(1)

Published: March 13, 2025

This systematic literature review summarizes the evidence across 56 publications and pre-prints (January 2020–July 2023) with low-risk of bias based on JBI critical appraisal, that report adjusted estimates for relationship between COVID-19 vaccination Post-COVID-19 Condition (PCC) by timing relative to infection or PCC-onset. Comparisons vaccine effectiveness (aVE) against ≥1 PCC (vs. unvaccinated) study characteristics known impact burden VE other endpoints were possible 31 studies where preceded infection. Seventy-seven percent pre-infection aVE statistically significant (range: 7%–95%). Statistically slightly higher mRNA 14%–84%) than non-mRNA vaccines 16%–38%) ranges before during Omicron overlapped. Our findings suggest SARS-CoV-2 reduces risk regardless type, number doses received, definition, predominant variant, severity acute infections included.

Language: Английский

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Social determinants of recovery from ongoing symptoms following COVID-19 in two UK longitudinal studies: a prospective cohort study

BMJ Public Health, Journal Year: 2025, Volume and Issue: 3(1), P. e001166 - e001166

Published: Jan. 1, 2025

Introduction Social gradients in COVID-19 exposure and severity have been observed internationally. Whether combinations of pre-existing social factors, particularly those that confer cumulative advantage disadvantage, affect recovery from ongoing symptoms following long COVID is less well understood. Methods We analysed data on self-perceived self-reported illness two UK community-based cohorts, Symptom Study Biobank (CSSB) (N=2548) TwinsUK (N=1334). Causal effects sociodemographic variables reflecting status prior to the pandemic were estimated with multivariable Poisson regression models, weighted for inverse probability questionnaire participation infection adjusted potential confounders. Associations between strata comprising sex, education level local area deprivation using intersectional multilevel analysis individual heterogeneity discriminatory accuracy (MAIHDA) approach. Further analyses associations experiences during pandemic. Results Gradients along lines MAIHDA predicted lowest female highest levels (CSSB: 55.1% (95% CI 44.0% 65.1%); TwinsUK: 73.9% 61.1% 83.0%)) male 79.1% 71.8% 85.1%); 89.7% 82.5% 94.1%)). not explained by differences prepandemic health. Adverse employment, financial, healthcare access personal also negatively associated recovery. Conclusions Inequalities likelihood observed, several months after coronavirus more likely individuals greater disadvantage

Language: Английский

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The Association Between Self-Reported Long COVID Symptoms and COVID-19 Conspiracy Theories in Jordan, Kuwait, among Other Arab Countries

Published: Aug. 8, 2024

Long COVID comprises persistent symptoms which extend beyond four weeks post-SARS-CoV-2 infection. The potential association between long and the endorsement of COVID-19 conspiracy theories has not been explored, particularly in Arab countries where high these reported. This study aimed to explore endorsing prevalence self-reported among adults Jordan Kuwait addition other countries. employed a cross-sectional design using an electronic self-administered survey Arabic language. Recruitment utilized snowball sampling via social media was distributed July 2024. instrument included sections on demographic information, history infection, vaccination status. manifestations were assessed score reflecting frequency intensity ten recognized with subsequent categorization into three categories: low, middle, high. beliefs measured 5-point Likert scale across five items. final sample comprised 756 respondents, majority whom confirmed diagnosis at least once (n = 493, 65.2%). results indicated neutral average attitude towards (mean 15.18±4.64 out 30.00). Participants scores significantly more likely report (aOR 6.85, 95% CI: 2.90–16.13, p < 0.001) middle 2.82, 1.32–6.06, 0.008) compared those lower scores. Additional predictors higher reporting female sex household income. Frequent infections hospitalizations also associated symptom reporting. revealed significant correlation magnitude findings highlighted influence sociodemographic factors infection reporting, suggests that public health strategies should address mitigate challenges effectively.

Language: Английский

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The Association between Self-Reported Long COVID Symptoms and COVID-19 Conspiracy Theories in Jordan and Kuwait

COVID, Journal Year: 2024, Volume and Issue: 4(9), P. 1440 - 1462

Published: Sept. 12, 2024

Long COVID comprises persistent symptoms that extend beyond four weeks post-SARS-CoV-2 infection. The potential association between long and the endorsement of COVID-19 conspiracy theories has not been explored, particularly in Arab countries, where high these reported. This study aimed to explore endorsing prevalence self-reported among adults Jordan Kuwait addition other countries. employed a cross-sectional design using Computer-Assisted Web Interviewing (CAWI), conducted Arabic. Recruitment utilized convenience-based snowball sampling via social media survey was distributed July 2024. manifestations were assessed across ten recognized symptoms, belief measured five-point Likert scale five items. final sample comprised 755 respondents, majority whom history confirmed diagnosis at least once (n = 493, 65.2%). results indicated neutral average attitude towards (mean score 15.18 ± 4.64 out 30.00). Participants with scores more likely report (aOR 6.85, p < 0.001) or middle 2.82, 0.008) compared those lower scores. Additional predictors higher reporting included female sex, household income, frequent infections, hospitalizations. revealed significant correlation frequency magnitude symptom reporting. findings also highlighted influence sociodemographic factors infection on reporting, which suggests public health strategies should address mitigate challenges effectively.

Language: Английский

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Factors affecting the impact of COVID-19 vaccination on post COVID-19 conditions among adults: A Systematic Literature Review

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Oct. 4, 2024

Abstract Importance Existing systematic literature reviews (SLRs) on COVID-19 vaccine effectiveness (VE) against post-COVID-19 conditions (PCC) document high heterogeneity across studies, but have not compared VE design features known to impact PCC burden or other endpoints. Objective This SLR summarizes the evidence studies among predominately adults that report an adjusted measure of association for relationship between vaccination and PCC, by timing relative infection PCC-onset different study characteristics. Evidence review A comprehensive search strategy was developed within OVID platform EMBASE, MEDLINE® Evidence-Based Medicine reviews, supplemented with WHO COVID library Google Scholar® searches, collate published posted as pre-prints January 1 st , 2020 July 18 th 2023. JBI Critical Appraisal Checklists were used assess each study’s risk bias. Findings included 97 synthesized results from 56 low bias reported measures PCC. Overall, 77% pre-infection (aVE) estimates (vs. unvaccinated) statistically significant (range: 7%–95%), 80% reflecting a mix those vaccinated before after 62%–73%), one five onset (aVE=41%), 43% post-infection (two protective [range: 28%–40%] [aVE=-47%]), 46% specifying (23 29%–75%] [aVE=-132%]). Statistically aVE slightly higher mRNA 14%–84%) than non-mRNA vaccines 16%–38%) ranges during (4 studies; range: 10%–70%) Omicron predominance (10 7%–50%) overlapped. Pre-infection regardless type, number doses received, definition, predominant variant, severity acute infections included. Conclusions Relevance Collectively our findings suggest received prior SARS-CoV-2 reduces subsequent developing variant circulating. Key points Question Do vary onset, type disease severity? appeared reduce unvaccinated). Compared types, seemed offer greater protection, dose response observed vaccines. Meaning Despite reduced ≥1 proportion sample hospitalized, definition.

Language: Английский

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Perspective Chapter: Exploring Cognitive Impairment in Long COVID – Insights and Therapeutic Progress

IntechOpen eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 4, 2024

Coronavirus disease 2019 (COVID-19) was caused by a novel severe acute respiratory syndrome related coronavirus (SARS-CoV-2) that occurred in late and soon emerged as global pandemic. Even after recovering from the initial infection, approximately 45% of patients experience persistent symptoms, known post-COVID syndromes or long COVID, which can endure for weeks to months. Among prominent lingering symptoms are fatigue, cognitive impairment (commonly referred brain fog), musculoskeletal disorders. Brain fog manifests confusion, difficulty focusing, memory loss. Although exact cause deficits induced SARS-CoV-2 remains unclear, it is speculated chronic inflammation resulting residual virus remnants body’s reservoirs stress-released peptides may play significant role. This chapter aims delve into etiology recent advancements treating associated with COVID-19, shedding light on our understanding this complex phenomenon potential therapeutic strategies.

Language: Английский

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