Serotonergic psychedelics as potential therapeutics for post-COVID-19 syndrome (or Long COVID): A comprehensive review

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown, P. 111279 - 111279

Published: Feb. 1, 2025

Language: Английский

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Assessment of psychosocial aspects in adults in post-COVID-19 condition: the EURONET-SOMA recommendations on core outcome domains for clinical and research use

BMC Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: Feb. 11, 2025

Abstract Background Harmonizing core outcome domains allows for pooling data, comparing interventions, and streamlining research evaluation. At the same time clinicians require concise feasible measures routine practice. Considering heterogeneity of post-COVID-19 condition, a biopsychosocial approach requires sufficient coverage psychosocial dimension with assessments. Previous recommendations sets have serious limitations regarding aspects condition. This paper specifically focuses on outcomes adults providing both comprehensive set streamlined clinical tailored use. Methods In structured Consensus Development Approach, European Network to improve diagnostic, treatment, healthcare patients persistent somatic symptoms (EURONET-SOMA) developed assessments The experts identified variables instruments which should be considered in studies suffering from are setting relevant research. Results We three higher-order dimensions each encompassing several domains: first dimension, “outcomes”, encompasses (1) classification/ diagnostics (2) (including fatigue), (3) psychopathological status mental comorbidities, (4) physical (5) neurocognitive symptoms, (6) illness consequences. second domain “mechanisms” (7) cognitive components, (8) affective (9) behavioral (10) social (11) psychobiological bridge markers (e.g., neuroimmunological psychoneuroendocrinological variables). third domain, “risk factors”, includes factors such as (12) socioeconomic sociocultural factors, (13) pre-existing health issues, (14) personality neuroticism), (15) adverse childhood experiences, (16) ongoing disability or pension claim, (17) media For specific suggested purposes Conclusions recommended help increase consistency condition across investigations, synergies, facilitate decision-making when different interventional approaches. It better identify subgroups heterogeneous populations offering practical tools practice through set.

Language: Английский

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Long Covid oder psychisch krank?

MMW - Fortschritte der Medizin, Journal Year: 2025, Volume and Issue: 167(5), P. 60 - 65

Published: March 1, 2025

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Cardiac symptoms in patients 3–6 months after contracting COVID-19– data from the polish STOP-COVID registry

BMC Infectious Diseases, Journal Year: 2025, Volume and Issue: 25(1)

Published: April 9, 2025

Abstract Background Common complaints of long COVID patients are cardiac symptoms such as fatigue, weakness, and a feeling palpitations. The study aimed to investigate the clinical features with persistent cardiological occurring within 3 6 months after COVID-19. Differences in ambulatory blood pressure monitoring (ABPM), Holter ECG (electrocardiogram) Echocardiography between people without were evaluated. We also assessed whether anxiety depression may be implicated outcomes. Materials methods This was retrospective affiliated STOP-COVID registry who attended follow-up visit 3–6 undergoing present performed tests: ABPM, Echocardiography. 504 additionally had GAD-2 (Generalized Anxiety Disorder 2-item) PHQ-2 (Patient Health Questionnaire-2) tests performed. Results analysis included 1080 patients. At least 1 analyzed 586 (54.3%). most common symptom fatigue (38.9%). Comparing or palpitations showed that mean value ventricular extrasystole higher former group ( p = 0.011). symptoms, there differences values 0.022) < 0.001) scales, well percentage responses related risk depression. Conclusion Cardiological among health issues must face contracting People more excessive extrasystoles than these symptoms. Trial registration Our based on medical data COVID-19 treated out-patient basis Polish Long-Covid Cardiovascular (PoLoCOV-CVD) (ClinicalTrials.gov identifier– NCT05018052, date 29.05.2020). Consent conduct obtained from Bioethics Committee District Medical Chamber Lodz (no. KB-0115/2021).

Language: Английский

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Emotional distress during the first year of the COVID-19 pandemic-large sample serbian study

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 11, 2025

The COVID-19 pandemic has significantly impacted mental health, with healthcare professionals being particularly vulnerable. This study explores the emotional distress experienced in Serbia, focusing on factors that contribute to symptoms of depression, anxiety, and stress. A total 3328 participants from general populations were surveyed using Depression Anxiety Stress Scales-Short Form (DASS-21). analysis revealed certain groups, such as women, non-psychiatrist doctors, individuals a history disorders, those dissatisfied their financial, familial, living circumstances, more likely experience heightened levels Moreover, professionals, especially working challenging conditions, may be at increased risk for health issues. These findings underscore need targeted interventions ongoing support most affected, within sector, mitigate long-term impacts pandemic.

Language: Английский

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Positionspapier zum Post-COVID-Syndrom

Deleted Journal, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 3, 2025

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Development of an expectation management intervention for patients with Long COVID: A focus group study with affected patients

PLoS ONE, Journal Year: 2025, Volume and Issue: 20(2), P. e0317905 - e0317905

Published: Feb. 3, 2025

Background A significant number of individuals who have contracted SARS-CoV-2 report persistent somatic symptoms after the infection has resolved. Evidence-based treatment options for Long COVID are lacking to date. To ensure that an expectation management intervention, designed research project SOMA.COV, addresses relevant patient needs as well promote acceptance and adherence, a participatory approach was chosen. Objective The aim present study explore wishes patients with regarding preliminary version intervention thereby inform further development manual. Methods Twenty-two affected by participated in one four focus groups June July 2023. Participants were presented draft content four-session intervention. Feedback audio-recorded, transcribed, analyzed using thematic analysis. Results Thirteen themes relating main components manual developed. Large parts received overall positive feedback, including psychoeducation on biopsychosocial etiology condition, elements cognitive restructuring, imagination exercise. Patients’ response vicious circle fear behavior change exercise mixed. Modifications made patients’ feedback. Conclusion Patients provided feedback while also highlighting important adaptations necessary this group. results informed finalization within SOMA.COV project, which investigates effectiveness three-armed randomized controlled trial.

Language: Английский

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Effects of Biopsychosocial Factors on Quality of Life among Adolescents during the COVID-19 Outbreak: A Comparative Cross-sectional Study

Journal of Child and Family Studies, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 27, 2025

Language: Английский

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The implications of somatic symptom disorder on the impairment of daily life are greater in post-COVID syndrome than in asthma or COPD - results of a cross-sectional study in a rehabilitation clinic

Scientific Reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 5, 2025

Abstract The aim was to compare the relationship between somatic symptom disorder (SSD), anxiety, depression, clinical symptoms, and daily life impairment (DLI) in post-COVID syndrome (PCS), asthma chronic obstructive pulmonary disease (COPD). In a cross-sectional study, 371 patients (161 PCS, 121 asthma, 89 COPD) of rehabilitation clinic received questionnaires PHQ-15 (Patient Health Questionnaire-15) SSD-12 (Somatic Symptom Disorder-12) determine SSD, GAD-7 (Generalized Anxiety Disorder-7) anxiety disorder, PHQ-9 Questionnaire-9) depression. Lung function estimated using whole-body plethysmography. Predictors for DLI were assessed by regression models ROC analyses. Association SSD with stronger PCS (odds ratio 13.8; 95% confidence interval 1.7-109.9) than (8.5; 2.4–30.1), not significant COPD (1.9; 0.5–7.5). COPD, strongest predictors (15.0; 1.9-116.8) (8.9; 1.1–71.8), respectively. Diffusion capacity predictive (0.947; 0.916–0.979) (0.967; 0.943–0.993), but PCS. To conclude, appears have greater impact on or patients. This should be recognized appropriately during rehabilitation. Furthermore, increased psychological comorbidity also considered adequately treated if necessary.

Language: Английский

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Pathophysiological, Neuropsychological, and Psychosocial Influences on Neurological and Neuropsychiatric Symptoms of Post-Acute COVID-19 Syndrome: Impacts on Recovery and Symptom Persistence

Biomedicines, Journal Year: 2024, Volume and Issue: 12(12), P. 2831 - 2831

Published: Dec. 13, 2024

Although the impact of post-acute COVID-19 syndrome (PACS) on patients and public health is undeniably significant, its etiology remains largely unclear. Much research has been conducted pathophysiology, shedding light various aspects; however, due to multitude symptoms clinical conditions that directly or indirectly define PACS, it challenging establish definitive causations. In this exploration, through systematically reviewing latest pathophysiological findings related neurological syndrome, we aim examine how psychosocial neuropsychological may overlap with ones, they not only serve as risk factors but also contribute persistence some primary disorder. Findings from our synthesis suggest psychological factors, such anxiety, depression, loneliness, interact in a self-reinforcing feedback loop. This cycle seems be affecting both physical distress, potentially increasing severity PACS symptoms. By pointing out interaction, review study, attempt offer new perspective interconnected nature psychological, psychosocial, emphasizing importance integrated treatment approaches disrupt improve outcomes when possible.

Language: Английский

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