Lights and Shadows of Long COVID: Are Latent Infections the Real Hidden Enemy? DOI Open Access
Francesca Serapide, Marisa Talarico, Salvatore Rotundo

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(23), P. 7124 - 7124

Published: Nov. 25, 2024

Long COVID-19 (LC) is a poorly understood, multifactorial condition that persists for at least three months following SARS-CoV-2 infection. The underlying pathophysiological mechanisms responsible the wide range of associated symptoms-including fatigue, brain fog, and respiratory issues-remain unclear. However, emerging evidence suggests reactivation latent viral infections, such as Epstein-Barr virus, cytomegalovirus, varicella-zoster may significantly contribute to complexity LC. These viruses can be reactivated by SARS-CoV-2, contributing chronic inflammatory state prolongs symptomatology. This review confirms potential involvement infections in LC examines whether these play an independent role or act synergistically with other factors. In addition, recent studies have highlighted persistence immune dysregulation key elements Our findings suggest preventative strategies, including vaccination antiviral treatments during acute phase COVID-19, show reducing risk preventing reactivation. tailored diagnostic therapeutic strategies targeting are urgently needed. Identifying biomarkers reactivation, particularly high-risk populations, could considered another effective strategy mitigate severity. Further research crucial better understand interactions between improve prevention treatment

Language: Английский

Distinct pro-inflammatory/pro-angiogenetic signatures distinguish children with Long COVID from controls DOI
Danilo Buonsenso,

Nicola Cotugno,

Donato Amodio

et al.

Pediatric Research, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 23, 2025

Language: Английский

Citations

1
Post‑COVID syndrome in children compared with adults (Review) DOI Open Access
Helena C. Maltezou

World Academy of Sciences Journal, Journal Year: 2025, Volume and Issue: 7(2)

Published: Jan. 15, 2025

Post‑COVID‑19 syndrome (or long‑COVID) was recognized as a clinical entity early in the spring of 2020, when it documented that non‑negligible number patients with COVID‑19 continued to exhibit symptoms several weeks following severe acute respiratory coronavirus 2 (SARS‑CoV‑2) infection. Although beginning pandemic considered almost all SARS‑CoV‑2 infections children and adolescents were either asymptomatic or mildly symptomatic, duly noted may also experience prolonged therefore manifest post‑COVID syndrome. It subsequently involve multiple organs systems persist, majority cases, for months; however, some cases persisted even 1 year follow‑up. There is evidence indicate are at an increased risk developing anxiety, depression loss appetite, while overall impact on developmental psychological domain well‑being remains largely unknown. The present review discusses current state knowledge compares adults. Issues pathogenesis, prognosis, role vaccination implications future research discussed.

Language: Английский

Citations

0
Management of SARS-CoV-2 Infection-Clinical Practice Guidelines of the Polish Association of Epidemiologists and Infectiologists, for 2025 DOI Open Access
Robert Flisiak, Jerzy Jaroszewicz, Dorota Kozielewicz

et al.

Journal of Clinical Medicine, Journal Year: 2025, Volume and Issue: 14(7), P. 2305 - 2305

Published: March 27, 2025

The first Polish recommendations for the management of COVID-19 were published by Society Epidemiologists and Infectiologists (PTEiLChZ) on 31 March 2020, last three years ago. emergence new SARS-CoV-2 variants, a different course disease, as well knowledge about therapies vaccines, requires updating diagnostic, therapeutic, prophylactic guidelines. Despite reduction in threat associated with COVID-19, there is risk another epidemic caused coronaviruses, which was an additional reason developing version In preparing these recommendations, Delphi method used, reaching consensus after survey cycles. Compared to 2022 version, names individual stages disease have been changed, adapting them realities clinical practice, attention paid differences observed immunosuppressed patients children. Some previously recommended drugs discontinued, including monoclonal antibodies. addition, general principles vaccination presented, issues related post-COVID syndrome.

Language: Английский

Citations

0
Real-world effectiveness and causal mediation study of BNT162b2 on long COVID risks in children and adolescents DOI Creative Commons
Qiong Wu, Bingyu Zhang, Jiayi Tong

et al.

EClinicalMedicine, Journal Year: 2024, Volume and Issue: 79, P. 102962 - 102962

Published: Dec. 6, 2024

Language: Английский

Citations

4
Age differences in prevalence and symptoms of post-COVID-19 condition among children: a prospective cohort study DOI
Yixin Wu, Xiangrong Sun,

Jingyun Yang

et al.

European Journal of Pediatrics, Journal Year: 2025, Volume and Issue: 184(3)

Published: March 5, 2025

Language: Английский

Citations

0
Development and Validation of POCOKIDS‐Q—A Questionnaire to Assess Post COVID‐19 Symptoms in Children DOI Creative Commons
Charlotte Angelhoff,

M. Jedenfalk,

Eva Fernlund

et al.

Acta Paediatrica, Journal Year: 2025, Volume and Issue: unknown

Published: April 13, 2025

ABSTRACT Aim To identify the symptom burden in children and adolescents with post COVID‐19, a validated reliable instrument is needed, particularly to assess symptoms their impact on child. The aim of this study was describe development, validation, reliability Post COVID‐19 Kids Questionnaire (POCOKIDS‐Q), which designed adolescents. Methods POCOKIDS‐Q developed based literature, clinical experience, questionnaires for adults COVID‐19. linguistic validation involved 9‐ 17‐year‐old children. Children onset were asked complete final version through web link. Exploratory confirmatory factor analyses performed structure that explains covariances between variables. Results link opened 324 times fully completed by 213 (66%) young (median age 14 years) symptoms. Confirmatory revealed four significant correlated factors: brain fatigue, cognitive impact, physical emotional impact. explanatory power model high. Conclusion applicable assessing adults.

Language: Английский

Citations

0
Lights and Shadows of Long COVID: Are Latent Infections the Real Hidden Enemy? DOI Open Access
Francesca Serapide, Marisa Talarico, Salvatore Rotundo

et al.

Journal of Clinical Medicine, Journal Year: 2024, Volume and Issue: 13(23), P. 7124 - 7124

Published: Nov. 25, 2024

Long COVID-19 (LC) is a poorly understood, multifactorial condition that persists for at least three months following SARS-CoV-2 infection. The underlying pathophysiological mechanisms responsible the wide range of associated symptoms-including fatigue, brain fog, and respiratory issues-remain unclear. However, emerging evidence suggests reactivation latent viral infections, such as Epstein-Barr virus, cytomegalovirus, varicella-zoster may significantly contribute to complexity LC. These viruses can be reactivated by SARS-CoV-2, contributing chronic inflammatory state prolongs symptomatology. This review confirms potential involvement infections in LC examines whether these play an independent role or act synergistically with other factors. In addition, recent studies have highlighted persistence immune dysregulation key elements Our findings suggest preventative strategies, including vaccination antiviral treatments during acute phase COVID-19, show reducing risk preventing reactivation. tailored diagnostic therapeutic strategies targeting are urgently needed. Identifying biomarkers reactivation, particularly high-risk populations, could considered another effective strategy mitigate severity. Further research crucial better understand interactions between improve prevention treatment

Language: Английский

Citations

1