Association between the dietary index for gut microbiota and female infertility: a cross-sectional study of NHANES 2013–2018 DOI Creative Commons

Xiaoyan Zhang,

Liangzhi Wu, Haiyan Li

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: April 28, 2025

Background Infertility poses a substantial societal and economic burden; however, current preventive strategies are limited. Recently, the relationship between gut microbiota infertility has garnered increasing attention. The dietary index for (DI-GM) is new that reflects diversity of microbiota. However, its association with female remains unclear. Methods This cross-sectional study included 3,053 women aged 18–45 years from National Health Nutrition Examination Survey (NHANES) database 2013 2018. was defined based on responses to questionnaire reproductive health. DI-GM score calculated by averaging intake two 24-h recall interviews. Weighted multivariable logistic regression, restricted cubic splines (RCS), subgroup analyses were used investigate infertility. Results Based self-reported data, 370 participants (12.12%) classified as infertile. A higher proportion lower scores experienced Multivariable regression analysis indicated negative risk infertility, regardless whether independent variable analyzed continuous or in quartiles fully adjusted model (Model 3, variable: OR = 0.89, 95% confidence interval (CI): 0.80–0.98, p 0.025; Q4 vs. Q1: 0.63, CI 0.42–0.94, 0.032, trend 0.013). RCS curves demonstrated non-linear risk. Subsequent corroborated robustness these findings. Conclusion These findings suggest females, associated

Language: Английский

Metabolic disorders in polycystic ovary syndrome: from gut microbiota biodiversity to clinical intervention DOI Creative Commons
Jiyuan Li, Jie Qiao, Yihan Li

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: April 28, 2025

Polycystic ovary syndrome (PCOS) is a prevalent gynecologic endocrine disorder characterized by menstrual irregularities, elevated androgen levels, and ovulatory dysfunction. Its etiology multifactorial. Emerging evidence indicates that PCOS patients exhibit diminished gut microbiota (GM) diversity altered microbial ratios, contributing to the metabolic derangements observed in these individuals. This review elucidates role of GM pathogenesis disorders PCOS, encompassing insulin resistance (IR), hormonal imbalances, bile acid disorders, Interleukin-22-mediated immune dysregulation, brain-gut axis disturbances. Additionally, it synthesizes current therapeutic strategies targeting GM, aiming furnish theoretical framework for prospective clinical interventions.

Language: Английский

Citations

0
Association between the dietary index for gut microbiota and female infertility: a cross-sectional study of NHANES 2013–2018 DOI Creative Commons

Xiaoyan Zhang,

Liangzhi Wu, Haiyan Li

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: April 28, 2025

Background Infertility poses a substantial societal and economic burden; however, current preventive strategies are limited. Recently, the relationship between gut microbiota infertility has garnered increasing attention. The dietary index for (DI-GM) is new that reflects diversity of microbiota. However, its association with female remains unclear. Methods This cross-sectional study included 3,053 women aged 18–45 years from National Health Nutrition Examination Survey (NHANES) database 2013 2018. was defined based on responses to questionnaire reproductive health. DI-GM score calculated by averaging intake two 24-h recall interviews. Weighted multivariable logistic regression, restricted cubic splines (RCS), subgroup analyses were used investigate infertility. Results Based self-reported data, 370 participants (12.12%) classified as infertile. A higher proportion lower scores experienced Multivariable regression analysis indicated negative risk infertility, regardless whether independent variable analyzed continuous or in quartiles fully adjusted model (Model 3, variable: OR = 0.89, 95% confidence interval (CI): 0.80–0.98, p 0.025; Q4 vs. Q1: 0.63, CI 0.42–0.94, 0.032, trend 0.013). RCS curves demonstrated non-linear risk. Subsequent corroborated robustness these findings. Conclusion These findings suggest females, associated

Language: Английский

Citations

0