Predictability of varicocele repair success: preliminary results of a machine learning-based approach DOI Creative Commons
Andrea Crafa, Marco Russo, Rossella Cannarella

et al.

Asian Journal of Andrology, Journal Year: 2024, Volume and Issue: 27(1), P. 52 - 58

Published: Aug. 9, 2024

Abstract Varicocele is a prevalent condition in the infertile male population. However, to date, which patients may benefit most from varicocele repair still matter of debate. The purpose this study was evaluate whether certain preintervention sperm parameters are predictive successful repair, defined as an improvement total motile count (TMSC). We performed retrospective on 111 with who had undergone collected Department Endocrinology, Metabolic Diseases and Nutrition, University Catania (Catania, Italy), Unit Urology at Selcuk School Medicine (Konya, Türkiye). analysis conducted through use Brain Project, innovative tool that allows complete totally unbiased search mathematical expressions relate object various available. considered when TMSC increased by least 50% value. For below 5 × 10 6 , clinically relevant increase exceeded absolute value >5 . From alone, we found model predicts appear little sensitivity 50.0% specificity 81.8%. grade serum follicle-stimulating hormone (FSH) levels did not play role, but it should be noted all enrolled were selected intermediate- or high-grade normal FSH levels. In conclusion, success terms varicoceles

Language: Английский

Detection and characterization of microplastics in the human testis and semen DOI
Qiancheng Zhao, Long Zhu,

Jiaming Weng

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 877, P. 162713 - 162713

Published: March 21, 2023

Language: Английский

Citations

205
Raman Microspectroscopy evidence of microplastics in human semen DOI Creative Commons
Luigi Montano, Elisabetta Giorgini, Valentina Notarstefano

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 901, P. 165922 - 165922

Published: July 31, 2023

The presence of microplastics (MPs) in human fluids and organs is a great concern, since, as highlighted by recent studies on animal models, they could cause alterations several physiological functions, including reproduction. In this study, semen samples collected from men living polluted area the Campania Region (Southern Italy), were analyzed to assess MPs. N. 16 pigmented microplastic fragments (ranging 2 6 μm size) with spheric or irregular shapes found six out ten samples. All detected MPs characterized terms morphology (size, colour, shape) chemical composition Raman Microspectroscopy. Chemical showed polypropylene (PP), polyethylene (PE), terephthalate (PET), polystyrene (PS), polyvinylchloride (PVC), polycarbonate (PC), polyoxymethylene (POM) acrylic, suggesting ingestion and/or inhalation route exposure environmental work, we propose for first time mechanism which pass into most likely through epididymis seminal vesicles, are susceptible inflammation.

Language: Английский

Citations

105
Update of the risk assessment of inorganic arsenic in food DOI Creative Commons

Dieter Schrenk,

Margherita Bignami,

Laurent Bodin

et al.

EFSA Journal, Journal Year: 2024, Volume and Issue: 22(1)

Published: Jan. 1, 2024

The European Commission asked EFSA to update its 2009 risk assessment on arsenic in food carrying out a hazard of inorganic (iAs) and using the revised exposure issued by 2021. Epidemiological studies show that chronic intake iAs via diet and/or drinking water is associated with increased several adverse outcomes including cancers skin, bladder lung. CONTAM Panel used benchmark dose lower confidence limit based response (BMR) 5% (relative increase background incidence after adjustment for confounders, BMDL05) 0.06 μg iAs/kg bw per day obtained from study skin cancer as Reference Point (RP). Inorganic As genotoxic carcinogen additional epigenetic effects applied margin (MOE) approach characterisation. In adults, MOEs are low (range between 2 0.4 mean consumers 0.9 0.2 at 95th percentile exposure, respectively) such raise health concern despite uncertainties.

Language: Английский

Citations

61
Spatiotemporal trends in human semen quality DOI Open Access
Jacques Auger, Florence Eustache, Cécile Chevrier

et al.

Nature Reviews Urology, Journal Year: 2022, Volume and Issue: 19(10), P. 597 - 626

Published: Aug. 17, 2022

Language: Английский

Citations

56
Temporal decline of sperm concentration: role of endocrine disruptors DOI
Rossella Cannarella, Murat Gül, Amarnath Rambhatla

et al.

Endocrine, Journal Year: 2022, Volume and Issue: 79(1), P. 1 - 16

Published: Oct. 4, 2022

Language: Английский

Citations

54
Molybdenum and cadmium cause blood–testis barrier dysfunction through ROS-mediated NLRP3 inflammasome activation in sheep DOI
Lu Jiang, Fan Yang, Huan Liao

et al.

The Science of The Total Environment, Journal Year: 2023, Volume and Issue: 906, P. 167267 - 167267

Published: Sept. 22, 2023

Language: Английский

Citations

38
Multiple Targets of Toxicity in Environmental Exposure to Low-Dose Cadmium DOI Creative Commons

Soisungwan Satarug,

Glenda C. Gobé, David A. Vesey

et al.

Toxics, Journal Year: 2022, Volume and Issue: 10(8), P. 472 - 472

Published: Aug. 13, 2022

Dietary assessment reports and population surveillance programs show that chronic exposure to low levels of environmental cadmium (Cd) is inevitable for most people, adversely impacts the health children adults. Based on a risk model considers an increase in excretion β2-microglobulin (β2M) above 300 μg/g creatinine be “critical” toxicity endpoint, tolerable intake level Cd was set at 0.83 µg/kg body weight/day, urinary rate 5.24 µg/g considered threshold level. The aim this review draw attention many other endpoints are both clinically relevant more appropriate derive limits than β2M endpoint. In present review, we focus reduction glomerular filtration diminished fecundity because low-dose Cd, reflected by its as 0.5 creatinine, have been associated with dose-dependent increases these pathological symptoms. Some protective effects nutritionally essential elements selenium zinc highlighted. Cd-induced mitochondrial dysfunction discussed potential mechanism underlying gonadal toxicities infertility.

Language: Английский

Citations

30
Cadmium-induced Sertoli Cell Injury Through p38-MAPK and Related Signaling Proteins—A Study by RNA Sequencing DOI
Lingling Wang, Xinyao Li,

Tiao Bu

et al.

Endocrinology, Journal Year: 2023, Volume and Issue: 164(6)

Published: March 16, 2023

Abstract Environmental toxicants, such as cadmium, found in foods, water, and consumer products are known to induce male reproductive dysfunction. However, the underlying molecular mechanism(s) by which cadmium-induced Sertoli cell injury manifested a disruption of blood-testis barrier (BTB) remains unknown. Interestingly, one primary targets cadmium toxicity testis is cytoskeletons cells, which, turn, impedes junctions seminiferous epithelium. In order expand these earlier observations provide roadmap for future studies, we embarked study using RNA sequencing identify pertinent genes involved injury. Using bioinformatics analyses, multiple gene sets that regulated actin microtubule (MT) were identified along with components mitogen-activated protein kinase (MAPK) signaling several pathways. More important, have also discovered while expression p38-MAPK (also JNK or c-Jun) was considerably up- downregulated during injury, activated (phosphorylated) form upregulated. Importantly, doramapimod BIRB 796), specific p38-MARK inhibitor, shown selectively block p-p38 MAPK activation via phosphorylation indeed capable blocking including cell-permeability function, disruptive distribution BTB-associated proteins, organization MT cytoskeletons. These data helpful source information investigators probe role proteins and/or their cascades, besides MAPKs, likely utilized

Language: Английский

Citations

14
The interaction between selenium and cadmium in the soil-rice-human continuum in an area with high geological background of selenium and cadmium DOI Creative Commons
Ruyi Yang, Yuhuan He,

Linfeng Luo

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2021, Volume and Issue: 222, P. 112516 - 112516

Published: July 15, 2021

Natural selenium (Se)-rich areas in China are generally characterized by high geological background of cadmium (Cd). However, the interaction between Se and Cd soil-rice-human continuum such remains elusive. The concentrations, bioaccessibilities, biomarkers a typical Se-Cd rich area were determined through chemical analysis, vitro digestion model cross-sectional study, respectively. results showed that molar ratio available Se/Cd soil was averaged at 0.55 did not reduce accumulation transportation rice. bioaccessibility increased from gastric phase to intestinal phase, but opposite case for bioaccessibility. Moreover, bioaccessible concentration positively correlated corresponding total rice negatively associated with logarithm Se/Cd. risk Cd-induced nephrotoxicity exposure group higher than reference group, which could be ascribed mitigative effect Se. Males elders injury owing urinary (U-Cd) β2-microglobulin (U-β2-MG), lower (U-Se). Our suggested health should assessed perspective taken into account.

Language: Английский

Citations

28
Obesity and Male Reproduction: Do Sirtuins Play a Role? DOI Open Access
Federica Barbagallo, Sandro La Vignera, Rossella Cannarella

et al.

International Journal of Molecular Sciences, Journal Year: 2022, Volume and Issue: 23(2), P. 973 - 973

Published: Jan. 16, 2022

Obesity is a major current public health problem of global significance. A progressive sperm quality decline, and decline in male fertility, have been reported recent decades. Several studies strict relationship between obesity reproductive dysfunction. Among the many mechanisms by which impairs gonadal function, sirtuins (SIRTs) an emerging role. SIRTs are highly conserved nicotinamide adenine dinucleotide (NAD+)-dependent deacetylases that play role gene regulation, metabolism, aging, cancer. regulate energy balance, lipid glucose adipogenesis, but evidence also indicates for reproduction. However, majority conducted animal models very few with humans. This review shows important among molecular interferes fertility. highlights need to deepen this relationship. It will be particular interest evaluate whether synthetic and/or natural compounds capable modifying activity may useful treatment its effects on function. Although explored SIRT activators obesity-induced infertility, some molecules, such as resveratrol, appear effective modulating activity, well counteracting negative The search strategies improve function overweight/obese patients challenge understanding their open new interesting scenarios coming years.

Language: Английский

Citations

20