Research Square (Research Square),
Journal Year:
2022,
Volume and Issue:
unknown
Published: May 9, 2022
Abstract
Background:
Extensive
studies
revealed
the
association
between
heavy
metals
and
CKD.
Compared
with
single
meta,
mixtures
reflect
exposure
scenarios
in
real
life
deserves
attention.
While
mechanism
of
action
metal
mixture
on
renal
function
is
still
undefined.
Methods:
A
cross-sectional
study
involving
2775
participants
was
conducted.
Urinary
concentrations
were
measured
by
inductively
coupled
plasma
mass
spectrometry,
estimated
glomerular
filtration
rate
(eGFR)
for
calculated.
The
eGFR
linear
regression.
Interaction
used
to
evaluate
using
a
Bayesian
nuclear
machine
regression
model
(BKMR).
Results:
In
regression,
urinary
As
(β
=
2.723,
P<0.05)
Pb
3.081,
positively
correlated
total
population.
BKMR
model,
five
had
positive
joint
effect
levels,
(PIP
0.996)
contributed
most
levels.
significantly
associated
levels
women.
displayed
significant
when
all
other
fixed
at
25th,
50th,
75th
percentiles.
Conclusions:
To
best
our
knowledge
All
mixed
eGFR,
while
demonstrated
more
important
effects
than
four
mixture,
especially
British Journal Of Nutrition,
Journal Year:
2023,
Volume and Issue:
131(6), P. 1031 - 1040
Published: Nov. 6, 2023
Abstract
Dietary
antioxidant
indices
(DAI)
may
be
potentially
associated
with
relative
telomere
length
(RTL)
of
leucocytes.
This
study
aimed
to
investigate
the
relationship
between
DAI
and
RTL.
A
cross-sectional
involving
1656
participants
was
conducted.
generalised
linear
regression
model
a
restricted
cubic
spline
were
used
assess
correlation
its
components
Generalised
analysis
revealed
that
(
β
=
0·005,
P
0·002)
intake
constituents
vitamin
C
0·043,
0·027),
E
0·088,
<
0·001),
Se
0·075,
0·003),
Zn
0·023)
significantly
positively
correlated
Sex-stratified
showed
0·006,
0·005)
0·083,
0·012),
0·093,
0·006),
0·092,
0·034)
RTL
among
females.
Meanwhile,
males,
only
0·089,
0·013)
Restricted
positive
associations
constituents’
(vitamin
E,
Zn)
in
total
population.
Our
found
significant
RTL,
sex
differences.
Research Square (Research Square),
Journal Year:
2023,
Volume and Issue:
unknown
Published: Dec. 12, 2023
Abstract
Studies
indicate
a
link
between
the
presence
of
various
heavy
metals
and
development
insulin
resistance.
We
sought
to
evaluate
association
levels
certain
urinary
metals,
including
barium,
cadmium,
lead,
molybdenum,
strontium,
uranium,
others,
with
incidence
diabetes.
The
prevalence
diabetes
was
assessed
by
retrieving
analyzing
health
questionnaire
for
patients
data
from
NHANES
2013
2018.
observed
that
barium
(β
=
0.04
95%
CI:
0.01,
0.1),
strontium
0.1)
uranium
(β=-0.02
-0.04,
0.004)
were
positively
correlated
risk
developing
In
addition,
consistent
trends
maintained
in
quantile
regression
models.
After
adjusting
covariates
(sex,
age,
education
level,
race,
BMI,
income,
metals)
associations
blood
0.03,
-0.06,
0.11),
0.00)
0.10,
-0.22,
0.43)
showed
linear
relationships
role
mixed
metal
exposure
evaluated
using
weighted
quantiles
sum
(WQS)
model.
According
WQS
analysis,
substantially
associated
chance
acquiring
1.02,
1.01,
1.03).
Therefore,
our
research
there
positive
correlations
diabetes,
also
had
substantial
impact
on
exposure,
which
causes
serious
harm
human
body.
Research Square (Research Square),
Journal Year:
2022,
Volume and Issue:
unknown
Published: May 9, 2022
Abstract
Background:
Extensive
studies
revealed
the
association
between
heavy
metals
and
CKD.
Compared
with
single
meta,
mixtures
reflect
exposure
scenarios
in
real
life
deserves
attention.
While
mechanism
of
action
metal
mixture
on
renal
function
is
still
undefined.
Methods:
A
cross-sectional
study
involving
2775
participants
was
conducted.
Urinary
concentrations
were
measured
by
inductively
coupled
plasma
mass
spectrometry,
estimated
glomerular
filtration
rate
(eGFR)
for
calculated.
The
eGFR
linear
regression.
Interaction
used
to
evaluate
using
a
Bayesian
nuclear
machine
regression
model
(BKMR).
Results:
In
regression,
urinary
As
(β
=
2.723,
P<0.05)
Pb
3.081,
positively
correlated
total
population.
BKMR
model,
five
had
positive
joint
effect
levels,
(PIP
0.996)
contributed
most
levels.
significantly
associated
levels
women.
displayed
significant
when
all
other
fixed
at
25th,
50th,
75th
percentiles.
Conclusions:
To
best
our
knowledge
All
mixed
eGFR,
while
demonstrated
more
important
effects
than
four
mixture,
especially
