Recent evidence for toxic effects of NH3 exposure on lung injury: Protective effects of L-selenomethionine

Ecotoxicology and Environmental Safety, Journal Year: 2022, Volume and Issue: 242, P. 113937 - 113937

Published: Aug. 3, 2022

Ammonia (NH3) is a common air pollutant, which poses serious threat to farm animals. L-selenomethionine organic selenium (Se), can inhibit intracellular ROS generation, block ROS-dependent autophagy, promote mitochondrial energy metabolism, and enhance the body's immunity. Lung, as an important organ of respiratory system, highly susceptible toxic effects NH3. However, there were few studies on mechanism NH3 lung tissues. The aim this study was investigate effect lungs in pigs alleviating L-selenomethionine. Twenty-four Large White*Duroc*Min randomly assigned 4 groups: control group, Se +Se group. results showed that exposure caused damage inflammation tissues significantly increased blood concentration. induced changes oxidative stress indexes (GSH, GSH-Px, SOD, MDA, Keap1, Nrf2, HO-1) expressions metabolism related genes (HK1, HK2, PFK, PK, LDHA, HIF-1α). Ultrastructure autophagosome significantly, expression levels autophagy (Beclin1, ATG5, ATG7, ATG10, p62) changed. addition alleviated above changes, but still significant difference compared with group (P < 0.05). This finding provide new evidence for mitigation toxicity.

Language: Английский

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1,8-Cineole ameliorates endothelial injury and hypertension induced by L-NAME through regulation of autophagy via PI3K/mTOR signaling pathway

European Journal of Pharmacology, Journal Year: 2023, Volume and Issue: 954, P. 175863 - 175863

Published: June 26, 2023

Language: Английский

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Selenomethionine promotes ANXA2 phosphorylation for proliferation and protein synthesis of myoblasts and skeletal muscle growth

The Journal of Nutritional Biochemistry, Journal Year: 2023, Volume and Issue: 115, P. 109277 - 109277

Published: Feb. 2, 2023

Language: Английский

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The SLC38A9–mTOR axis is involved in autophagy in the juvenile yellow catfish (Pelteobagrus fulvidraco) under ammonia stress

Environmental Pollution, Journal Year: 2023, Volume and Issue: 343, P. 123211 - 123211

Published: Dec. 22, 2023

Language: Английский

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Low selenium and T-2 toxin may be involved in the pathogenesis of Kashin-Beck disease by affecting AMPK/mTOR/ULK1 pathway mediated autophagy

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 279, P. 116503 - 116503

Published: May 28, 2024

Kashin-Beck disease (KBD) is an endemic, environmentally associated cartilage disease. Previous studies have shown that the environmental suspected pathogenic factors of KBD, T-2 toxin and low selenium, are involved in regulation inflammation, oxidative stress autophagy some tissues organs. In diseases, level cellular determines fate chondrocytes. However, whether KBD lesions, role selenium toxins injury still unclear. This work took classical AMPK/mTOR/ULK1 regulatory pathway as entry point to clarify relationship between chondrocyte autophagy. Transmission electron microscopy was used observe chondrocytes patients. qRT-PCR western blot were analyze expression markers. The rat model established by toxin, detected after 4- 12-week interventions. Chondrocyte found down-regulated. model, showed up-regulated trend when treated for a short time or concentration, increased. long at high concentrations, down-regulated trend, reduced even defective. conclusion, process lesion, may increase early stage, decrease late stage with progression lesion. Low affect pathway.

Language: Английский

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The enhancing effects of selenomethionine on harmine in attenuating pathological cardiac hypertrophy via glycolysis metabolism

Journal of Cellular and Molecular Medicine, Journal Year: 2024, Volume and Issue: 28(19)

Published: Oct. 1, 2024

Pathological cardiac hypertrophy, a common feature in various cardiovascular diseases, can be more effectively managed through combination therapies using natural compounds. Harmine, β-carboline alkaloid found plants, possesses numerous pharmacological functions, including alleviating hypertrophy. Similarly, Selenomethionine (SE), primary organic selenium source, has been shown to mitigate autophagy and alleviate injury. To explores the therapeutic potential of combining Harmine with SE treat The synergistic effects harmine against hypertrophy were assessed vitro angiotensin II (AngII)-induced vivo Myh6

Language: Английский

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Selenium Mitigates Ammonia-Induced Neurotoxicity by Suppressing Apoptosis, Immune Imbalance, and Gut Microbiota-Driven Metabolic Disturbance in Fattening Pigs

Biological Trace Element Research, Journal Year: 2022, Volume and Issue: 201(7), P. 3341 - 3355

Published: Oct. 13, 2022

Language: Английский

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Selenium Alleviates Ammonia-Induced Splenic Cell Apoptosis and Inflammation by Regulating the Interleukin Family/Death Receptor Axis and Nrf2 Signaling Pathway

Biological Trace Element Research, Journal Year: 2022, Volume and Issue: 201(4), P. 1748 - 1760

Published: May 18, 2022

Language: Английский

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Selenomethionine Inhibits NF-κB-mediated Inflammatory Responses of Bovine Mammary Epithelial Cells Caused by Klebsiella pneumoniae by Increasing Autophagic Flux

Biological Trace Element Research, Journal Year: 2023, Volume and Issue: 202(4), P. 1568 - 1581

Published: July 5, 2023

Language: Английский

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Organic Selenium Alleviates Ammonia-Mediated Abnormal Autophagy by Regulating Inflammatory Pathways and the Keap1/Nrf2 Axis in the Hypothalamus of Finishing Pigs

Biological Trace Element Research, Journal Year: 2022, Volume and Issue: 201(8), P. 3812 - 3824

Published: Oct. 26, 2022

Language: Английский

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