SSRN Electronic Journal,
Journal Year:
2022,
Volume and Issue:
unknown
Published: Jan. 1, 2022
Deltamethrin
(Del)
has
been
widely
used
for
effectively
controlling
ectoparasites
of
crucian
carp
and
was
also
strictly
prohibited
in
a
hypoxic
environment.
The
previous
study
indicated
that
Del
exposure
cause
gills
injury
Carassius
auratus
,
which
were
associated
with
oxidative
stress
endoplasmic
reticulum
(ER
stress),
but
the
precise
mechanism
not
well
understood.
Here,
exposed
to
(0.61,
1.22,
2.44,
4.88
μg/L)
24
h,
then
subjected
acute
hypoxia
challenge
(1.0
mg/L)
h.
results
revealed
notably
increased
MDA
content
remarkably
decreased
CAT
activities.
Moreover,
T-AOC
SOD
activities
first
μg/L
group.
Likewise,
mRNA
levels
Nrf2
signaling
its
target
genes
(
ho-1
mt
sod
cat
gpx1
)
significantly
downregulated
high
concentration
groups,
while
keap1
showed
opposite
change
trend.
Meanwhile,
evoked
PERK-ATF4-CHOP
IRE1
pathway
triggered
ER
dose‐dependent
manner
carp.
Importantly,
we
found
survival
rate
after
via
reducing
oxygen
uptake,
modifying
energy
metabolism,
promoting
lactate
accumulation.
Also,
could
aggravate
gill
damage
under
stress,
confirmed
by
histology
assay.
Collectively,
inferred
deltamethrin
induces
impairs
resistance
Ecotoxicology and Environmental Safety,
Journal Year:
2022,
Volume and Issue:
241, P. 113732 - 113732
Published: June 6, 2022
The
indiscriminate
use
of
deltamethrin
in
agriculture
and
aquaculture
can
lead
to
residues
increased
many
regions,
which
poses
negative
impacts
on
intestinal
health
aquatic
organisms.
Although
the
potential
toxicity
have
recently
attracted
attention,
comprehensive
studies
injuries
after
chronic
exposure
remain
poorly
understood.
Herein,
a
28-day
test,
crucian
carp
expose
different
concentrations
(0,
0.3,
0.6
μg/L)
were
used
as
research
object.
We
found
that
morphology
changes
goblet
cells
tissue,
extent
tissue
injury
along
with
increasing
dose
deltamethrin.
Additionally,
genes
expression
antioxidant
activity
(Cu/Zn
superoxide
dismutase
(Cu-Zn
SOD),
glutathione
peroxidase
1
(GPX1),
catalase
(CAT)),
inflammatory
response
(tumor
necrosis
factor
alpha
(TNFα),
interferon
gamma
(IFNγ),
interleukin
beta
(IL-1β)),
tight
junctions
(Claudin
12
(CLDN12),
junction
protein
(ZO-1))
dramatically
increased.
Meanwhile,
apoptosis
autophagy
process
triggered
through
caspase-9
cascade
related
5
(ATG5)-
(ATG12)
conjugate.
Besides,
amount
Proteobacteria
Verrucomicrobiota,
while
decreased
Fusobacteriota
abundance,
resulting
microbiota
function
disorders.
In
summary,
our
results
highlight
cause
serious
physiological
flora
disturbances.
Ecotoxicology and Environmental Safety,
Journal Year:
2023,
Volume and Issue:
258, P. 114972 - 114972
Published: May 2, 2023
Cadmium
(Cd)
is
one
of
the
dominant
metal
pollutants
present
in
aquatic
environment
that
affects
ion
homeostasis,
oxidative
stress
(OS)
and
immune
responses
organisms.
Given
physicochemical
similarities
between
Cd2+
calcium
(Ca2+)
ions,
their
antagonism
may
facilitate
mitigation
Cd-induced
toxicity.
To
better
understand
role
Ca
protecting
against
toxicity
teleosts,
juvenile
grass
carp
were
exposed
to
Cd
(measured
concentration
3
μg/L)
a
gradient
concentrations
1.5
mg/L,
2.5
3.0
3.5
mg/L
control
(CTL)
group,
low
(LCA)
medium
(MCA)
high
(HCA)
respectively)
for
30
days.
Inductively
coupled
plasma
mass
spectrometry
(ICP-MS)
data
analyses
showed
simultaneous
exposure
impaired
accumulation
all
tested
tissues.
Besides,
addition
maintained
(Na+,
K+,
Cl-)
alleviated
(OS),
regulated
activities
transcriptional
levels
ATPase.
Furthermore,
heatmap
analysis
demonstrated
several
indicator
genes
OS
signaling
pathway
found
be
significantly
modulated
by
addition.
This
work
delineates
protective
effect
carp,
providing
new
insight
into
possible
solutions
pollution
issues
aquaculture
industry.
Frontiers in Toxicology,
Journal Year:
2025,
Volume and Issue:
7
Published: April 16, 2025
Deltamethrin
is
a
pyrethroid
insecticide
commonly
used
to
kill
animal
parasites
in
aquaculture.
However,
increasing
evidence
suggests
that
deltamethrin
affects
the
health
of
aquatic
animals
by
causing
tissue
damage
and
even
death.
In
this
study,
caused
gill
liver
tissues,
as
well
its
effects
on
oxidative
stress
immune
metabolism,
were
studied
Paralichthys
olivaceus.
We
observed
positive
correlation
between
residual
levels
(Del)
exposure
concentrations,
with
highest
residue
detected
0.28
μg/L
concentration
group
(0.0684
mg/kg
at
7
days).
Then,
we
different
degrees
tissues
olivaceus,
including
swelling,
apical
fusion,
shedding
secondary
lamellae,
cell
necrosis,
nuclear
vacuolization,
observing
sections.
Lysozyme
enzyme
activity
increased,
whereas
catalase
alkaline
phosphatase
activities
decreased.
The
transcriptome
results
control
high-concentration
(0.28
μg/L)
groups
showed
there
697
differentially
expressed
genes,
390
upregulated
307
downregulated
genes.
These
genes
significantly
enriched
oxidation-reduction,
ferroptosis,
steroid
biosynthesis,
apoptosis
pathways.
summary,
found
induces
metabolic
disorders
P.
olivaceus
leads
inflammation.
fish
body
resists
such
through
complex
regulatory
network.
experimental
provide
theoretical
reference
for
safe
use
