Advances in Clinical Medicine, Journal Year: 2024, Volume and Issue: 14(12), P. 1629 - 1637
Published: Jan. 1, 2024
Language: Английский
Nature Reviews Urology, Journal Year: 2025, Volume and Issue: unknown
Published: Jan. 28, 2025
Language: Английский
Citations
2
BMC Medicine, Journal Year: 2024, Volume and Issue: 22(1)
Published: Sept. 11, 2024
Language: Английский
Citations
11
Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)
Published: Jan. 10, 2024
Abstract Several studies have reported an increased risk of chronic kidney disease (CKD) outcomes after long-term exposure (more than 1 year) to particulate matter with aerodynamic diameter ≤ 2.5 µm (PM ). However, the conclusions remain inconsistent. Therefore, we conducted this meta-analysis examine association between PM and CKD outcomes. A literature search was in PubMed, Scopus, Cochrane Central Register Controlled trials, Embase for relevant published until August 10, 2023. The main were incidence prevalence as well end-stage (ESKD). random-effect model meta‐analyses used estimate each outcome among studies. Twenty two identified, including 14 cohort studies, 8 cross-sectional a total 7,967,388 participants. This revealed that 10 μg/m 3 increment significantly associated risks both [adjusted odds ratio (OR) 1.31 (95% confidence interval (CI) 1.24 1.40), adjusted OR CI 1.03 1.67), respectively]. In addition, relationship ESKD is suggestive but not conclusive (adjusted 1.16; 95% 1.00 1.36). had consistent across all subgroups adjustment variables. Our study observed CKD. more dedicated are required show causation warrants urgent action on mitigate global burden
Language: Английский
Citations
9
Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 290, P. 117726 - 117726
Published: Jan. 1, 2025
Myeloperoxidase (MPO) is an oxidative stress biomarker, with elevated MPO levels linked to chronic kidney disease (CKD) progression. Metal exposure a risk factor for CKD, and also correlated expression, specific genotypes expression. Therefore, we examined whether plasma or polymorphisms were explored these factors modified associations between CKD metal concentrations. Accordingly, recruited 395 age- sex-matched controls 215 patients (persistent estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m2 minimum of 12 weeks without hemodialysis). We identified no several CKD. However, after multivariate adjustment, concentrations positively odds ratio (OR) = 5.87 (95 % confidence interval [CI]: 3.14-10.96). Significant additive interactions observed high blood cadmium (Cd) lead (Pb) levels, total urinary arsenic (As), low selenium (Se) concentrations, leading increased ORs significant synergy indices recorded. High showed multiplicative Pb Se which the (p-values 0.005 0.009, respectively). Our study first show interaction concentration metals affecting OR
Language: Английский
Citations
1
Ecotoxicology and Environmental Safety, Journal Year: 2023, Volume and Issue: 257, P. 114922 - 114922
Published: April 17, 2023
Numerous studies have explored the association of air pollution with asthma but yielded conflicting results. The exact role in incidence adult-onset and whether this effect is modified by genetic risk, lifestyle, or their interaction remain uncertain.We conducted a prospective cohort study on 298,738 participants (aged 37-73 years) registered UK Biobank. Cox proportional hazard models were used to evaluate pollution, including particulate matter (PM2.5, PMcoarse, PM10), nitrogen dioxide (NO2), oxides (NOx), incidence. We constructed risk lifestyle scores, assessed impact was susceptibility factors, evaluated identified interactions.We found that each interquartile range increase annual concentrations PM2.5, NO2, NOx related 1.04 (95% confidence interval [CI]: 1.01, 1.08), CI: 1.00, 1.03 1.06) times asthma, respectively. size greater among subpopulations low unfavorable lifestyles. also an additive not asthma.Our analyses show increases risk. These findings emphasize need for integrated interventions environmental government as well adherence healthy lifestyles prevent asthma.
Language: Английский
Citations
14
The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 946, P. 174069 - 174069
Published: June 21, 2024
Language: Английский
Citations
4
Therapeutics and Clinical Risk Management, Journal Year: 2025, Volume and Issue: Volume 21, P. 1 - 13
Published: Jan. 1, 2025
Background: The negative impacts of particulate matter with an aerodynamic diameter 2.5 μm or less (PM ) are well known. Patients undergoing maintenance hemodialysis (HD) have significantly higher blood cadmium levels (BCLs) than healthy individuals. As elemental can be found in the PM particle fraction, we conducted this study to assess effect environmental exposure and other clinical variables on BCLs HD patients. Patient Methods: This cross-sectional included 754 hD patients who had previously participated a BCL study. Demographic, hematological, biochemical dialysis-related data were collected for analysis. For each patient, mean concentrations living environment during previous 12 24 months recorded analyzed. Results: Of all patients, median was 0.36 μg/L (range: 0.21, 0.79 μg/L). concentration 28.45 ± 3.57 μg/m 3 29.81 3.47 months, respectively. From multivariate linear regression analysis, log positively associated months. In addition, number days above standard level Moreover, according tertiles daily normal limit highest exhibited those two patient groups. Conclusion: Chronic is -bound may contribute harmful effects health population. Further studies needed confirm these observations explore underlying mechanisms. Keywords: air pollution, cadmium, hemodialysis, matter,
Language: Английский
Citations
0
Environmental Pollution, Journal Year: 2024, Volume and Issue: 358, P. 124509 - 124509
Published: July 4, 2024
The impact of environmental risk factors on chronic kidney disease (CKD) remains unclear. This systematic review aims to provide an overview the literature association between general external exposome and CKD development or progression. We searched MEDLINE EMBASE for case-control cohort studies, that investigated with a change in eGFR albuminuria, diagnosis progression CKD, CKD-related mortality. bias included studies was assessed using Newcastle-Ottawa Scale. Summary effect estimates were calculated random-effects meta-analyses. Most 66 focused air pollution (n = 33), e.g. particulate matter (PM) nitric oxides (NOx), heavy metals 21) lead cadmium. Few chemicals 7) built 5). No articles other environment such as noise, food supply, urbanization found. PM2.5 exposure associated increased end-stage incidence, but not There mixed evidence regarding NO
Language: Английский
Citations
3
Environmental Research Letters, Journal Year: 2024, Volume and Issue: 19(3), P. 034012 - 034012
Published: Feb. 6, 2024
Abstract Limited studies have examined associations of gaseous air pollutants exposure with chronic kidney disease (CKD) in Europe. This study aimed to calculate the relationships between long-term ambient sulfur dioxide (SO 2 ), carbon monoxide (CO), ozone (O 3 and benzene CKD UK. We included 502 369 participants from UK biobank cohort. Associations SO , CO, O were estimated using Co x proportional hazards model. The shape exposure-response association each pollutant was then depicted constrained health impact function. finally incidence attributable by linking constructed 2019 Global Burden Disease data. Our results suggested high days (daily max 8 hr concentration > 120 µ g m −3 positively associated risk incident CKD. hazard ratios (HRs) for 1.058 (95% CI: 1.039–1.078), 1.003 1.001–1.005), 1.619 (1.433–1.829) every 1 μ increase concentration, respectively. For days, HR 1.044 1.032–1.056) d increase, but correlation did not reach statistical significance time-varying increased non-linearly increasing linearly benzene. that 7.9%, 16.0%, 8.0% cases 2021 could be attributed benzene, concluded all risk. findings highlight importance considering pollution while making strategies targeting on management.
Language: Английский
Citations
2
Journal of Biochemical and Molecular Toxicology, Journal Year: 2023, Volume and Issue: 38(1)
Published: Dec. 13, 2023
Abstract Although epidemiological studies have evaluated the association between ambient air pollution and chronic kidney disease (CKD), results remain mixed. To clarify nature of association, we conducted a comprehensive systematic review meta‐analysis to assess global relationship CKD. The Web Science, PubMed, Embase Cochrane Library databases systematically were searched for published up July 2023 included 32 that met specific criteria. random effects model was used derive overall risk estimates each pollutant. estimated odds ratio (ORs) CKD 1.42 (95% confidence interval [CI]: 1.31–1.54) 10 μg/m 3 increase in PM 2.5 ; 1.20 CI: 1.14–1.26) 1.07 1.05–1.09) NO 2 1.03 1.02–1.03) X 1.01–1.12) 1 ppb SO 1.00–1.05) 0.1 ppm CO. Subgroup analysis showed this effect varied by gender ratio, age, study design, exposure assessment method, income level. Furthermore, , had negative on even within World Health Organization‐recommended acceptable concentrations. Our further confirmed adverse These findings can contribute enhance awareness importance reducing among public health officials policymakers.
Language: Английский
Citations
5