Selenium deficiency exacerbates ROS/ER stress mediated pyroptosis and ferroptosis induced by bisphenol A in chickens thymus

Journal of Environmental Sciences, Journal Year: 2024, Volume and Issue: 148, P. 13 - 26

Published: Jan. 21, 2024

Language: Английский

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Uridine diphosphate glucuronosyltransferase 1A1 prevents the progression of liver injury

World Journal of Gastroenterology, Journal Year: 2024, Volume and Issue: 30(9), P. 1189 - 1212

Published: March 5, 2024

BACKGROUND Uridine diphosphate glucuronosyltransferase 1A1 (UGT1A1) plays a crucial role in metabolizing and detoxifying endogenous exogenous substances. However, its contribution to the progression of liver damage remains unclear. AIM To determine mechanism UGT1A1 progression. METHODS We investigated relationship between expression injury through clinical research. Additionally, impact on was analyzed mouse model study. RESULTS Patients with gene mutations showed varying degrees damage, while patients acute-on-chronic failure (ACLF) exhibited relatively reduced levels protein as compared chronic hepatitis. This suggests that low may be associated damage. In models induced by carbon tetrachloride (CCl4) concanavalin A (ConA), hepatic were found increased. mice lipopolysaccharide or steatosis-mediated liver-injury progression, decreased, which is consistent observations ACLF. knockout exacerbated CCl4- ConA-induced injury, hepatocyte apoptosis necroptosis mice, intensified endoplasmic reticulum (ER) stress oxidative stress, disrupted lipid metabolism. CONCLUSION upregulated compensatory response during interference this upregulation process worsen injury. reduces ER metabolism disorder, thereby mitigating necroptosis.

Language: Английский

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Integrated metabolomics and phosphoproteomics reveal the protective role of exosomes from human umbilical cord mesenchymal stem cells in naturally aging mouse livers

Experimental Cell Research, Journal Year: 2023, Volume and Issue: 427(1), P. 113566 - 113566

Published: April 1, 2023

Language: Английский

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Abamectin Causes Neurotoxicity in Zebrafish Embryos

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(1), P. 349 - 349

Published: Jan. 3, 2025

Abamectin is an insecticide, miticide and nematicide that has been extensively used in agriculture for many years. The excessive use of abamectin inevitably pollutes water soil might even cause adverse effects on aquatic biota. However, it currently unclear how exposure causes neurotoxicity organisms. Herein, the early neural system development was assessed zebrafish embryos following exposure. After treatment with a concentration gradient (0.055, 0.0825, 0.11 mg/L), survival rate, average heart pericardial edema area yolk sac were all documented (96 hpf). It found after exposure, embryonic brain impaired, motor behaviors also affected. fluorescence intensity reduced transgenic (Eno2: GFP). activities acetylcholinesterase (AChE) ATPase decreased, expression neurodevelopment-related genes, such as sox10, gap43, grin1b, abat, gad1b, grin2b, nestin glsa, inhibited embryo abamectin. Furthermore, reactive oxygen species (ROS) triggered upon to along accumulation ROS, eventually resulting neuroapoptosis developing brain. In conclusion, neurodevelopmental toxicity caused by oxidative stress-induced apoptosis

Language: Английский

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Nanoscale Effects in the Room-Temperature UV–Visible Photoluminescence from Silica Particles and Its Cancer Cell Imaging

Bioconjugate Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Silica nano/microparticles have generated significant interest for the past decades, emerging as a versatile material with wide range of applications in photonic crystals, bioimaging, chemical sensors, and catalysis. This study focused on synthesizing silica ranging from 20 nm to 1.2 μm using Stöber modified methods. The particles exhibited photoluminescence emission across UV-visible range, specifically UV (∼290, ∼327, ∼339, ∼377 nm), blue (∼450 green (∼500 yellow (∼576 red (∼634 nm) electromagnetic spectrum. These emissions are due radiative relaxation processes involving oxygen-deficient centers arising unrelaxed oxygen vacancies, strong interacting surface silanols, 2-fold coordinated silicon, self-trapped excitons, hydrogen-related species, strain-induced defects, nonbridging hole excited via two-photon single photon absorption. increased PL intensity decreasing particle size was attributed higher concentrations defect sites case smaller-sized particles. MTT assay, AO/EB staining, DCFDA assay confirmed biocompatible nature HepG2 cell line. In addition, viability normal line (HEK293) also showed no substantial death. Successful bioimaging cells performed nano/microparticles, which fluorescence, along Hoechst33258 dye. Even though nm-sized emission, sized above better fluorescence cells, citing their potential vitro applications.

Language: Английский

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Prrx1 promotes mesangial cell proliferation and kidney fibrosis through YAP in diabetic nephropathy

Journal of Pharmaceutical Analysis, Journal Year: 2025, Volume and Issue: unknown, P. 101247 - 101247

Published: Feb. 1, 2025

Language: Английский

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Sappanone A mitigates cognitive impairment and oxidative stress through modulation of alpha7 nicotinic acetylcholine receptor in rats with trimethyltin-induced Alzheimer’s disease-like condition

Pharmacological Research - Modern Chinese Medicine, Journal Year: 2025, Volume and Issue: unknown, P. 100619 - 100619

Published: April 1, 2025

Language: Английский

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The Mechanical Role of YAP/TAZ in the Development of Diabetic Cardiomyopathy

Current Issues in Molecular Biology, Journal Year: 2025, Volume and Issue: 47(5), P. 297 - 297

Published: April 23, 2025

Diabetic cardiomyopathy (DCM) begins with a subclinical stage featuring cardiac hypertrophy, fibrosis, and disrupted signaling. These changes, especially fibrosis stiffness, often lead to clinical heart failure. The mechanism involves metabolic dysregulation, oxidative stress, inflammation, leading damage dysfunction. During the progression of disease, myocardium senses surrounding mechanical cues, including extracellular matrix properties, tensile tension, shear pressure load, which significantly influence pathological remodeling through mechanotransduction. At molecular level, mechanisms by cues are sensed transduced mediate myocardial in DCM remain unclear. mechanosensitive transcription factors YAP TAZ fill this gap. This article reviews latest findings how perceive wide range from stress stiffness. We focus on these relayed cytoskeleton nucleus, where they trigger downstream gene expression. Here, we review recent progress crucial role mechanotransduction changes observed DCM, mitochondrial dysfunction, cell death.

Language: Английский

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Composition, Release, and Transformation of Earthworm Tissue-Bound Residues of Tetrabromobisphenol A in Soil

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 18, 2024

Earthworms accumulate organic pollutants to form earthworm tissue-bound residues (EBRs); however, the composition and fate of EBRs in soil remain largely unknown. Here, we investigated tetrabromobisphenol A (TBBPA)-derived for 250 days using a 14C-radioactive isotope tracer geophagous Metaphire guillelmi. The TBBPA were rapidly transformed into nonextractable (NERs), mainly sequestered ester-linked residues. After incubation, 4.9% initially applied mineralized 69.3% released extractable containing its transformation products (TPs, generated via debromination, O-methylation, skeletal cleavage). Soil microbial activity autolytic enzymes earthworms jointly contributed release process. In their full-life period, overall retained 24.1% TPs thus prolonged persistence these pollutants. Our study explored, first time, pollutant-derived indicated that decomposition may cause potential environmental risks concern, which should be included both risk assessment remediation earthworms.

Language: Английский

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The Toxoplasma protein phosphatase 6 catalytic subunit (TgPP6C) is essential for cell cycle progression and virulence

PLoS Pathogens, Journal Year: 2023, Volume and Issue: 19(12), P. e1011831 - e1011831

Published: Dec. 13, 2023

Protein phosphatases are post-translational regulators of Toxoplasma gondii proliferation, tachyzoite-bradyzoite differentiation and pathogenesis. Here, we identify the putative protein phosphatase 6 (TgPP6) subunits T . elucidate their role in parasite lytic cycle. The catalytic subunit TgPP6C regulatory TgPP6R likely form a complex whereas predicted structural TgPP6S, with low homology to human PP6 subunit, does not coassemble TgPP6R. Functional studies showed that essential for growth replication. ablation significantly reduced synchronous division parasite’s daughter cells during endodyogeny, resulting disordered rosettes. Moreover, six conserved motifs were required efficient endodyogeny. Phosphoproteomic analysis revealed predominately altered phosphorylation status proteins involved regulation cell Deletion attenuated virulence mice. Immunization mice TgPP6C-deficient type I RH strain induced protective immunity against challenge lethal dose or PYS tachyzoites Pru cysts. Taken together, results show contributes division, replication pathogenicity

Language: Английский

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