Associations of Sperm Mitochondrial DNA Copy Number with Concentrations of Urinary Cadmium and Selenium DOI Creative Commons
Cindy Rahman Aisyah, Yuki Mizuno, Momoka Masuda

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: April 5, 2023

Abstract Elevated sperm mitochondrial DNA copy number (mtDNAcn) is associated with damage to and poorer measures of semen quality. Exposure cadmium (Cd) can increase oxidative stress mitochondria. The adverse effects Cd potentially be reduced by sufficient selenium (Se). objective this study was examine the associations between mtDNAcn urinary concentrations Cd, Se, Cd/Se molar ratio. Participants were recruited from patients who sought infertility treatment at two hospitals in Japan. Urine specimens self-administered questionnaires collected on day recruitment. Sperm measured extracted multiplex real-time qPCR. Urinary Se using inductively coupled plasma mass spectrometry. weights calculated obtain Linear regression used predict after adjusting for age, BMI, smoking, drinking, exercise, varicocele, hospital showed statistically insignificant (β = 0.13, 95% CI -0.18, 0.44), concentration -0.09, -0.54, 0.35), ratio 0.12, -0.13, 0.37). current did not find evidence or being related mtDNAcn.

Language: Английский

Per- and Polyfluoroalkyl Substances in Semen Associated with Repeated Measures of Semen Quality in Healthy Adult Men DOI
Fengjiang Sun,

Yijian Lin,

An Pan

et al.

Environmental Science & Technology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

Although epidemiological studies have explored the association between poly- and perfluoroalkyl substances (PFAS) concentrations semen quality, existing findings are often inconsistent. Our work aimed to explore of PFAS in plasma with repeated measures quality parameters healthy adults. Plasma was collected at initial recruitment least once within five predetermined intervals during an approximately 3-month period. Semen volume, concentration, motility, total sperm count were measured each specimen. individual samples (n = 1252) pooled 1019) from multiple collections (or a single sample if no collection available). The results reveal seminal perfluorooctanoic acid, perfluorooctanesulfonic perfluorohexanesulfonic 6:2 chlorinated polyfluoroalkyl ether sulfonate significantly associated decreased progressive motility while positively concentration count. By contrast, null associations observed quality. study provides evidence that exposure may affect male fertility should be for precise assessment impact on reproductive performances.

Language: Английский

Citations

1
Associations between seminal plasma metal mixture and semen quality: A metabolome-mediated case-control study DOI
Shujie Zhao,

Wanting Lu,

Guanxiang Yuan

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2025, Volume and Issue: 297, P. 118257 - 118257

Published: May 3, 2025

Language: Английский

Citations

0
The Association Between the Levels of Oxidative Stress Indicators (MDA, SOD, and GSH) in Seminal Plasma and the Risk of Idiopathic Oligo-asthenotera-tozoospermia: Does Cu or Se Level Alter the Association? DOI
Tao Yin, Xinyu Yue, Qian Li

et al.

Biological Trace Element Research, Journal Year: 2023, Volume and Issue: 202(7), P. 2941 - 2953

Published: Oct. 7, 2023

Language: Английский

Citations

8
Simultaneous Quantification of 30 Elements in the Mineral Chinese Medicine Quartz Album by ICP-MS for the Identification of Different Geogenesis DOI Creative Commons
Chenyu Xu, Xingyu Zhu, Yu‐Lu Ma

et al.

Pharmacognosy Magazine, Journal Year: 2023, Volume and Issue: 19(3), P. 592 - 602

Published: June 27, 2023

Background Quartz album is one of the mineral drugs commonly used in Chinese medicine. Different geogenesis led to differences its composition and thus affected clinical efficacy. Mineral medicines are mainly composed inorganic elements, including some heavy metals harmful so their quality control crucial safety. Materials Methods In this study, contents 30 elements 13 batches different origins were determined by inductively coupled plasma mass spectrometry (ICP-MS). Multiple chemometrics distinguish geogenesis. Results We found that top order content as follows: Al>Fe>Ca>K>Mg>Ti>Mn, all with greater than 100 µg/g. addition, ranges Pb, Cd, As, Hg, Cu 1.603–637.705, 0.011–1.387, 0.348–41.298, 0.033–10.877, 0.808–86.482 µg/g, respectively. albums produced Fengyang County, Anhui Province, had lowest metals. Correlation analysis showed there was a strong correlation among samples. Chemometrics analyze elemental content, results models be consistent could between Conclusion This study provided reference for safety application album.

Language: Английский

Citations

4
Blood trihalomethane and urinary haloacetic acid concentrations in relation to hypertension: An observational study among 1162 healthy men DOI
Guangming Li,

Shiyu Xu,

Carmen Messerlian

et al.

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 477, P. 135411 - 135411

Published: Aug. 6, 2024

Language: Английский

Citations

1
Association between Sperm Mitochondrial DNA Copy Number and Concentrations of Urinary Cadmium and Selenium DOI Creative Commons
Cindy Rahman Aisyah, Yuki Mizuno, Momoka Masuda

et al.

Biological Trace Element Research, Journal Year: 2023, Volume and Issue: 202(6), P. 2488 - 2500

Published: Sept. 27, 2023

Abstract Elevated sperm mitochondrial DNA copy number (mtDNAcn) is associated with damage to and poorer measures of semen quality. Exposure cadmium (Cd) can increase oxidative stress mitochondria. The adverse effects Cd potentially be reduced by sufficient selenium (Se). objective this study was examine the associations between mtDNAcn urinary concentrations Se, as well Cd/Se molar ratio. Participants were recruited from patients who sought infertility treatment at two hospitals in Japan. Urine specimens self-administered questionnaires collected on day recruitment. Sperm measured extracted multiplex real-time qPCR. Urinary Se using inductively coupled plasma mass spectrometry, their weights calculated obtain Linear regression used estimate after adjusting for age, body index, smoking, drinking, exercise, varicocele, hospital showed statistically insignificant creatinine-adjusted (β = 0.13, 95% CI −0.18, 0.44) −0.09, −0.54, 0.35), ratio 0.12, −0.13, 0.37). current found no evidence an association or

Language: Английский

Citations

1
Association of urinary and seminal plasma vanadium concentrations with semen quality: A repeated-measures study of 1135 healthy men DOI Creative Commons
Heng‐Gui Chen,

Ping Wu,

Xiao-Feng Zheng

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 272, P. 116075 - 116075

Published: Feb. 6, 2024

Although animal studies have shown the reproductive toxicity of vanadium, less is known about its effects on semen quality in humans. Among 1135 healthy men who were screened as potential donors, we investigated relationships with urinary and seminal plasma vanadium levels via inductively coupled plasma-mass spectrometry (ICP-MS). Spearman rank correlation tests linear regression models used to assess correlations between average within-individual pooled concentrations (n = 1135). We utilized mixed-effects evaluate associations 1135) repeated sperm parameters 5576). Seminal not significantly correlated (r 0.03). After adjusting for possible confounders, observed inverse total count, volume, concentration (all P values trend < 0.05). Specifically, subjects highest (vs. lowest) tertile had - 11.3% (-16.4%, -5.9%), 11.1% (-19.1%, -2.4%), 20.9% (-29.0%, -11.8%) lower concentration, respectively; moreover, appeared be negatively associated motility. These showed monotonically decreasing dose-response patterns restricted cubic spline analyses. Our results demonstrated a poor elevated urine may adversely related male quality.

Language: Английский

Citations

0
Associations of Sperm Mitochondrial DNA Copy Number with Concentrations of Urinary Cadmium and Selenium DOI Creative Commons
Cindy Rahman Aisyah, Yuki Mizuno, Momoka Masuda

et al.

Research Square (Research Square), Journal Year: 2023, Volume and Issue: unknown

Published: April 5, 2023

Abstract Elevated sperm mitochondrial DNA copy number (mtDNAcn) is associated with damage to and poorer measures of semen quality. Exposure cadmium (Cd) can increase oxidative stress mitochondria. The adverse effects Cd potentially be reduced by sufficient selenium (Se). objective this study was examine the associations between mtDNAcn urinary concentrations Cd, Se, Cd/Se molar ratio. Participants were recruited from patients who sought infertility treatment at two hospitals in Japan. Urine specimens self-administered questionnaires collected on day recruitment. Sperm measured extracted multiplex real-time qPCR. Urinary Se using inductively coupled plasma mass spectrometry. weights calculated obtain Linear regression used predict after adjusting for age, BMI, smoking, drinking, exercise, varicocele, hospital showed statistically insignificant (β = 0.13, 95% CI -0.18, 0.44), concentration -0.09, -0.54, 0.35), ratio 0.12, -0.13, 0.37). current did not find evidence or being related mtDNAcn.

Language: Английский

Citations

0