Molecular Neurobiology, Journal Year: 2023, Volume and Issue: 60(8), P. 4828 - 4841
Published: May 12, 2023
Language: Английский
Neurobiology of Disease, Journal Year: 2023, Volume and Issue: 187, P. 106314 - 106314
Published: Oct. 1, 2023
Poly (ADP-ribose) polymerase-1 (PARP-1) is the most extensively studied member of PARP superfamily, with its primary function being facilitation DNA damage repair processes. Parthanatos a type regulated cell death cascade initiated by PARP-1 hyperactivation, which involves multiple subroutines, including accumulation ADP-ribose polymers (PAR), binding PAR and apoptosis-inducing factor (AIF), release AIF from mitochondria, translocation AIF/macrophage migration inhibitory (MIF) complex, massive MIF-mediated fragmentation. Over past few decades, role in central nervous system health disease has received increasing attention. In this review, we discuss biological functions neural proliferation differentiation, memory formation, brain ageing, epigenetic regulation. We then elaborate on involvement PARP-1-dependant parthanatos various neuropathological processes, such as oxidative stress, neuroinflammation, mitochondrial dysfunction, excitotoxicity, autophagy damage, endoplasmic reticulum (ER) stress. Additional highlight contains PARP-1's implications initiation, progression, therapeutic opportunities for different neurological illnesses, neurodegenerative diseases, stroke, autism spectrum disorder (ASD), sclerosis (MS), epilepsy, neuropathic pain (NP). Finally, emerging insights into repurposing inhibitors management diseases are provided. This review aims to summarize exciting advancements critical disorders, may open new avenues options targeting or parthanatos.
Language: Английский
Citations
28
Oncogene, Journal Year: 2024, Volume and Issue: 43(11), P. 821 - 836
Published: Jan. 27, 2024
Abstract Triple-negative breast cancer (TNBC) cells are in a more hypoxic and starved state than non-TNBC cells, which makes TNBC always maintain high autophagy levels. Emerging evidence has demonstrated that circular RNAs (circRNAs) involved the progress of tumorigenesis. However, regulation functions autophagy-induced circRNAs remain unclear. In our study, autophagy-responsive circRNA candidates under amino acid were identified by RNA sequencing. The results showed circEGFR expression was significantly upregulated autophagic cells. Knockdown inhibited derived from exosomes induced recipient tumor microenvironment. vitro vivo functional assays as an oncogenic TNBC. Clinically, positively associated with lymph node metastasis. CircEGFR plasma-derived patients compared healthy people. Mechanistically, facilitated translocation Annexin A2 (ANXA2) toward plasma membrane led to release Transcription Factor EB (a transcription factor autophagy-related proteins, TFEB) ANXA2-TFEB complex, causing nuclear TFEB, thereby promoting Meanwhile, acted ceRNA directly binding miR-224-5p miR-224-5p, weakened suppressive role miR-224-5p/ATG13/ULK1 axis on autophagy. Overall, study demonstrates key autophagy, malignant progression, metastasis These indicate is potential diagnosis biomarker therapeutic target for
Language: Английский
Citations
10
Tissue and Cell, Journal Year: 2024, Volume and Issue: 89, P. 102424 - 102424
Published: June 9, 2024
Sepsis-induced cardiomyopathy (SIC) leads to high mortality and has no effective treatment strategy. Atractylenolide Ⅰ (AT-I) is a sesquiterpene lactone compound possesses various biological activities such as anti-inflammatory organ protection. This study was designed explore the role mechanism of AT-I in SIC. CCK-8 assay used assess viability AT-I-treated RAW 264.7 cells immunofluorescence detect M1 marker CD86. The expressions markers Cox2, iNOS CD11b PARP1/NLRP3 signaling pathway-related proteins were detected using western blot. transfection efficiency oe-PARP1 examined with RT-qPCR ROS activity H9c2 DCFH-DA blot inflammation- oxidative stress-related proteins. apoptosis flow cytometry present found that inhibited LPS-induced polarization through downregulation pathway, thereby inhibiting stress cells. In conclusion, might be promising therapeutic agent for SIC by suppressing macrophage modulation pathway.
Language: Английский
Citations
5
Brain Research, Journal Year: 2024, Volume and Issue: 1838, P. 148988 - 148988
Published: May 8, 2024
Language: Английский
Citations
3
Toxics, Journal Year: 2024, Volume and Issue: 12(4), P. 258 - 258
Published: March 30, 2024
Natural pyrethrins (NPs), one kind of bio-pesticide, have been widely used in organic agriculture and ecological environment studies. Studies shown that NPs may affect the metabolism rat liver human hepatocytes; nevertheless, toxic effects on related mechanisms are still incompletely understood. In this research, we utilized three types cells to investigate mechanism NPs’ induction oxidative stress. The results showed exhibit noteworthy cytotoxic cells. These characterized by LDH release, mitochondrial collapse, an increased production ROS MDA content, subsequently activating Kelch-like ECH-associated protein 1/Nuclear factor erythroid 2- 2 (Keap1/Nrf-2) pathway. inhibitor N-acetyl-L-cysteine (NAC) can alleviate ROS/Nrf2-mediated addition, siRNA knockdown Nrf-2 exacerbated injury, including production, inhibited cell viability. summary, ROS-mediated Keap1/Nrf-2 pathway could be important regulator NP-induced damage cells, which further illustrates hepatotoxicity thereby contributes scientific basis for exploration.
Language: Английский
Citations
0
International Immunopharmacology, Journal Year: 2024, Volume and Issue: 143, P. 113608 - 113608
Published: Nov. 15, 2024
Language: Английский
Citations
0
Molecular Neurobiology, Journal Year: 2023, Volume and Issue: 60(8), P. 4828 - 4841
Published: May 12, 2023
Language: Английский
Citations
1