Emerging role and clinical applications of circular RNAs in human diseases

Functional & Integrative Genomics, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 28, 2025

Language: Английский

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Neuroinflammation in Parkinson’s disease: focus on the relationship between miRNAs and microglia

Frontiers in Cellular Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: July 26, 2024

Parkinson’s disease (PD) is a prevalent neurodegenerative disorder that affects the central nervous system (CNS). Neuroinflammation crucial factor in pathological advancement of PD. PD characterized by presence activated microglia and increased levels proinflammatory factors, which play role its pathology. During immune response PD, regulation significantly influenced microRNA (miRNA). The excessive activation microglia, persistent neuroinflammation, abnormal polarization macrophages brain can be attributed to dysregulation certain miRNAs. Additionally, there are miRNAs possess ability inhibit neuroinflammation. miRNAs, small non-coding epigenetic regulators, have modulate microglial activity both normal conditions. They also significant impact on promoting communication between neurons microglia.

Language: Английский

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Microglia-derived sEV: Friend or foe in the pathogenesis of cognitive impairment

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown, P. 111287 - 111287

Published: Feb. 1, 2025

Language: Английский

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Recent advances on the role of exosomes in neurodegenerative diseases

Chinese Journal of Chromatography, Journal Year: 2025, Volume and Issue: 43(5), P. 487 - 497

Published: May 1, 2025

Exosomes are nano-sized, lipid bilayer vesicles secreted by cells. They carry essential bioactive molecules, such as proteins, nucleic acids, and lipids, widely present in bodily fluids including blood cerebrospinal fluid. transfer molecules to target cells through various mechanisms, endocytosis, ligand-receptor interactions, or direct membrane fusion, play crucial roles intercellular communication, facilitating information exchange, maintaining nerve-cell function, participating immune responses, providing nutritional support. significantly promote signal transmission communication the central nervous system involved pathogenesis development of diseases spread pathological regulating neuroinflammation, deposition proteins. Therefore, exosomes key occurrence neurodegenerative diseases, their contents, especially proteins miRNAs, specific for given physiological states relatively stable during extraction analysis. Hence, ideal tools diagnosing staging courses, assisting prognosis. This article further explores derived from blood, saliva, urine, fluid potential diagnostic biomarkers diseases. As natural drug-delivery systems, have advantages biocompatibility, ability cross biological barriers, specificity, stability, containing therapeutic which can effectively improve precision efficacy drug delivery reduce side effects, making them an carrier delivering drugs system. hold great diagnosis treatment systematically reviews latest advances exosome research directed toward focusing on played disease pathogenesis, progression, diagnosis, treatment, with aim theoretical support a reference early these

Language: Английский

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Circular RNA and Neuropsychiatric Practice: A Scoping Review of the Literature and Discussion of Unmet Clinical Needs

Journal of Neuropsychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: May 19, 2025

Circular RNA (circRNA) is a recently characterized species of that highly enriched in the human brain, differentially expressed neuropsychiatric disorders, and readily detectable peripheral circulation. These characteristics make circRNA an attractive candidate biomarker for illness suggest it as potential missing link understanding specific biological underpinnings illness. In this scoping review, authors summarize literature on disorders add clinical context. The searched PubMed, PsycInfo, Embase, Cochrane Database Systematic Reviews, Central Register Controlled Trials articles describing research mental published or after 2012. included peer-reviewed studies with substantive discussions participants cell lines. Only written English translations were considered. Seventy-eight met authors' inclusion criteria. Common serious illnesses well represented among these studies, including schizophrenia, major depressive disorder, neurocognitive disorder. Many identified altered levels blood brain regions both sensitive to disorders. Few discussed role circRNA-based diagnostic tests might play practice, prognostic, therapeutic, monitoring biomarkers was limited. Although circRNAs have change treatment field would benefit from more clinician involvement area identify address urgent needs.

Language: Английский

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Regulation of nerve cells and therapeutic potential in central nervous system injury using microglia-derived exosomes

Neuroscience, Journal Year: 2024, Volume and Issue: 563, P. 84 - 92

Published: Nov. 8, 2024

Language: Английский

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