Effects of dietary sources and personal care products on paraben exposure in young Korean adults: A crossover intervention study

Chemosphere, Journal Year: 2025, Volume and Issue: 374, P. 144209 - 144209

Published: Feb. 17, 2025

Language: Английский

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Endocrine-disrupting chemicals and male reproductive health

Fertility and Sterility, Journal Year: 2023, Volume and Issue: 120(6), P. 1138 - 1149

Published: Oct. 11, 2023

Language: Английский

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Relationship between the level of mixed chemicals in male urine and the prevalence of male cancers, especially prostate cancer

Frontiers in Public Health, Journal Year: 2025, Volume and Issue: 13

Published: March 12, 2025

Objectives The aim of this study was to investigate the relationship between mixed chemicals in urine and prevalence cancers men. Methods A total 1,068 male subjects were included study. Analyses performed by several analytical methods ensure stability results: one-way analysis, WQS Qgcomp BKMR Restricted Cubic Spline (RCS). Results In final adjusted model, each 1 increase ln-transformed BPS increased risk developing cancerous prostate 49% (95% CI: 1.00–2.20). results multiple sensitivity analyses showed that positively correlated with cancer quartile index associated a 78% (OR: 1.78, 95% 1.10–2.87) 148% 2.48, 1.07–5.71) cancer. Each 59% 1.59, 1.09–2.33) cancers, 105% 2.05, 1.04–4.06) Conclusion conclusion, positive correlation concentrations three groups men, as well

Language: Английский

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Fetal exposure to a mixture of endocrine‐disrupting chemicals and biomarkers of male fecundity: A population‐based cohort study

Andrology, Journal Year: 2025, Volume and Issue: unknown

Published: April 12, 2025

Fetal exposure to endocrine-disrupting chemicals (EDCs) has been associated with reduced male fecundity, but few studies considering chemical mixtures. We assessed the association between fetal a mixture of EDCs and biomarkers fecundity in young adulthood. The study population comprised 841 adult males enrolled Programming Semen Quality cohort, established as offspring sub-cohort within Danish National Birth Cohort. Maternal blood samples were analyzed for concentrations per- polyfluoroalkyl substances (PFAS), phthalate metabolites, triclosan. used quantile g-computation estimate change semen characteristics, testicular volume, reproductive hormone levels 95% confidence intervals (CI) per one-quartile increase all three mixtures; an overall mixture, PFAS non-persistent mixture. was 4.0 million/mL lower sperm concentration (95% CI: -9.1, 1.1), 16.1 million total count -33.8, 1.6), 0.5 mL smaller volume -1.2, 0.3), 5% higher proportion non-progressive immotile spermatozoa 0.99, 1.11), 7% FSH 1.16), limited precision. Effect sizes greatest magnitude count. observed somewhat similar associations no Results suggest that may be adversely several findings are also compatible null associations. These associations, if true, appeared driven by PFAS, misclassification due single measurement metabolites triclosan have attenuated results.

Language: Английский

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Advances in plant essential oils and drug delivery systems for skincare

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: April 17, 2025

Essential oils, often referred to as "liquid gold," are renowned for their broad biological activity. Ancient Egyptians used essential oils' antibacterial and antiseptic effects preserve mummies, ancient Greeks olive oil sun protection, Chinese oils treat wounds. When applied the facial skin, potent anti-inflammatory, antioxidant, pharmacological characteristics provide various benefits, including sunscreen, skin-whitening, anti-aging effects. This paper aims summarize application of plant in skin whitening, antioxidant recent years, deeply analyzes internal relationship between modern drug delivery system, expounds how overcome limitations through specific enhance its activity stability, realize sustained release reduce potential toxicity, also discusses positive on brain function olfactory pathway, emphasizes possible safety risks use oil, puts forward corresponding suggestions use. Using keywords such "essential oils," "antioxidant," "anti-tyrosinase," Antibacterial Effects anti-inflammatory," "anti-anxiety," "drug carrier systems," a comprehensive search was conducted PubMed, CNKI, Baidu, Wanfang databases articles from past 5 years. Further screening performed select studies demonstrating efficacy topical or external application. Various showed strong oxidants, agents, anti-inflammatory skin-whitening agents. Combined with new it not only enhances but reduces inherent defects volatility, irritation, has targeted effect. At same time, integration into care products can make dual functions smell epidermal system nourish repair maximize oil. review delves systems, advocating broader natural resources technology. By strategically utilizing we promote sustainable development global economy. However, extensive clinical trials still required evaluate effectiveness systems.

Language: Английский

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Impact of endocrine disruptors in cosmetics on reproductive function in males and females

Journal of Environmental Science and Health Part C, Journal Year: 2025, Volume and Issue: 43(2), P. 184 - 207

Published: April 3, 2025

The cosmetic and personal care product (PCP) industries have bloomed in the last ten years. Many new brand names established themselves with various lucrative advertisements, luring youths into their primary customers. chemicals infused daily day-night creams or shampoo conditioners been as Endocrine Disrupting Chemicals (EDC). unseen side of coin has flipped this article an attempt to relate rising infertility issue these products. study aims explore potential adverse effects risk assessment EDCs cosmetics products, which highlights a thorough review indicate whether such parabens, phthalates, UV filters are safe for reproductive physiology. may cause severe negative impacts on systems both males females include problems polycystic ovarian syndrome, hypospadias, cryptorchidism, cancer, endometriosis, poor sperm quality. Despite widespread usage purchase products present world, little research conducted possible health. Consequently, further in-depth needs be performed field better understanding risks caused by EDCs.

Language: Английский

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In vitro exposure of porcine spermatozoa to methylparaben, and propylparaben, alone or in combination adversely affects sperm quality

Journal of Applied Toxicology, Journal Year: 2024, Volume and Issue: 44(10), P. 1540 - 1554

Published: June 11, 2024

Parabens (PBs) are widely used in the cosmetic, pharmaceutical, and food industries as preservatives of products. Because its great use, humans other organisms highly exposed daily. However, little is known about effect PBs on male infertility. Therefore, aim present study was to evaluate methylparaben (MePB) propylparaben (PrPB), alone or combination, physiological characteristics pig vitro sperm different concentrations (0, 200, 500, 700 μM) for viability, motility, acrosome integrity evaluation 700, 1000, 2000 DNA fragmentation index evaluation, after 4 h exposure. The results showed that viability decreased exposure MePB from concentration 500 μM. In PrPB mixture groups, at all except control. decrease greater than groups. Sperm motility experimental groups PBs, concentrations, control group. Acrosome not group; however, group, it a 200 μM All exhibited damage Additionally, quality concentration-dependent. demonstrated combination can have adverse effects parameters. had lower toxicity did both mixture. an additive any parameters evaluated. This could partially explain link between PB

Language: Английский

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Association Between Urinary Parabens and Sperm Quality in Nigerian Men: A Case–Control Study

International Journal of General Medicine, Journal Year: 2024, Volume and Issue: Volume 17, P. 2767 - 2779

Published: June 1, 2024

Background: Parabens, which are chemicals used as preservatives in cosmetic and pharmaceutical products, have been reported to be associated with low sperm quality animal human models. Despite the high exposure of men paraben-containing products Nigeria, there no known studies that investigate association parabens country. Objective: To determine urinary levels metabolites count quality. Design/Setting: A multicenter case–control study among fertile infertile five hospitals southern Nigeria. total 136 diagnosed male infertility (cases) were compared 154 controls normal fertility. Urinary (ethyl-paraben, methylparaben, propylparaben, butylparaben) measured using liquid chromatography mass spectrometry, while semen analysis hormone assays carried out World Health Organization standards radioimmunoassay, respectively. Data analyzed non-parametric statistics linear regression. Results: The results showed both cases controls. However, was statistically significant difference ethyl-paraben, butylparaben between In contrast, propylparaben had a decreasing motility groups, but effect only case infertility. regression unit increase significantly decreased (infertile men). Similarly, morphology unadjusted model for men. Only serum testosterone an insignificant correlation parabens. Conclusion: We conclude features poor – motility, morphology, volume. Measures reduce agents containing Nigeria may prevalence Keywords: infertility, parabens, LCMS, study, spermatozoa

Language: Английский

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Paraben Preservatives Exhibit Inhibition on Human and Rat Steroid 5α-Reductase 1: A Comprehensive 3D-QSAR and Computational Analysis

Journal of Hazardous Materials, Journal Year: 2024, Volume and Issue: 480, P. 135841 - 135841

Published: Sept. 20, 2024

Language: Английский

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Characterization of Chemical Exposome in A Paired Human Preconception Pilot Study

Environmental Science & Technology, Journal Year: 2024, Volume and Issue: 58(46), P. 20352 - 20365

Published: Nov. 7, 2024

Parental preconception exposure to synthetic chemicals may have critical influences on fertility and reproduction. Here, we present a robust LC-MS/MS method covering up 95 diverse xenobiotics in human urine, serum, seminal follicular fluids support exposome-wide assessment reproductive health outcomes. Extraction recoveries of validated analytes ranged from 62% 137% limits quantification 0.01 6.0 ng/mL all biofluids. We applied the cohort Australian couples (

Language: Английский

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