Myclobutanil induces cardiotoxicity in developing zebrafish larvae by initiating oxidative stress and apoptosis: The protective role of curcumin DOI Creative Commons
Chunlan Liu, Fan Yang, Jingyu Wang

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 279, P. 116484 - 116484

Published: May 30, 2024

Myclobutanil (MYC) is a common triazole fungicide widely applied in agriculture. MYC extensively exists the natural environment and can be detected organisms. However, little known about MYC-induced embryonic developmental damage. This study aimed to unravel cardiotoxicity of underlying mechanisms, as well cardioprotective effect curcumin (CUR, an antioxidant polyphenol) using zebrafish model. Here, embryos were exposed at concentrations 0, 0.5, 1 2 mg/L from 4 96 h post fertilization (hpf) cardiac development was assessed. As results, reduced survival hatching rate, body length heart but increased malformation rate spontaneous movement. caused abnormal morphology function myl7:egfp transgenic zebrafish, downregulated genes. promoted oxidative stress through excessive reactive oxygen species (ROS) accumulation suppressed activities enzymes, triggering cardiomyocytic apoptosis via upregulated expression apoptosis-related These adverse toxicities could significantly ameliorated by properties CUR, indicating that CUR rescued inhibiting apoptosis. Overall, our revealed potential mechanisms identified cardioprotection this pathological process.

Language: Английский

Myclobutanil induces neurotoxicity by activating autophagy and apoptosis in zebrafish larvae (Danio rerio) DOI
Jiansheng Zhu, Mingtao Huang,

Peiyun Jiang

et al.

Chemosphere, Journal Year: 2024, Volume and Issue: 357, P. 142027 - 142027

Published: April 13, 2024

Language: Английский

Citations

4
Synergistic risk in the gut and liver: Insights into the toxic mechanisms and molecular interactions of combined exposure to triazophos and fenvalerate in zebrafish DOI

Xuehua An,

Ruike Wang, Chong Cao

et al.

The Science of The Total Environment, Journal Year: 2024, Volume and Issue: 948, P. 174710 - 174710

Published: Oct. 1, 2024

Language: Английский

Citations

4
Transcriptomic analysis of the toxic effects and potential mechanisms of fenvalerate on the liver of Odontobutis potamophila DOI
Guoxing Liu, Tian Ran Zhu,

Zihan Zhou

et al.

Aquaculture Reports, Journal Year: 2025, Volume and Issue: 42, P. 102721 - 102721

Published: March 4, 2025

Language: Английский

Citations

0
Embryonic Zebrafish as a Model for Investigating the Interaction between Environmental Pollutants and Neurodegenerative Disorders DOI Creative Commons
Ji‐Hang Yin, Katharine A. Horzmann

Biomedicines, Journal Year: 2024, Volume and Issue: 12(7), P. 1559 - 1559

Published: July 13, 2024

Environmental pollutants have been linked to neurotoxicity and are proposed contribute neurodegenerative disorders. The zebrafish model provides a high-throughput platform for large-scale chemical screening toxicity assessment is widely accepted as an important animal the investigation of Although recent studies explore roles environmental in disorders models, current knowledge mechanisms environmentally induced relatively complex overlapping. This review primarily discusses utilizing embryonic investigate pollutants-related disease. We also applicable approaches biomarkers unravel underlying mechanism related found be powerful tool that evaluating triggered by relevant concentrations neurotoxic compounds. Additionally, using variable assess allows researchers insights into interaction between and, ultimately, understanding toxicants.

Language: Английский

Citations

3
Myclobutanil induces cardiotoxicity in developing zebrafish larvae by initiating oxidative stress and apoptosis: The protective role of curcumin DOI Creative Commons
Chunlan Liu, Fan Yang, Jingyu Wang

et al.

Ecotoxicology and Environmental Safety, Journal Year: 2024, Volume and Issue: 279, P. 116484 - 116484

Published: May 30, 2024

Myclobutanil (MYC) is a common triazole fungicide widely applied in agriculture. MYC extensively exists the natural environment and can be detected organisms. However, little known about MYC-induced embryonic developmental damage. This study aimed to unravel cardiotoxicity of underlying mechanisms, as well cardioprotective effect curcumin (CUR, an antioxidant polyphenol) using zebrafish model. Here, embryos were exposed at concentrations 0, 0.5, 1 2 mg/L from 4 96 h post fertilization (hpf) cardiac development was assessed. As results, reduced survival hatching rate, body length heart but increased malformation rate spontaneous movement. caused abnormal morphology function myl7:egfp transgenic zebrafish, downregulated genes. promoted oxidative stress through excessive reactive oxygen species (ROS) accumulation suppressed activities enzymes, triggering cardiomyocytic apoptosis via upregulated expression apoptosis-related These adverse toxicities could significantly ameliorated by properties CUR, indicating that CUR rescued inhibiting apoptosis. Overall, our revealed potential mechanisms identified cardioprotection this pathological process.

Language: Английский

Citations

0